公开(公告)号：US09675567B2

公开(公告)日：2017-06-13

申请号：US15259064

申请日：2016-09-08

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Simon Edwards ,  Ruth Meriel Kimberley ,  Richard Edward Armer ,  Mohammed Nawaz Khan

IPC: C07C237/20 ,  A61K31/165 ,  A61K31/198 ,  A61K45/06 ,  C07D213/40 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/445 ,  A61K31/5375

CPC classification number: A61K31/165 ,  A61K31/198 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/445 ,  A61K31/5375 ,  A61K45/06 ,  C07C237/20 ,  C07D213/40

Abstract: Compounds of formula (I): and pharmacologically acceptable salts and pro-drugs thereof, wherein the variables are as defined in the specification, are potassium ion channel modulators, making them particularly useful in treating and preventing conditions such as pain, lower urinary tract disorders and the like.