Brownian Microbarcodes for Bioassays
    1.
    发明申请
    Brownian Microbarcodes for Bioassays 审中-公开
    用于生物测定的布朗微条码

    公开(公告)号:US20120157350A1

    公开(公告)日:2012-06-21

    申请号:US13330535

    申请日:2011-12-19

    IPC分类号: C40B60/12

    摘要: Presented are encoded microparticles, methods of use in biological assays, and flexible, modular instrument systems for conducting a variety of biological assays using the encoded microparticles. The systems include various instrumentation components which are exchangeable and offer a single flexible platform on which a large number of different types of experiments and assays may be conducted including, for example, microarray analysis, encoded microparticle single and multiplex detection, tissue dissection and isolation, and other genetic analysis techniques.

    摘要翻译: 呈现的是编码微粒,生物测定中使用的方法,以及灵活的模块化仪器系统,用于使用编码的微粒进行各种生物测定。 这些系统包括可交换的各种仪器组件,并提供单个柔性平台,在该平台上可以进行大量不同类型的实验和测定,包括例如微阵列分析,编码的微粒单次和多重检测,组织解剖和分离, 和其他遗传分析技术。

    Brownian Microbarcodes for Bioassays
    2.
    发明申请
    Brownian Microbarcodes for Bioassays 审中-公开
    用于生物测定的布朗微条码

    公开(公告)号:US20120231453A1

    公开(公告)日:2012-09-13

    申请号:US13336699

    申请日:2011-12-23

    IPC分类号: C12Q1/68

    摘要: An encoded microparticle carrying a spatial code is provided; and a set of encoded microparticles are provided with distinguishable spatial codes, wherein the codes comply with a pre-determined coding scheme. Presented are also methods of using the encoded microparticles in various biological assays, such as various multiplex quantitative PCR (real-time PCR) and multiplex chromosomal immunoprecipitation (ChIP) assays.

    摘要翻译: 提供携带空间码的编码微粒; 并且一组编码的微粒被提供有可区分的空间代码,其中代码符合预定的编码方案。 还提出了在各种生物测定中使用编码的微粒的方法,例如各种多重定量PCR(实时PCR)和多重染色体免疫沉淀(ChIP)测定。

    MINIATURIZED MICROPARTICLES
    3.
    发明申请
    MINIATURIZED MICROPARTICLES 有权
    微型化微生物

    公开(公告)号:US20100297448A1

    公开(公告)日:2010-11-25

    申请号:US12779413

    申请日:2010-05-13

    IPC分类号: B32B9/00

    摘要: A system and method for encoded microparticles is described. One embodiment includes an encoded microparticle comprising a plurality of segments, wherein the plurality of segments form a spatial code; contrast coating on at least one segment of the plurality of segments, wherein the contrast coating further encodes the microparticle; an outer surface, wherein the outer surface encloses the spatial code and contrast coating, and wherein the spatial code and contrast coating are detectable through the outer surface.

    摘要翻译: 描述了编码微粒的系统和方法。 一个实施例包括包含多个段的编码微粒,其中多个段形成空间代码; 在多个片段的至少一个片段上形成对比涂层,其中所述造影剂进一步编码所述微粒; 外表面,其中所述外表面包围所述空间代码和对比涂层,并且其中所述空间代码和对比涂层可通过所述外表面检测。

    Miniaturized Microparticles
    6.
    发明申请
    Miniaturized Microparticles 有权
    微型微粒

    公开(公告)号:US20120196381A1

    公开(公告)日:2012-08-02

    申请号:US13337024

    申请日:2011-12-23

    IPC分类号: G01N33/53 G01N21/64 G03F7/20

    摘要: An encoded microparticle having a spatial code is provided; and a set of encoded microparticles possessing subsets each provided with a distinguishable spatial code, wherein the codes comply with a pre-determined coding scheme. Presented are also methods of using the encoded microparticles in various biological assays, such as various multiplex assays and visualizing them by creating a digital image of the encoded microparticles and determining whether false positives are present. Further are provided methods of manufacture of the encoded microparticles which employ ferromagnetic nanoparticles applied using spin-on-glass techniques.

    摘要翻译: 提供具有空间码的编码微粒; 以及一组编码的微粒,其具有各自具有可区分的空间码的子集,其中所述码符合预定编码方案。 还提出了在各种生物测定中使用编码的微粒的方法,例如各种多重测定,并通过产生编码的微粒的数字图像并确定是否存在假阳性来使其可视化。 还提供了使用旋涂玻璃技术应用铁磁性纳米粒子的编码微粒的制造方法。

    Miniaturized microparticles
    7.
    发明授权
    Miniaturized microparticles 有权
    微型微粒

    公开(公告)号:US08697334B2

    公开(公告)日:2014-04-15

    申请号:US13337024

    申请日:2011-12-23

    摘要: An encoded microparticle having a spatial code is provided; and a set of encoded microparticles possessing subsets each provided with a distinguishable spatial code, wherein the codes comply with a pre-determined coding scheme. Presented are also methods of using the encoded microparticles in various biological assays, such as various multiplex assays and visualizing them by creating a digital image of the encoded microparticles and determining whether false positives are present. Further are provided methods of manufacture of the encoded microparticles which employ ferromagnetic nanoparticles applied using spin-on-glass techniques.

    摘要翻译: 提供具有空间码的编码微粒; 以及一组编码的微粒,其具有各自具有可区分的空间码的子集,其中所述码符合预定编码方案。 还提出了在各种生物测定中使用编码的微粒的方法,例如各种多重测定,并通过产生编码的微粒的数字图像并确定是否存在假阳性来使其可视化。 还提供了使用旋涂玻璃技术应用铁磁性纳米粒子的编码微粒的制造方法。

    Multiple step printing methods for microbarcodes
    8.
    发明授权
    Multiple step printing methods for microbarcodes 有权
    用于微条码的多步打印方法

    公开(公告)号:US08460854B2

    公开(公告)日:2013-06-11

    申请号:US13340254

    申请日:2011-12-29

    申请人: Randall J. True

    发明人: Randall J. True

    IPC分类号: G03F7/00 G03F7/20

    摘要: A system and method for forming encoded microparticles is described. One embodiment includes a method for forming a microparticle, the method comprising providing a pattern, wherein the pattern defines a code element, printing the pattern on a substrate to form a first code element within a microparticle region, printing the pattern on the substrate to form at least one successive code element, such that the first code element and the at least one successive code element are within the same microparticle region, wherein a code is formed by the first code element and any successive code elements.

    摘要翻译: 描述了用于形成编码的微粒的系统和方法。 一个实施例包括形成微粒的方法,所述方法包括提供图案,其中所述图案限定代码元素,将图案印刷在基底上以在微粒区域内形成第一代码元素,将图案印刷在基底上以形成 至少一个连续的代码元素,使得第一代码元素和至少一个连续代码元素在相同的微粒区域内,其中代码由第一代码元素和任何连续代码元素形成。

    Miniaturized microparticles
    9.
    发明授权
    Miniaturized microparticles 有权
    微型微粒

    公开(公告)号:US08178278B2

    公开(公告)日:2012-05-15

    申请号:US12779413

    申请日:2010-05-13

    IPC分类号: G03F7/00 G03F7/004 G03F7/20

    摘要: A system and method for encoded microparticles is described. One embodiment includes an encoded microparticle comprising a plurality of segments, wherein the plurality of segments form a spatial code; contrast coating on at least one segment of the plurality of segments, wherein the contrast coating further encodes the microparticle; an outer surface, wherein the outer surface encloses the spatial code and contrast coating, and wherein the spatial code and contrast coating are detectable through the outer surface.

    摘要翻译: 描述了编码微粒的系统和方法。 一个实施例包括包含多个段的编码微粒,其中多个段形成空间代码; 在多个片段的至少一个片段上形成对比涂层,其中所述造影剂进一步编码所述微粒; 外表面,其中所述外表面包围所述空间代码和对比涂层,并且其中所述空间代码和对比涂层可通过所述外表面检测。