公开(公告)号：US09181634B2

公开(公告)日：2015-11-10

申请号：US10583920

申请日：2004-12-21

Applicant: Michael J. Sailor ,  Shawn O. Meade

Inventor： Michael J. Sailor ,  Shawn O. Meade

IPC: C40B20/04 ,  C40B20/08 ,  B01J19/00 ,  B82Y20/00 ,  C40B30/04 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B40/18 ,  C40B50/14 ,  C40B70/00

CPC classification number: C40B20/08 ,  B01J19/0046 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/0054 ,  B01J2219/00547 ,  B01J2219/00554 ,  B01J2219/0056 ,  B01J2219/00565 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B82Y20/00 ,  C40B20/04 ,  C40B30/04 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B40/18 ,  C40B50/14 ,  C40B70/00

Abstract: The invention concerns a particle having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum. An assay detection method uses such a particle and detects a spectral shift in the presence of an analyte. Additional embodiments are disclosed including additional features.

Abstract translation: 本发明涉及一种具有通过嵌入其物理结构中的代码库的代码的粒子，其粒子的不同区域之间的折射率变化。 在优选实施例中，薄膜具有以产生在反射率谱中可检测的代码的方式变化的孔隙率。 测定检测方法使用这样的颗粒并在存在分析物的情况下检测光谱偏移。 公开了另外的实施例，其包括附加特征。

公开(公告)号：US20130090260A1

公开(公告)日：2013-04-11

申请号：US13708778

申请日：2012-12-07

Applicant: Michael P. Nova ,  Andrew E. Senyei

Inventor： Michael P. Nova ,  Andrew E. Senyei

IPC: C40B30/04 ,  C40B60/08

CPC classification number: C40B30/04 ,  B01J19/0046 ,  B01J2219/00295 ,  B01J2219/00299 ,  B01J2219/00308 ,  B01J2219/00333 ,  B01J2219/00344 ,  B01J2219/00461 ,  B01J2219/00463 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/0054 ,  B01J2219/00542 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00551 ,  B01J2219/0056 ,  B01J2219/00563 ,  B01J2219/00567 ,  B01J2219/00569 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0609 ,  B82Y10/00 ,  C07K1/00 ,  C07K1/04 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00732 ,  G01N35/00871 ,  G01N2015/149 ,  G01N2035/00782 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/025

Abstract: In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix particle with a substrate adapted for attachment and/or synthesis of molecules. A spectrally-encoded identifier embodied in a photochemical medium is embedded or encased within the substrate to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions, and then placed within the path of an optical detector adapted to read the spectrally-encoded identifier and measure biochemical activity on each support matrix particle. The measured biochemical activity is associated with the unique identity of the support matrix particle and, hence, with the molecule attached to the particle.

Abstract translation: 在多重测定中，多个分子的每个分子连接到具有适于附着和/或合成分子的底物的载体基质颗粒上。 在光化学介质中实施的经光谱编码的标识符被嵌入或封装在衬底内以唯一地识别附着于衬底的分子。 分子暴露于一个或多个处理条件，然后放置在适于读取频谱编码的标识符的光学检测器的路径内，并测量每个支持矩阵粒子上的生化活性。 测量的生物化学活性与支持基质颗粒的独特特性相关联，因此与附着于颗粒的分子相关。

公开(公告)号：US07935659B2

公开(公告)日：2011-05-03

申请号：US11011452

申请日：2004-12-14

Applicant: Michael P. Nova ,  Andrew E. Senyei ,  Zahra Parandoosh ,  Gary S. David ,  Xiao-Yi Xiao

Inventor： Michael P. Nova ,  Andrew E. Senyei ,  Zahra Parandoosh ,  Gary S. David ,  Xiao-Yi Xiao

IPC: C40B50/16 ,  C40B50/18

CPC classification number: C40B30/04 ,  B01J19/0046 ,  B01J2219/00295 ,  B01J2219/00299 ,  B01J2219/00308 ,  B01J2219/00333 ,  B01J2219/00344 ,  B01J2219/00461 ,  B01J2219/00463 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/0054 ,  B01J2219/00542 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00551 ,  B01J2219/0056 ,  B01J2219/00563 ,  B01J2219/00567 ,  B01J2219/00569 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2300/0609 ,  B82Y10/00 ,  C07K1/00 ,  C07K1/04 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00732 ,  G01N35/00871 ,  G01N2015/149 ,  G01N2035/00782 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/025

Abstract: Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.

Abstract translation: 提供了具有包含至少一个数据存储单元的具有可远程寻址或远程可编程记录设备的矩阵材料的具有存储器的组合。 基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。 基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。 数据存储单元是非易失性反熔丝存储器或易失性存储器，例如EEPROMS，DRAMS或闪存。 通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的 信息。 还提供了基质材料，记忆和连接分子和生物材料的组合。 这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。 还提供了用于电子标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲近测定，非放射性邻近测定和其它方法。

公开(公告)号：US20100248981A1

公开(公告)日：2010-09-30

申请号：US12749330

申请日：2010-03-29

Applicant: Mohsen Shirazi

Inventor： Mohsen Shirazi

IPC: C40B60/04 ,  C40B60/00 ,  C40B30/00 ,  C40B30/04

CPC classification number: B01L9/523 ,  B01J2219/00317 ,  B01J2219/00529 ,  B01J2219/00545 ,  B01J2219/00554 ,  B01J2219/0056 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01L2200/025 ,  B01L2300/0829 ,  G01N35/0099 ,  G01N2035/00158

Abstract: A device, method and system for ensuring proper orientation and installation of trays for processing biological sensors in an automated and flexible system are provided. The system comprises an instrument handling robot that transfers a plurality of arrays mounted on pegs on a strip to liquid reaction stations. In particular, the method comprises a first orientation marking on a tray and a second orientation marking on a deck, indicating the proper station in which the tray is placed for a specific process.

Abstract translation: 提供了一种用于确保在自动化和灵活的系统中处理生物传感器的托盘的适当取向和安装的装置，方法和系统。 该系统包括将安装在带上的钉上的多个阵列传送到液体反应站的仪器处理机器人。 特别地，该方法包括托盘上的第一取向标记和甲板上的第二取向标记，指示托盘放置在特定工艺中的适当工位。

公开(公告)号：US20050158738A1

公开(公告)日：2005-07-21

申请号：US10958348

申请日：2004-10-06

Applicant: Nobuyuki Okamura ,  Tadashi Okamoto ,  Makoto Kameyama

Inventor： Nobuyuki Okamura ,  Tadashi Okamoto ,  Makoto Kameyama

IPC: B01J19/00 ,  B01L3/00 ,  B05D3/00 ,  C12M1/34 ,  C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00432 ,  B01J2219/00497 ,  B01J2219/0056 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00731 ,  B01L3/5085 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14

Abstract: A carrier having indexes in a probe non-fixing region is used and solutions containing probes are applied to respective specific positions on the carrier by referring to said indexes and fixed. The position of a target compound that is specifically bonded to a probe fixed to a probe carrier manufactured by a method according to the invention can be accurately and quickly detected by referring to the indexes.

Abstract translation: 使用具有探针非固定区域中的索引的载体，并且将包含探针的溶液通过参考所述索引应用于载体上的各个特定位置并固定。 通过参照这些指标，可以准确，快速地检测特异性地结合固定于通过本发明的方法制造的探针载体的探针的探针的目标化合物的位置。

公开(公告)号：US5751629A

公开(公告)日：1998-05-12

申请号：US484504

申请日：1995-06-07

Applicant: Michael P. Nova ,  Andrew E. Senyei

Inventor： Michael P. Nova ,  Andrew E. Senyei

IPC: B01J19/00 ,  B01L3/00 ,  C07K1/00 ,  C07K1/04 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00 ,  G01N15/14 ,  G01N35/00 ,  G11C13/02

CPC classification number: G01N35/00871 ,  B01J19/0046 ,  B82Y10/00 ,  C07K1/00 ,  C07K1/04 ,  C07K1/047 ,  G01N35/00732 ,  G11C13/0014 ,  G11C13/0019 ,  B01J2219/00295 ,  B01J2219/00299 ,  B01J2219/00308 ,  B01J2219/00344 ,  B01J2219/00461 ,  B01J2219/00463 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/0054 ,  B01J2219/00542 ,  B01J2219/00549 ,  B01J2219/00551 ,  B01J2219/0056 ,  B01J2219/00567 ,  B01J2219/00569 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00 ,  G01N2015/149 ,  G01N2035/00782 ,  G11C13/025

Abstract: Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The data storage units are preferably non-volatile antifuse memories. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, chemical modification and other uses. Methods for electroniclly tagging molecules are biological particles and matrix support materials and immunoassays and and other methods are also provided.

Abstract translation: 提供了具有包含至少一个数据存储单元的具有可远程寻址或远程可编程记录设备的矩阵材料的具有存储器的组合。 基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。 数据存储单元优选地是非易失性反熔丝存储器。 通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的 信息。 还提供了基质材料，记忆和连接分子和生物材料的组合。 这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，化学修饰和其它用途。 电子标签分子的方法是生物颗粒和基质支持材料和免疫测定法，还提供了其它方法。

公开(公告)号：US10076755B2

公开(公告)日：2018-09-18

申请号：US13318827

申请日：2010-05-04

Applicant: Johannes Landgraf ,  Günther Proll ,  Florian Pröll

Inventor： Johannes Landgraf ,  Günther Proll ,  Florian Pröll

IPC: B01L3/00 ,  B01J19/00

CPC classification number: B01L3/54 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00527 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00551 ,  B01J2219/0056 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01L2200/12 ,  B01L2300/021 ,  B01L2300/0636

Abstract: The invention relates to a recognizable carrier for determining physical, chemical or biochemical interactions by means of optical measurement methods. The carrier comprises a surface that defines a substrate surface and that has a base layer coated with reactive elements, which are bonded to receptor molecules, wherein the base layer and/or the reactive elements are provided with a pattern of holes which forms a code and/or the reactive elements are provided with linker molecules or markers which form a code. The substrate surface may additionally have a macroscopically planar pattern which is applied using laser light or chemical etching and forms a code. The invention likewise relates to a method for producing a recognizable carrier for spectroscopic processes and/or intensiometric tests to determine said interactions. The code to recognize the carrier can be controlled via a read-out unit coupled to the photometric analysis unit. Such a carrier can be used to analyze biomolecules during security checks, access controls or in-vitro diagnostics.

公开(公告)号：US08333932B2

公开(公告)日：2012-12-18

申请号：US12704163

申请日：2010-02-11

Applicant: Kyu-sang Lee ,  Seong-ho Cho ,  Carl S. Brown ,  Kyla Teplitz

Inventor： Kyu-sang Lee ,  Seong-ho Cho ,  Carl S. Brown ,  Kyla Teplitz

IPC: G01N33/48

CPC classification number: B01J19/0046 ,  B01J2219/0054 ,  B01J2219/0056 ,  B01J2219/00608 ,  B01J2219/00693 ,  Y10T428/24802

Abstract: A substrate includes; a fiducial mark disposed on the substrate, an area on the substrate on which a probe material is configured to be immobilized, the area being separated from the fiducial mark, and a probe immobilization compound disposed on the area on the substrate on which the probe material is configured to be immobilized, wherein the fiducial mark has a structure which reflects irradiated light at a greater intensity than an intensity of reflected irradiated light form the area on the substrate not corresponding to the fiducial mark.

Abstract translation: 基板包括： 设置在基板上的基准标记，基板上的被配置为固定的探针材料的区域，与基准标记分离的区域，以及设置在基板上的探针固定化合物上的探针固定化合物，探针材料 被配置为被固定，其中基准标记具有以比反射的照射光的强度更大的强度反射照射的光的结构，形成不对应于基准标记的基板上的区域。

公开(公告)号：US20120052597A1

公开(公告)日：2012-03-01

申请号：US13318827

申请日：2010-05-04

Applicant: Johannes Landgraf ,  Günther Proll ,  Florian Pröll

Inventor： Johannes Landgraf ,  Günther Proll ,  Florian Pröll

IPC: G01N33/543 ,  C23F1/02 ,  B05D3/06 ,  B01L3/00 ,  B05D5/00

CPC classification number: B01L3/54 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00527 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00551 ,  B01J2219/0056 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01L2200/12 ,  B01L2300/021 ,  B01L2300/0636

Abstract: The invention relates to a recognizable carrier for determining physical, chemical or biochemical interactions by means of optical measurement methods. The carrier comprises a surface that defines a substrate surface and that has a base layer coated with reactive elements, which are bonded to receptor molecules, wherein the base layer and/or the reactive elements are provided with a pattern of holes which forms a code and/or the reactive elements are provided with linker molecules or markers which form a code. The substrate surface may additionally have a macroscopically planar pattern which is applied using laser light or chemical etching and forms a code. The invention likewise relates to a method for producing a recognizable carrier for spectroscopic processes and/or intensiometric tests to determine said interactions. The code to recognize the carrier can be controlled via a read-out unit coupled to the photometric analysis unit. Such a carrier can be used to analyze biomolecules during security checks, access controls or in-vitro diagnostics.

Abstract translation: 本发明涉及通过光学测量方法确定物理，化学或生化相互作用的可识别载体。 载体包括限定基底表面并且具有涂覆有反应性元件的基底层的表面，其与受体分子结合，其中基底层和/或反应性元件设置有形成代码的孔的图案， /或反应性元件提供有形成代码的连接分子或标记。 衬底表面可以另外具有使用激光或化学蚀刻施加的宏观平面图案并形成代码。 本发明同样涉及用于制造用于光谱过程和/或强度测试的可识别载体的方法，以确定所述相互作用。 可以通过耦合到测光分析单元的读出单元来控制用于识别载体的代码。 这种载体可用于在安全检查，进入控制或体外诊断过程中分析生物分子。

公开(公告)号：US20100173803A1

公开(公告)日：2010-07-08

申请号：US12377174

申请日：2007-08-10

Applicant: Anke Pierik ,  Johan Frederik Dijksman ,  Martin Maurice Vernhout ,  Leonardus Johannes Cornelius Van Den Besselaar ,  Dirkjan Bernhard Van Dam ,  Giovanni Nisato ,  Albert Hendrik Jan Immink

Inventor： Anke Pierik ,  Johan Frederik Dijksman ,  Martin Maurice Vernhout ,  Leonardus Johannes Cornelius Van Den Besselaar ,  Dirkjan Bernhard Van Dam ,  Giovanni Nisato ,  Albert Hendrik Jan Immink

IPC: C40B50/14 ,  C40B60/14 ,  G06F17/00

CPC classification number: B41J29/393 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00542 ,  B01J2219/00547 ,  B01J2219/0056 ,  B01J2219/00567 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/00677 ,  B01J2219/00693 ,  B01J2219/00695 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00743 ,  B01L3/0268 ,  B01L3/545 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/022 ,  B82Y30/00 ,  G01N35/00732

Abstract: The invention provides an ink jet device and method for producing a biological assay substrate (41) by releasing a plurality of substances onto the substrate (41) The device comprises at least a print head and a plurality of substance containers (60, 61, 62) connectable thereto, and mounting means (55) for the containers, whereby at least part of the containers (60, 61, 62) is provided with identification means (63) The device further comprises reading means to read information contained in the identification means (63).

Abstract translation: 本发明提供一种通过将多种物质释放到基底（41）上来生产生物测定基底（41）的喷墨装置和方法。该装置包括至少一个打印头和多个物质容器（60,61,62 ）和用于容器的安装装置（55），由此至少一部分容器（60,61,62）设置有识别装置（63）。该装置还包括读取装置，用于读取包含在识别装置 （63）。