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1.发明授权Process for the synthesis of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo[3,]pyrimidin-4-ones 失效2-氨基-3,5-二氢-7-取代-4H-吡咯并[3,2-d]嘧啶-4-酮的合成方法
公开(公告)号：US5386031A
公开(公告)日：1995-01-31
申请号：US167751
申请日：1993-12-15
IPC分类号： A61K31/505 , A61P19/06 , A61P37/00 , C07D487/04 , C07B31/00
CPC分类号： C07D487/04
摘要： An improved process for the preparation of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo[3,2-d]pyrimidin-4-ones is described wherein 2,6-diamino-3,5-dihydro-7-substituted-4H-pyrrolo[3,2-d]pyrimidin-4-one is converted to a diazonium salt which is subsequently catalytically hydrogenated to the desired compound, as well as valuable intermediates used in the process.
摘要翻译： 描述了制备2-氨基-3,5-二氢-7-取代-4H-吡咯并[3,2-d]嘧啶-4-酮的改进方法，其中2,6-二氨基-3,5-二氢 -7-取代-4H-吡咯并[3,2-d]嘧啶-4-酮转化成重氮盐，其随后催化氢化成所需化合物，以及在该方法中使用的有价值的中间体。
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公开(公告)号：US5362883A
公开(公告)日：1994-11-08
申请号：US208771
申请日：1994-03-08
IPC分类号： C07C227/10 , C07C227/12 , C07C227/22 , C07C229/28 , C07C255/46 , C07D209/54
CPC分类号： C07C227/12 , C07C227/10 , C07C227/22 , C07C229/28 , C07C255/46 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要： An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.
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公开(公告)号：US5319135A
公开(公告)日：1994-06-07
申请号：US072212
申请日：1993-06-04
IPC分类号： C07C227/10 , C07C227/12 , C07C227/22 , C07C229/28 , C07C255/46 , C07D209/96
CPC分类号： C07C227/12 , C07C227/10 , C07C227/22 , C07C229/28 , C07C255/46 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要： An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.
摘要翻译： 描述了通过新的合成制备环状氨基酸的改进方法，其中二腈衍生物在两个步骤中转化为所需产物，以及在该方法中使用的有价值的中间体。
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公开(公告)号：US5132451A
公开(公告)日：1992-07-21
申请号：US564623
申请日：1990-08-10
IPC分类号： C07C227/10 , C07C227/12 , C07C227/22 , C07C229/28 , C07C255/46
CPC分类号： C07C227/22 , C07C227/10 , C07C227/12 , C07C229/28 , C07C255/46 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要： An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.
摘要翻译： 描述了通过新的合成制备环状氨基酸的改进方法，其中二腈衍生物在两个步骤中转化为所需产物，以及在该方法中使用的有价值的中间体。
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5.发明授权Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole -2-carboxylic acids, preparation of, and medical compositions thereof 失效1- [2 - [（1-烷氧基羰基-3-芳烷基） - 氨基] -1-氧代烷基]八氢-1H-吲哚-2-羧酸的磷酸盐，及其医药组合物
公开(公告)号：US4490386A
公开(公告)日：1984-12-25
申请号：US422499
申请日：1982-09-23
IPC分类号： C07D209/42 , A61K31/405 , C07D209/18
CPC分类号： C07D209/42
摘要： Phosphate salts of the substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acid are produced by treating a suitably substituted octahydro-1H-indole with phosphoric acid. The phosphate salts of the compounds and pharmaceutical compositions thereof are useful as antihypertensive agents.
摘要翻译： 通过用磷酸处理适当取代的八氢-1H-吲哚来制备八氢-1H-吲哚-2-羧酸的取代的酰基衍生物的磷酸盐。 化合物的磷酸盐及其药物组合物可用作抗高血压药。
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