公开(公告)号：US09616138B1

公开(公告)日：2017-04-11

申请号：US14498988

申请日：2014-09-26

Applicant: Raul Iglesias ,  Piyush Koria

Inventor： Raul Iglesias ,  Piyush Koria

IPC: A61K38/00 ,  A61K47/48 ,  C07K14/475 ,  A61K38/18 ,  A61K38/10 ,  C07K14/485 ,  C07K14/78

CPC classification number: A61K47/48292 ,  A61K38/10 ,  A61K38/1825 ,  C07K14/475 ,  C07K14/485 ,  C07K14/78 ,  C07K2319/10 ,  C07K2319/33 ,  C07K2319/735

Abstract: Disclosed herein are cargo carrying nanoparticles and pharmaceutical formulations thereof. The cargo carrying nanoparticles can self-assemble from cargo molecule subunits and/or targeting subunits. The cargo carrying molecules can be configured to induce macropinocytosis in a cell when a targeting moiety specifically binds a binding partner on the surface of a cell. The pharmaceutical formulations containing the cargo carrying nanoparticles disclosed herein can be administered to a patient for the treatment or prevention of cancer.