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公开(公告)号：US09616138B1
公开(公告)日：2017-04-11
申请号：US14498988
申请日：2014-09-26
Applicant: Raul Iglesias , Piyush Koria
Inventor： Raul Iglesias , Piyush Koria
IPC: A61K38/00 , A61K47/48 , C07K14/475 , A61K38/18 , A61K38/10 , C07K14/485 , C07K14/78
CPC classification number: A61K47/48292 , A61K38/10 , A61K38/1825 , C07K14/475 , C07K14/485 , C07K14/78 , C07K2319/10 , C07K2319/33 , C07K2319/735
Abstract: Disclosed herein are cargo carrying nanoparticles and pharmaceutical formulations thereof. The cargo carrying nanoparticles can self-assemble from cargo molecule subunits and/or targeting subunits. The cargo carrying molecules can be configured to induce macropinocytosis in a cell when a targeting moiety specifically binds a binding partner on the surface of a cell. The pharmaceutical formulations containing the cargo carrying nanoparticles disclosed herein can be administered to a patient for the treatment or prevention of cancer.
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2.发明申请ELASTIN BASED GROWTH FACTOR DELIVERY PLATFORM FOR WOUND HEALING AND REGENERATION 有权基于ELASTIN的生长因子递送平台，用于伤口愈合和再生公开(公告)号：US20110092422A1
公开(公告)日：2011-04-21
申请号：US12899141
申请日：2010-10-06
Applicant: Piyush Koria , Martin L. Yarmush , Yaakov Nahmias
Inventor： Piyush Koria , Martin L. Yarmush , Yaakov Nahmias
CPC classification number: C07K14/475 , A61K38/00 , C07K14/78 , C07K2319/70
Abstract: The invention is based on the discovery of a potent growth factor delivery system by creating a fusion polypeptide that includes two portions: (i) keratinocyte growth factor protein, and (ii) an elastin-like peptide. This chimera can be administered directly to a wound site, accelerating recovery.
Abstract translation: 本发明基于通过产生包含两部分的融合多肽来发现有效的生长因子递送系统：（i）角化细胞生长因子蛋白，和（ii）弹性蛋白样肽。 该嵌合体可以直接施用于伤口部位，加速恢复。
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公开(公告)号：US20170100506A1
公开(公告)日：2017-04-13
申请号：US15290742
申请日：2016-10-11
Applicant: Yuan Yuan , Piyush Koria
Inventor： Yuan Yuan , Piyush Koria
IPC: A61L26/00
CPC classification number: A61L26/0047 , A61L26/0066 , A61L2300/252 , A61L2300/412 , A61L2300/45 , A61L2400/12
Abstract: A formulation and method of treating chronic wounds is presented. The formulation uses two different fusion peptides, one of which incorporates an elastase resistant peptide, to preserve the bioactivity of different functional peptides and growth factors in chronic wounds.
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4.发明授权Elastin based growth factor delivery platform for wound healing and regeneration 有权用于伤口愈合和再生的基于弹性蛋白的生长因子递送平台公开(公告)号：US08940868B2
公开(公告)日：2015-01-27
申请号：US12899141
申请日：2010-10-06
Applicant: Piyush Koria , Martin L. Yarmush , Yaakov Nahmias
Inventor： Piyush Koria , Martin L. Yarmush , Yaakov Nahmias
IPC: C07K19/00 , A61K38/16 , C07K14/475 , C07K14/78 , A61K38/00
CPC classification number: C07K14/475 , A61K38/00 , C07K14/78 , C07K2319/70
Abstract: The invention is based on the discovery of a potent growth factor delivery system by creating a fusion polypeptide that includes two portions: (i) keratinocyte growth factor protein, and (ii) an elastin-like peptide. This chimera can be administered directly to a wound site, accelerating recovery.
Abstract translation: 本发明基于通过产生包含两部分的融合多肽来发现有效的生长因子递送系统：（i）角化细胞生长因子蛋白，和（ii）弹性蛋白样肽。 该嵌合体可以直接施用于伤口部位，加速恢复。
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