公开(公告)号：US20180327461A1

公开(公告)日：2018-11-15

申请号：US15574679

申请日：2016-05-18

Applicant: Ravi DURVASULA ,  ARORA Arinder Humar ,  STC.UNM

Inventor： Ravi Durvasula ,  Arinder Kumar Arora

IPC: C07K14/435 ,  C07K14/47 ,  A01N63/00 ,  C07K16/12

CPC classification number: C07K14/43572 ,  A01N63/00 ,  C07K14/4723 ,  C07K16/1203 ,  C07K16/1228 ,  C07K2319/30

Abstract: This disclosure describes a genetically-modified microbe that is a symbiont of an animal that is a vector organism for a pathogenic microbe, a paratransgenic organism that includes the genetically-modified microbe, and methods involving use of the genetically-modified microbe and/or the paratransgenic organism. Generally, the genetically-modified microbe includes a heterologous polynucleotide that encodes a heterologous polypeptide that reduces transmission of the pathogenic microbe.