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    Antibiotic composition
    4.
    发明授权
    Antibiotic composition 失效
    抗生素组成

    公开(公告)号：US4226879A

    公开(公告)日：1980-10-07

    申请号：US939102

    申请日：1978-09-01

    申请人： Satoshi Omura ,  Chiaki Kitao ,  Akira Nakagawa ,  Haruo Tanaka ,  Juichi Awaya ,  Ruiko Oiwa

    发明人： Satoshi Omura ,  Chiaki Kitao ,  Akira Nakagawa ,  Haruo Tanaka ,  Juichi Awaya ,  Ruiko Oiwa

    IPC分类号： A23K20/195 ,  A61K31/335 ,  A61K35/00 ,  C07D303/06

    CPC分类号： A23K20/195

    摘要： The present invention relates to a new composition designated as AM-1042 or asukamycin. AM-1042 has an antibiotic activity upon Gram-positive bacteria and Eimeria, and its acute toxicity (LD.sub.50 ' ip.) in mice was 48.5 mg./kg. AM-1042 has an excellent therapeutical effect on various infectious diseases caused by a parasite of Gram-positive bacteria and Eimeria. AM-1042 has been confirmed to be distinguishable from known antibiotics such as e.g. amicetin B, azomycin and manumycin. AM-1042 is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing AM-1042. A composition capable of preventing and curing coccidiosis of poultry containing AM-1042 as active ingredient.

    摘要翻译： 本发明涉及一种称为AM-1042或无菌素的新组合物。 AM-1042对革兰氏阳性菌和艾美球虫具有抗菌活性，其在小鼠中的急性毒性（LD50'ip。）为48.5mg./kg。 AM-1042对由革兰氏阳性菌和艾美球虫寄生虫引起的各种感染性疾病具有极好的治疗作用。 已证实AM-1042可与已知的抗生素区别，例如： amicetin B，azomycin和manumycin。 AM-1042是通过发酵属于链霉菌属的微生物并产生AM-1042产生的。 一种能够预防和治疗含有AM-1042作为活性成分的家禽的球虫病的组合物。

    Trichostatin as an antiprotozoal agent
    6.
    发明授权
    Trichostatin as an antiprotozoal agent 失效
    曲古抑菌素作为抗原虫药

    公开(公告)号：US4218478A

    公开(公告)日：1980-08-19

    申请号：US1246

    申请日：1979-01-05

    申请人： Satoshi Omura ,  Ruiko Oiwa

    发明人： Satoshi Omura ,  Ruiko Oiwa

    IPC分类号： A61K31/165 ,  A61K31/16

    CPC分类号： A61K31/165

    摘要： Trichostatin (I) is disclosed to be useful as an antiprotozoal agent for the treatment of diseases in man and animals. Also disclosed are pharmaceutical compositions comprising trichostatin for treating protozoal infections. Trichostatin has the structure: ##STR1##

    摘要翻译： 公开了曲古抑菌素（I）可用作治疗人和动物疾病的抗原虫药。 还公开了包含用于治疗原生动物感染的曲古抑菌素的药物组合物。 曲古抑菌素具有以下结构： I

    Antibiotic OS-3256-B
    7.
    发明授权
    Antibiotic OS-3256-B 失效
    抗生素OS-3256-B

    公开(公告)号：US3995028A

    公开(公告)日：1976-11-30

    申请号：US606687

    申请日：1975-08-21

    申请人： Satoshi Omura ,  Iwao Umezawa ,  Keiki Satoh ,  Juichi Awaya ,  Kanki Komiyama ,  Ruiko Oiwa

    发明人： Satoshi Omura ,  Iwao Umezawa ,  Keiki Satoh ,  Juichi Awaya ,  Kanki Komiyama ,  Ruiko Oiwa

    IPC分类号： C07G11/00 ,  A61K35/74

    CPC分类号： A61K36/06 ,  C07G11/00 ,  Y10S435/892

    摘要： The present invention relates to a new antibiotic designated as OS-3256-B. OS-3256-B exhibits excellent inhibitory activities against animal tumors such as leukemia L-1210, Sarcoma-180 and Hela cells and gram-positive bacteria and is classified into the diazocompounds group. However, chromatographic analysis, Rf value and other experimental data reveal that OS-3256-B is a new compound of the type of azaamino acid derivatives. The present invention also provides a process for producing OS-3256-B by fermentation, in which OS-3256-B is produced by culturing a microorganism belonging to Streptomyces candidus var. azaticus in a culture medium conventionally used for culturing Streptomyces strain microorganisms.

    摘要翻译： 本发明涉及一种称为OS-3256-B的新型抗生素。 OS-3256-B对动物肿瘤例如白血病L-1210，肉瘤180和Hela细胞和革兰氏阳性细菌具有优异的抑制活性，并被分类为重氮化合物组。 然而，色谱分析，Rf值等实验数据表明，OS-3256-B是一种新型的氮杂氨基酸衍生物化合物。 本发明还提供了通过发酵生产OS-3256-B的方法，其中OS-3256-B是通过培养属于Streptomyces candidus var。 通常用于培养链霉菌菌株微生物的培养基中的azaticus。