Saquinavir derivatives useful in immunoassay
    1.
    发明授权
    Saquinavir derivatives useful in immunoassay 失效
    沙奎那韦衍生物用于免疫测定

    公开(公告)号:US06992177B1

    公开(公告)日:2006-01-31

    申请号:US11009823

    申请日:2004-12-10

    摘要: Analogs of saquinavir functionalized at the quinoline portion of the molecule are described. These include pyridyl analogs (replacing the quinoline ring) with a functional handle out of the ring allowing for elaboration with linkers terminated by a functional group such as an activated ester which are useful for attaching the molecule to other entities such as proteins, polysaccharides, and the like. Analogs of saquinavir derivatized out of the quinoline ring are also described.

    摘要翻译: 描述了在分子的喹啉部分官能化的沙奎那韦的类似物。 这些包括吡啶基类似物(取代喹啉环)与环之间的功能性手段,允许用由用于将分子连接到其它实体例如蛋白质,多糖的官能团如活化酯封端的连接体进行精制,和 类似。 还描述了衍生自喹啉环的沙奎那韦的类似物。

    Electrofusion cell and method of making the same
    3.
    发明授权
    Electrofusion cell and method of making the same 失效
    电凝细胞及其制法

    公开(公告)号:US4832814A

    公开(公告)日:1989-05-23

    申请号:US138040

    申请日:1987-12-28

    申请人: Richard T. Root

    发明人: Richard T. Root

    IPC分类号: C12M3/00 C12N13/00

    CPC分类号: C12M35/02 C12N13/00

    摘要: An apparatus and method of use is provided for the fusion of different cell types into hybrid cells through the use of electrofusion. The apparatus consists of thin-film electrodes etched onto an optically clear lower plate, a channel defined at its boundaries by a photocopolymer material laminated between the lower plate and an upper optically clear top plate providing closure of the channel as well as entry for the cells through the use of integral Luer ports. The apparatus may be produced, with minor adjustment, by using phototools.

    Monoclonal antibodies specific for buprenorphine and metabolites thereof
    4.
    发明授权
    Monoclonal antibodies specific for buprenorphine and metabolites thereof 有权
    对丁丙诺啡和其代谢物特异性的单克隆抗体

    公开(公告)号:US07195882B2

    公开(公告)日:2007-03-27

    申请号:US10453256

    申请日:2003-06-03

    摘要: The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine metabolite conjugates for the production of monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof and hybridoma cells that produce the monoclonal antibodies. The invention also relates to immunoassay methods for determining buprenorphine and/or one or more buprenorphine metabolites in a sample using the novel antibodies and conjugates of the present invention.

    摘要翻译: 本发明涉及特异性结合丁丙诺啡和/或其至少一种代谢产物的单克隆抗体。 本发明还涉及用于产生特异性结合丁丙诺啡和/或其至少一种代谢产物的单克隆抗体的丁丙诺啡代谢物缀合物和产生单克隆抗体的杂交瘤细胞。 本发明还涉及使用本发明的新抗体和缀合物测定样品中丁丙诺啡和/或一种或多种丁丙诺非代谢物的免疫测定方法。

    Device for determining an analyte in a sample
    5.
    发明授权
    Device for determining an analyte in a sample 失效
    用于确定样品中分析物的装置

    公开(公告)号:US5989924A

    公开(公告)日:1999-11-23

    申请号:US941184

    申请日:1997-09-30

    IPC分类号: G01N33/543 G01N33/5588

    摘要: The present invention relates to a device for determining an analyte in a fluid sample in an assay. The device comprises a lid having a plurality of elements and a membrane. The elements have openings which allow passage of fluid to the membrane. The membrane is supported by the lid and covers the openings of the elements. The undersurface of the membrane is in contact with a porous wick which contains a first zone which includes binder attached to a particulate label and a second zone containing salt. The wick extends downward from the membrane and is in contact with the fluid sample.

    摘要翻译: 本发明涉及用于在测定中测定流体样品中分析物的装置。 该装置包括具有多个元件和膜的盖。 这些元件具有允许流体通过膜的开口。 膜由盖支撑并覆盖元件的开口。 膜的下表面与多孔芯接触,多孔芯包括第一区,其包括附着于颗粒标签的粘合剂和含有盐的第二区。 芯从膜向下延伸并与流体样品接触。