利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.029 秒)

    Biologically active peptides and compositions, their use
    7.
    发明授权
    Biologically active peptides and compositions, their use 失效
    生物活性肽和组合物，其用途

    公开(公告)号：US6153590A

    公开(公告)日：2000-11-28

    申请号：US930584

    申请日：1998-02-02

    申请人： Raymond Andersen ,  John Coleman ,  Dilip De Silva ,  Fangming Kong ,  Edward Piers ,  Debra Wallace ,  Michel Roberge ,  Teresa Allen

    发明人： Raymond Andersen ,  John Coleman ,  Dilip De Silva ,  Fangming Kong ,  Edward Piers ,  Debra Wallace ,  Michel Roberge ,  Teresa Allen

    IPC分类号： A61K38/00 ,  A61P35/00 ,  C07K5/02 ,  C07K5/027 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083

    CPC分类号： C07K5/0205 ,  C07K5/0827 ,  A61K38/00

    摘要： Compounds of general formula I ##STR1## wherein: R.sub.1 and R.sub.70 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; R.sub.2 represents a hydrogen atom or an optionally substituted alkyl or acyl group or is absent when R.sub.6 represents a group --CH.dbd. as hereinafter described; R.sub.73 represents a hydrogen atom or an optional substituent or is absent when R.sub.6 represents a methylene group or a group --CH.dbd. as hereinafter described; Y represents an optional substituent; n represents 0, 1, 2, 3, or 4; R.sub.3 represents a hydrogen atom, or an optionally substituted alkyl group; R.sub.74 represents a hydrogen atom, a hydroxy group or an optionally substituted alkyl or acyl group; R.sub.7 represents a hydrogen atom or an alkyl group; R.sub.75 represents an optionally substituted alkyl group; and i) R.sub.6 and R.sub.71 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; and R.sub.72 represents a hydrogen atom; or ii) R.sub.71 represents a hydrogen atom or an optionally susbtituted alkyl or acyl group and R.sub.72 represents a hydrogen atom or R.sub.71 and R.sub.72 are joined together such that a double bond is formed between the carbon atoms to which they are attached; and R.sub.6 represents an optionally substituted methylene group bonded to the indole moiety thereby forming a tricyclic moiety; or R.sub.6 represents an optionally substituted group --CH.dbd. bonded to the indole moiety thereby to form an aromatic tricyclic moiety; for use in therapy and as antimitotic reagents are described.

    摘要翻译： PCT No.PCT / GB96 / 00942 Sec。 371日期1998年2月2日 102（e）1998年2月2日PCT 1996年4月22日PCT PCT。 出版物WO96 / 33211 日期：1996年10月24日通式I化合物其中：R 1和R 70独立地表示氢原子或任选取代的烷基或酰基; R2表示氢原子或任选取代的烷基或酰基，或当R6表示基团-CH =时不存在，如下所述; 当R 6表示亚甲基或-CH =如下所述时，R 73表示氢原子或任选的取代基或不存在; Y表示任选的取代基; n表示0,1,2,3或4; R3表示氢原子或任选取代的烷基; R 74表示氢原子，羟基或任选取代的烷基或酰基; R7表示氢原子或烷基; R75表示任选取代的烷基; 和i）R 6和R 71独立地表示氢原子或任选取代的烷基或酰基; R 72表示氢原子; 或ii）R 71表示氢原子或任选取代的烷基或酰基，R 72表示氢原子或R 71和R 72连接在一起，使得在它们所连接的碳原子之间形成双键; 并且R 6表示与吲哚部分键合的任选取代的亚甲基，从而形成三环部分; 或R6表示与吲哚部分键合的任选取代的基团-CH =，从而形成芳族三环部分; 用于治疗和用作抗有益剂的试剂。

    Ceratamines A and B, and Analogues, Syntheses and Pharmaceutical Compositions Thereof
    10.
    发明申请
    Ceratamines A and B, and Analogues, Syntheses and Pharmaceutical Compositions Thereof 审中-公开
    Ceratamines A和B及其类似物，合成和药物组合物

    公开(公告)号：US20080255090A1

    公开(公告)日：2008-10-16

    申请号：US10571932

    申请日：2004-09-15

    申请人： Raymond J. Andersen ,  Michel Roberge ,  Emiliano Manzo

    发明人： Raymond J. Andersen ,  Michel Roberge ,  Emiliano Manzo

    IPC分类号： C07D487/04 ,  A61K31/55 ,  A61P35/00

    CPC分类号： C07D487/04

    摘要： Antimitotic compounds and salts are provided in which the compound has the structure (formula (I)): wherein X and Y are substituted or unsubstituted and are selected from carbon atoms and atoms of groups 15 and 16 of the periodic table; Z is selected from N—R, O and S; U is selected from CR1, N, NH, NR, S and O, R1, R2, and R3 are independently selected from H, NH2, NHR, NR2, SH, SR, SiR3, OH, OR, F, CI, Br, I, ═O, ═S and R; W is selected from O, S, and H2; R4 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NR2 and halide; R is selected from H, substituted or unsubstituted aryl, and substituted or unsubstituted 1 to 20 carbon linear, branched, or cyclic, saturated or unsaturated alkyl, in which alkyl carbon atoms are replaced by 0 to 10 oxygen, 0 to 10 sulphur, and 0 to 10 N atoms; and wherein bonds to carbon atoms or to any of X, Y, Z and U are saturated or unsaturated; and providing that when W is H2, R4 is not H, OH, or unsubstituted phenyl.

    摘要翻译： 提供了其中化合物具有结构（式（I））的反仿构化合物和盐：其中X和Y是取代或未取代的，并且选自周期表第15和16族的碳原子和原子; Z选自N-R，O和S; U选自CR 1，N，NH，NR，S和O，R 1，R 2和R 3 独立地选自H，NH 2，NHR，NR 2，SH，SR，SiR 3，OH，OR， F，Cl，Br，I，-O，-S和R; W选自O，S和H 2; R 4选自H，R，OH，OR，SH，SR，NH 2，NHR，NR 2和卤素; R选自H，取代或未取代的芳基和取代或未取代的1至20个直链，支链或环状饱和或不饱和的烷基，其中烷基碳原子被0至10个氧，0至10个硫代替，以及 0〜10N原子; 并且其中与碳原子或X，Y，Z和U中的任一个的键是饱和或不饱和的; 并且当W是H 2 H时，R 4不是H，OH或未被取代的苯基。