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公开(公告)号：US06316439B1
公开(公告)日：2001-11-13
申请号：US08137444
申请日：1993-10-15
IPC分类号： C07D49106
CPC分类号： C07D491/10
摘要： This application relates to compounds of the formula wherein R1 is hydrogen, (C1-C12)alkylcarbonyl, (C1-C12)alkoxycarbonyl, aryl(C1-C12)alkylaminocarbonyl, mono(C1-C18)alkylaminocarbonyl or di(C1-C8)alkylaminocarbonyl; R2 is (C1-C12)alkylcarbonyloxy, aryl(C1-C4)alkylcarbonyloxy, (C1-C12)alkoxycarbonyloxy, arylcarbonyloxy, hydroxy, (C1-C6)alkoxycarbonyl(C1-C6)alkoxy or hydroxy(C1-C10)alkoxy; R3 is hydrogen or halo; and pharmaceutically acceptable addition salts; with the proviso that when R2 is hydroxy, R1 and R3 are not both hydrogen or when R2 is hydroxy and R3 is hydrogen, R1 is not methylcarbonyl; which compounds are useful for the treatment of memory dysfunction characterized by decreased cholinergic function, pharmaceutical compositions containing the compounds and methods for making and using the compounds.
摘要翻译： 本申请涉及式（Ⅳ）化合物，其中R1是氢，（C1-C12）烷基羰基，（C1-C12）烷氧基羰基，芳基（C1-C12）烷基氨基羰基，单（C1-C18）烷基氨基羰基或二（C1-C8）烷基氨基羰基; R2是（C1-C12）烷基羰基氧基，芳基（C1-C4）烷基羰基氧基，（C1-C12）烷氧基羰氧基，芳基羰基氧基，羟基，（C1-C6）烷氧羰基（C1-C6）烷氧基或羟基（C1-C10） 是氢或卤素; 和药学上可接受的加成盐; 条件是当R 2是羟基时，R 1和R 3不是氢或当R 2是羟基且R 3是氢时，R 1不是甲基羰基;这些化合物可用于治疗以胆碱能功能降低为特征的记忆功能障碍，含有 化合物的制备和使用方法。
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公开(公告)号：US06323195B1
公开(公告)日：2001-11-27
申请号：US08137440
申请日：1993-10-15
IPC分类号： C07D49106
CPC分类号： C07D491/10 , C07D491/06
摘要： This application relates to compounds of the formula wherein R1 is hydrogen, (C1-C12alkylcarbonyl, (C1-C12)alkoxycarbonyl, mono(C1-C12)alkylaminocarbonyl, or di(C1-C12)alkylaminocarbonyl; R2 is hydrogen, (C3-C12)alkenylcarbonyloxy, (C3-C12)cycloalkylcarbonyloxy, (C3-C12)cycloalkyl(C1-C12)alkylcarbonyloxy, oxygen containing heterocycloxy, oxygen containing heterocyclylcarbonyloxy, sulfur containing heterocyclyloxy, sulfur containing heterocyclylcarbonyloxy, nitrogen containing hetercyclyloxy, nitrogen containing heterocyclylcarbonyloxy, haloalkylsulfonyloxy, (C1-C6)alkylsilyloxy; R3 is hydrogen, halo or (C1-C4)alkyl; R4 is hydrogen or (C1-C6)alkyl; with the proviso that R1 and R2 are not both hydrogen when R3 and R4 are hydrogen; all geometric, and optical stereoisomers thereof, or a pharmaceutically acceptable addition salt thereof; which compounds are useful for the treatment of memory dysfunction characterized by decreased cholinergic function, pharmaceutical compositions containing the compounds and methods for making and using the compounds.
摘要翻译： 本申请涉及式（Ⅳ）的化合物是氢，（C1-C12烷基羰基，（C1-C12）烷氧基羰基，单（C1-C12）烷基氨基羰基或二（C1-C12）烷基氨基羰基; R2是氢，（C3-C12）烯基羰氧基 ，（C 3 -C 12）环烷基羰基氧基，（C 3 -C 12）环烷基（C 1 -C 12）烷基羰基氧基，含氧杂环氧基，含氧杂环基羰基氧基，含硫杂环基氧基，含硫杂环基羰基氧基，含氮杂环氧基，含氮杂环基羰基氧基，卤代烷基磺酰氧基，（C1- C6）烷基甲硅烷氧基; R3是氢，卤素或（C1-C4）烷基; R4是氢或（C1-C6）烷基;条件是当R3和R4是氢时，R1和R2不都是氢; 其光学立体异构体或其药学上可接受的加成盐;这些化合物可用于治疗以胆碱能功能降低为特征的记忆功能障碍，含有该组合物的药物组合物 制备和使用该化合物的方法和方法。
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公开(公告)号：US06323196B1
公开(公告)日：2001-11-27
申请号：US08137443
申请日：1993-10-15
IPC分类号： C07D49106
CPC分类号： C07D491/10
摘要： This application relates to compounds of the formula wherein R1 is hydrogen, (C1-C12)alkylcarbonyl, (C1-C12)alkoxycarbonyl, mono(C1-C12)alkylaminocarbonyl, or di(C1-C12)alkylaminocarbonyl; R2 is mono(C1-C18)alkylaminocarbonyloxy, di(C1-C8)alkylaminocarbonyloxy, or aryl(C1-C4)alkylaminocarbonyloxy; R3 is hydrogen or halo; or a pharmaceutically acceptable acid addition salt thereof, which compounds are useful for the treatment of memory dysfunction characterized by decreased cholinergic function, pharmaceutical compositions containing the compounds and methods for making and using the compounds.
摘要翻译： 本申请涉及式（Ⅳ）化合物，其中R1为氢，（C1-C12）烷基羰基，（C1-C12）烷氧基羰基，单（C1-C12）烷基氨基羰基或二（C1-C12）烷基氨基羰基; R2为单（C1-C18 ）烷基氨基羰基氧基，二（C1-C8）烷基氨基羰基氧基或芳基（C1-C4）烷基氨基羰基氧基; R3是氢或卤素; 或其药学上可接受的酸加成盐，所述化合物可用于治疗以胆碱能功能降低为特征的记忆功能障碍，含有该化合物的药物组合物以及制备和使用该化合物的方法。
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公开(公告)号：US5777108A
公开(公告)日：1998-07-07
申请号：US445921
申请日：1995-05-22
IPC分类号： C07D491/06 , A61K31/55 , A61K31/5517 , A61P25/28 , C07D223/00 , C07D307/00 , C07D491/048 , C07D491/10 , C07B41/04
CPC分类号： C07D491/10 , C07D491/06
摘要： This application relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined within, which compounds are useful for the treatment of memory dysfunction characterized by decreased cholinergic function, pharmaceutical compositions containing the compounds and methods for making and using the compounds.
摘要翻译： 本申请涉及下式化合物：其中R1，R2，R3和R4定义在其中，该化合物可用于治疗以胆碱能功能下降为特征的记忆功能障碍，含有化合物的药物组合物和制备和使用方法 化合物。
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公开(公告)号：US20130343642A1
公开(公告)日：2013-12-26
申请号：US13913685
申请日：2013-06-10
IPC分类号： G06K9/62
CPC分类号： G06K9/6256 , G06K9/4652
摘要： Automated person re-identification may be assisted by consideration of attributes of the person in a joint classification with matching of the person. By both solving for similarities in a plurality of attributes and identities, discriminative interactions may be captured. Automated person re-identification may be assisted by consideration of a semantic color name. Rather than a color histogram, probability distributions are mapped to color terms of the semantic color name. Using other descriptors as well, similarity measures for the various descriptors are weighted and combined into a score. Either or both considerations may be used.
摘要翻译： 自动人员重新识别可以通过考虑与人的匹配的联合分类中的人的属性来辅助。 通过解决多个属性和身份中的相似性，可以捕获歧视性交互。 可以通过考虑语义颜色名称来辅助自动人员重新识别。 概率分布不是颜色直方图，而是映射到语义颜色名称的颜色项。 还使用其他描述符，对各种描述符的相似性度量进行加权并组合成一个分数。 可以使用这两种或两种考虑因素。
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公开(公告)号：US20100199531A1
公开(公告)日：2010-08-12
申请号：US12533231
申请日：2009-07-31
申请人： STEVE BRETEY , Keith Kuhnly , Larry Davis
发明人： STEVE BRETEY , Keith Kuhnly , Larry Davis
CPC分类号： G06K19/041 , G06K19/07758 , G09F3/04 , G09F3/12
摘要： An improved animal tag for application to an animal's ear which comprises a male portion that includes a flat segment and a projection segment, a female portion that includes a generally square or generally oval shaped flat segment and a raised segment with an aperture; wherein the projection segment of the male portion is adapted to be inserted through the animal's ear and into the aperture when pressure is applied thereto.
摘要翻译： 一种用于动物耳朵的改进的动物标签，其包括包括平坦部分和突出部分的阳部分，包括大致正方形或大致椭圆形的平坦部分的阴部分和具有孔的凸起部分; 其中，当向其施加压力时，所述阳部分的所述突出部分适于插入所述动物的耳朵并进入所述孔。
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7.发明授权公开(公告)号：US06965622B1
公开(公告)日：2005-11-15
申请号：US10353242
申请日：2003-01-28
申请人： Si Hyung Cho , Ilya Lyubomirsky , Doyle Nichols , Gerald McAdoo , Larry Davis
发明人： Si Hyung Cho , Ilya Lyubomirsky , Doyle Nichols , Gerald McAdoo , Larry Davis
IPC分类号： H01S3/00 , H01S5/06 , H01S5/0687 , H01S5/12 , H04B10/155
CPC分类号： H04B10/572 , H01S5/0612 , H01S5/0687 , H01S5/12
摘要： The present invention is directed toward a laser wavelength locking scheme suitable for incorporation into WDM systems having channel spacings of 25 GHz or less. In a preferred embodiment, light output from the laser is supplied to a filtering element, such as an in-fiber Bragg grating or an etalon, and photodetectors are used to sense light transmitted through and either reflected by the filtering element or input to the filtering element. A measured ratio corresponding to a quotient of the photocurrents generated by the photodetectors is calculated and compared to a desired ratio corresponding to a measured temperature of the filtering element when the filtering element transmits the desired wavelength to be locked. Based on the comparison of the desired and measured ratios, a temperature error value is calculated which is used to adjust the laser temperature, as well as the laser wavelength. Accordingly, the temperature of the filtering element, for example, influences the laser temperature, so that wavelength variations stemming from temperature induced changes in the filtering element and other components in the laser package can be compensated, and the output wavelength can remain substantially fixed.
摘要翻译： 本发明涉及一种适用于掺入具有25GHz或更小的信道间隔的WDM系统的激光波长锁定方案。 在优选实施例中，从激光器输出的光被提供给诸如光纤内布拉格光栅或标准具的滤波元件，并且光电探测器用于感测透过的光，并且由滤光元件反射的光或者滤波器的输入 元件。 计算对应于由光电探测器产生的光电流的商的测量比，并将其与当滤波元件透过要锁定的期望波长时对应于滤波元件的测量温度的期望比率进行比较。 根据所需和比率的比较，计算用于调节激光温度以及激光波长的温度误差值。 因此，过滤元件的温度例如影响激光温度，从而可以补偿源自激光器封装中的过滤元件和其它部件的温度引起的变化引起的波长变化，并且输出波长可以保持基本上固定。
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公开(公告)号：US06604030B1
公开(公告)日：2003-08-05
申请号：US09589040
申请日：2000-06-06
申请人： Larry Davis , Dean Munson
发明人： Larry Davis , Dean Munson
IPC分类号： G06F700
CPC分类号： G08G5/0026 , G06F11/2007 , G06F11/2038 , G08G5/00
摘要： An integrated control and monitoring system for airport avionics is made single-point-of-failure impervious by continuously operating pairs of parallel-connected concentrators, Remote Master Workstations and Remote Slave Workstations, and a pair of independent LANs each connecting one of the concentrators of a pair to the Remote Workstations. Each concentrator of a concentrator pair, while in secondary status, monitors the operation of the concentrator in primary status, and whenever it observes a failure of communication will assume primary status and continue to allow ICMS to function in a normal manner. Likewise, another Remote Master Workstation automatically assumes Remote Master Workstation status if it fails to see an operational active master station on the network.
摘要翻译： 通过连续运行并联集线器，远程主站工作站和远程从站工作站以及一对独立的LAN，将机场航空电子综合控制和监控系统设置为单点故障防护，每个连接一个集中器 一对远程工作站。 集中器对的每个集中器在二级状态下监视集中器的主要状态的操作，并且只要它观察到通信故障将承担主要状态并且继续允许ICMS以正常的方式工作。 同样，另一个远程主站工作站如果无法在网络上看到运行的主动主站时，将自动假定为远程主站工作站状态。
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公开(公告)号：US5214058A
公开(公告)日：1993-05-25
申请号：US722465
申请日：1991-06-27
申请人： Richard C. Effland , Larry Davis , Gordon E. Olsen
发明人： Richard C. Effland , Larry Davis , Gordon E. Olsen
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： This invention relates to compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, loweralkyl, arylloweralkyl, loweralkenyl or loweralkynyl;R.sub.2 is hydrogen, loweralkyl, loweralkenyl, formyl or cyano;X is hydrogen, halogen, nitro, amino, loweralkyl, loweralkoxy or hydroxy;Y is hydrogen, loweralkyl, loweralkoxy, arylloweralkoxy, hydroxy, halogen, nitro or amino, with the proviso that when Y is hydrogen or loweralkyl, R.sub.1 is not hydrogen and R.sub.2 is not formyl; a pharmaceutically acceptable acid addition salt thereof, or where applicable, a geometric or optical isomer or racemic mixture thereof. The compounds of the invention are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function, such as found in Alzheimer's disease and other senile dementia.
摘要翻译： 本发明涉及下式化合物：其中R 1是氢，低级烷基，芳基低级烷基，低级烯基或低级炔基; R2是氢，低级烷基，低级烯基，甲酰基或氰基; X是氢，卤素，硝基，氨基，低级烷基，低级烷氧基或羟基; Y是氢，低级烷基，低级烷氧基，芳基低级烷氧基，羟基，卤素，硝基或氨基，条件是当Y是氢或低级烷基时，R1不是氢，R2不是甲酰基; 其药学上可接受的酸加成盐，或适用时为其几何或旋光异构体或外消旋混合物。 本发明的化合物可用于治疗特征在于胆碱能功能降低的各种记忆功能障碍，例如在阿尔茨海默病和其他老年痴呆中发现的。
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公开(公告)号：US5015637A
公开(公告)日：1991-05-14
申请号：US529082
申请日：1990-05-25
申请人： Richard C. Effland , Larry Davis
发明人： Richard C. Effland , Larry Davis
IPC分类号： A61K31/55 , A61K31/553 , A61P25/04 , C07D498/14
CPC分类号： C07D498/14
摘要： There are disclosed various compounds of the formula below, ##STR1## where X is hydrogen, halogen or loweralkyl;Y is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl;R.sub.1 is hydrogen, loweralkyl, aryl, arylloweralkyl, diloweralkylaminoloweralkyl or ##STR2## R.sub.3 being hydrogen, loweralkyl or arylloweralkyl; and R.sub.2 is hydrogen, loweralkyl or arylloweralkyl;which compounds are useful as analgesic agents.
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