公开(公告)号：US06241662B1

公开(公告)日：2001-06-05

申请号：US09175232

申请日：1998-10-20

申请人： Rebecca Richards-Kortum ,  Anant Agrawal ,  Costas Pitris ,  Urs Utzinger ,  Carrie Brookner ,  Michele Follen Mitchell

发明人： Rebecca Richards-Kortum ,  Anant Agrawal ,  Costas Pitris ,  Urs Utzinger ,  Carrie Brookner ,  Michele Follen Mitchell

IPC分类号： A61B500

CPC分类号： G01N33/52 ,  A61B5/0071 ,  A61B5/4331 ,  G01N1/30 ,  G01N2015/1488

摘要： A method for using acetic acid as a signal enhancing contrast agent during fluorescence spectroscopy of normal and neoplastic tissue, particularly epithelium. In one aspect, the invention includes a method of detecting tissue abnormality in a diagnostic tissue sample in a patient, comprising the steps of obtaining a first fluorescence intensity spectrum from the diagnostic tissue sample; thereafter, applying acetic acid to the diagnostic tissue sample in sufficient concentration to alter the response of such diagnostic tissue sample to electromagnetic radiation for at least an effective period of time; during the effective period of time, obtaining a second fluorescence intensity spectrum from the diagnostic tissue sample; determining a parameter indicative of a change between the first and second fluorescence emission intensity spectra; and analyzing the determined parameter to determine a probability that the diagnostic tissue sample is normal or abnormal.

摘要翻译： 在正常和肿瘤组织，特别是上皮的荧光光谱学过程中使用乙酸作为信号增强造影剂的方法。 一方面，本发明包括检测患者的诊断性组织样本中的组织异常的方法，包括以下步骤：从所述诊断组织样品获得第一荧光强度光谱; 此后，以足够的浓度将乙酸施用于诊断组织样品，以将这种诊断性组织样品的响应改变为电磁辐射至少有效的一段时间; 在有效时间段内，从诊断组织样品获得第二荧光强度光谱; 确定指示所述第一和第二荧光发射强度光谱之间的变化的参数; 并分析确定的参数以确定诊断组织样本正常或异常的概率。

公开(公告)号：US5699795A

公开(公告)日：1997-12-23

申请号：US415356

申请日：1995-03-31

申请人： Rebecca Richards-Kortum ,  Costas Pitris ,  Michele Follen Mitchell

发明人： Rebecca Richards-Kortum ,  Costas Pitris ,  Michele Follen Mitchell

IPC分类号： A61B5/00 ,  A61B10/00 ,  A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/4331 ,  A61B5/0075

摘要： A probe, and an apparatus incorporating the probe, for detecting tissue abnormality, particularly precancerous cervical tissue, through fluorescence spectroscopy are disclosed. In vivo fluorescence excitation and detection can be accomplished easily and accurately using a probe whose tip conforms to the surface of the cervix. In addition, a higher number of fiber pairs provides more information and, therefore, more accurate diagnosis.

摘要翻译： 公开了一种用于通过荧光光谱法检测组织异常，特别是癌前期宫颈组织的探针和结合有探针的装置。 可以使用尖端符合子宫颈表面的探针，容易且准确地实现体内荧光激发和检测。 此外，更多数量的光纤对提供更多信息，因此提供更准确的诊断。

公开(公告)号：US09890187B2

公开(公告)日：2018-02-13

申请号：US14751795

申请日：2015-06-26

申请人： Andreani Odysseos ,  Costas Pitris ,  Anastasios Keramidas

发明人： Andreani Odysseos ,  Costas Pitris ,  Anastasios Keramidas

IPC分类号： C07F15/00 ,  A61K49/00

CPC分类号： C07F15/0053 ,  A61K49/0021 ,  A61K49/0052

摘要： The present invention relates to a theranostic system comprising a beacon and a compound selected from the group consisting of a quinazoline-based tyrosine kinase inhibitor and a natural product. The theranostic systems have use in the therapy and diagnosis of tyrosine kinase related malignancies.