公开(公告)号：US20180168917A1

公开(公告)日：2018-06-21

申请号：US15845602

申请日：2017-12-18

Applicant: Regents of the University of Minnesota

Inventor： Khalafalla Bushara

IPC: A61H9/00 ,  A61H7/00

CPC classification number: A61H9/0085 ,  A61H7/001 ,  A61H7/007 ,  A61H2201/1284 ,  A61H2201/164 ,  A61H2201/165 ,  A61H2205/102 ,  A61H2205/12 ,  A61H2205/125

Abstract: A device can comprise: a trigger chamber, having a trigger elastic wall and a trigger base wall, the trigger chamber configured for relative motion between the trigger elastic wall and the trigger base wall; a connecting line fluidly coupled to the trigger chamber, the connecting line having a substantially inelastic wall; a stimulation chamber fluidly coupled to the connecting line, the stimulation chamber having a stimulation elastic wall and a stimulation base wall, the stimulation chamber configured for relative motion between the stimulation elastic wall and the stimulation base wall, the stimulation elastic wall having an exterior surface; a plurality of projections coupled to the exterior surface; and a stabilizing frame, the stabilizing frame having a substantially rigid wall, the stabilizing frame having a plurality of apertures, the stabilizing frame extending over the stimulation chamber, the projections configured to extend through the apertures when the stimulation chamber is expanded.

公开(公告)号：US10772791B2

公开(公告)日：2020-09-15

申请号：US15845602

申请日：2017-12-18

Applicant: Regents of the University of Minnesota

Inventor： Khalafalla Bushara

IPC: A61H9/00 ,  A61H7/00

Abstract: A device can comprise: a trigger chamber, having a trigger elastic wall and a trigger base wall, the trigger chamber configured for relative motion between the trigger elastic wall and the trigger base wall; a connecting line fluidly coupled to the trigger chamber, the connecting line having a substantially inelastic wall; a stimulation chamber fluidly coupled to the connecting line, the stimulation chamber having a stimulation elastic wall and a stimulation base wall, the stimulation chamber configured for relative motion between the stimulation elastic wall and the stimulation base wall, the stimulation elastic wall having an exterior surface; a plurality of projections coupled to the exterior surface; and a stabilizing frame, the stabilizing frame having a substantially rigid wall, the stabilizing frame having a plurality of apertures, the stabilizing frame extending over the stimulation chamber, the projections configured to extend through the apertures when the stimulation chamber is expanded.

公开(公告)号：US12161755B2

公开(公告)日：2024-12-10

申请号：US17526609

申请日：2021-11-15

Applicant: Regents of the University of Minnesota

Inventor： Khalafalla Bushara

IPC: A61K9/00 ,  A61K31/198 ,  A61K47/12

Abstract: Provided herewith is a device having one sachet or more than one nested sachet with the largest sachet made of, e.g., a non-dissolvable, porous, wettable and non-toxic material. The sachets are filled with a desired combination of medications and excipients to provide sustained dosing, blood levels and effects of the said combination of medications. The sachets can be arranged in such a configuration to be suitable for placement in the oral/buccal cavity with comfort and to deliver, e.g., continuous or on-demand release of the desired medications for both transmucosal and gastrointestinal absorption. Also provided are containers for such devices.

公开(公告)号：US20220175662A1

公开(公告)日：2022-06-09

申请号：US17526609

申请日：2021-11-15

Applicant: Regents of the University of Minnesota

Inventor： Khalafalla Bushara

IPC: A61K9/00

Abstract: Provided herewith is a device having one sachet or more than one nested sachet with the largest sachet made of, e.g., a non-dissolvable, porous, wettable and non-toxic material. The sachets are filled with a desired combination of medications and excipients to provide sustained dosing, blood levels and effects of the said combination of medications. The sachets can be arranged in such a configuration to be suitable for placement in the oral/buccal cavity with comfort and to deliver, e.g.. continuous or on-demand release of the desired medications for both transmucosal and gastrointestinal absorption. Also provided are containers for such devices.

公开(公告)号：US09867758B2

公开(公告)日：2018-01-16

申请号：US14602046

申请日：2015-01-21

Applicant: Regents of the University of Minnesota

Inventor： Khalafalla Bushara

IPC: A61H11/00 ,  A61H9/00 ,  A61H7/00

CPC classification number: A61H9/0085 ,  A61H7/001 ,  A61H7/007 ,  A61H2201/1284 ,  A61H2201/164 ,  A61H2201/165 ,  A61H2205/102 ,  A61H2205/12 ,  A61H2205/125

Abstract: A device can comprise: a trigger chamber, having a trigger elastic wall and a trigger base wall, the trigger chamber configured for relative motion between the trigger elastic wall and the trigger base wall; a connecting line fluidly coupled to the trigger chamber, the connecting line having a substantially inelastic wall; a stimulation chamber fluidly coupled to the connecting line, the stimulation chamber having a stimulation elastic wall and a stimulation base wall, the stimulation chamber configured for relative motion between the stimulation elastic wall and the stimulation base wall, the stimulation elastic wall having an exterior surface; a plurality of projections coupled to the exterior surface; and a stabilizing frame, the stabilizing frame having a substantially rigid wall, the stabilizing frame having a plurality of apertures, the stabilizing frame extending over the stimulation chamber, the projections configured to extend through the apertures when the stimulation chamber is expanded.