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公开(公告)号：US06635049B1
公开(公告)日：2003-10-21
申请号：US09303790
申请日：1999-04-30
IPC分类号： A61K922
CPC分类号： A61M5/14276 , A61M5/16809 , A61M5/1723 , A61M2230/04
摘要： An bolus delivery system includes an implantable pump, a sensor for sensing an adverse patient condition, such as atrial fibrillation, and a catheter for delivery of a bolus of drug to a target area of a living body. The pump is provided with a bolus metering assembly which includes, in a preferred embodiment, an auxiliary bellows defining a bolus reservoir in addition to the main reservoir of the pump. The auxiliary bellows is selectively placed in fluid communication with the pressurized main supply of drug via an inlet valve to refill the bolus reservoir. An outlet valve is provided to permit egress of the bolus to the catheter from the bolus reservoir. A drive train including a stepper motor and a face cam selectively opens and closes the inlet and outlet valves to effect accumulation or metering and delivery of the bolus. The auxiliary bellows is preferably provided as a collapsible element resiliently biased to an expanded position and is collapsed under pressure in the main reservoir to expel the bolus.
摘要翻译： 推注递送系统包括可植入泵，用于感测诸如心房颤动的不利患者状况的传感器，以及用于将药物推送到活体的靶区域的导管。 该泵具有推注计量组件，在优选实施例中，除了泵的主容器之外，还包括限定推注储液器的辅助波纹管。 辅助波纹管通过入口阀选择性地与加压的主药物流体连通以重新填充推注储液器。 提供出口阀以允许推注从推注储存器导出到导管。 包括步进马达和面凸轮的传动系选择性地打开和关闭入口和出口阀，以实现弹丸的积聚或计量和输送。 辅助波纹管优选地设置为可弹性偏置到扩张位置的可折叠元件，并且在主储器中在压力下塌缩以排出推注。
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公开(公告)号：US5551849A
公开(公告)日：1996-09-03
申请号：US235436
申请日：1994-04-29
IPC分类号： A61M5/142 , F04B45/033 , A61M5/152
CPC分类号： A61M5/14276
摘要： A medication delivery device having a reduced weight due to the configuration of the end terminal of the pleated bellows reservoir. The end terminal includes an indented portion which is sized such that when the reservoir is in the compressed/empty position there is substantially no separation between the indented portion and the base portion of the reservoir. This construction allows the reservoir to be almost completely emptied of medication when the reservoir is collapsed but does so in a manner which does not add to the weight of the device.
摘要翻译： 一种药物输送装置，由于褶皱波纹管储存器的端部端子的结构而具有减轻的重量。 端部端子包括凹口部分，其尺寸使得当储存器处于压缩/空的位置时，凹槽部分和储存器的基部之间基本上没有间隔。 这种结构允许储存器在储存器折叠时几乎完全清空药物，但以不增加装置重量的方式进行。
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公开(公告)号：US5443450A
公开(公告)日：1995-08-22
申请号：US235442
申请日：1994-04-29
CPC分类号： A61M5/14276
摘要： A medication delivery device having a particularly compact size due to the bulged configuration of the cover. The device includes a housing having a base and a cover. The cover includes a side portion and a substantially planer surface joined by a curved portion. The curved portion is bulged outwardly in a manner such that the area of the internal cavity bounded by the side portion, the substantially planer surface and the base includes substantially all of the area which would be formed if the side portion and the substantially planer surface were extended and joined in the absence of the curved portion. This enables the entire vertical space of the internal cavity to be utilized and allows the thickness of the device to be minimized.
摘要翻译： 一种药物输送装置，由于罩的凸起构型而具有特别紧凑的尺寸。 该装置包括具有底座和盖子的壳体。 所述盖包括由弯曲部分连接的侧部和大致平坦的表面。 弯曲部分以这样的方式向外凸出，使得由侧部，基本上平的表面和基部限定的内部空腔的面积基本上包括如果侧部和大致平坦的表面是 在没有弯曲部分的情况下延伸并连接。 这使得能够利用内腔的整个垂直空间，并且允许使装置的厚度最小化。
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公开(公告)号：US06685452B2
公开(公告)日：2004-02-03
申请号：US09925598
申请日：2001-08-09
IPC分类号： F04B3900
CPC分类号： A61M5/14276
摘要： A human body implantable drug delivery pump has a housing including at least a first shield and a second shield. The housing defines an interior within the shields. The pump further includes a fluid reservoir within the housing, a fluid conduit also within the housing from the reservoir, an outlet from the fluid conduit to the exterior of the housing, and a pump member in the housing adapted to move fluid through the fluid conduit to the outlet. The fluid in the reservoir and fluid conduit is isolated from the pump interior. The pump further has a desiccant in the pump interior, the desiccant absorbent of moisture in the pump interior, and preferably absorbent of substantially all the moisture in the pump interior. The desiccant also preferably has a moisture absorbent property dependent on temperature, being lessened at higher temperatures, the desiccant being pre-baked to improve its moisture absorbent property before being placed in the pump.
摘要翻译： 人体可植入药物输送泵具有至少包括第一屏蔽和第二屏蔽的壳体。 壳体限定了屏蔽内的内部。 所述泵还包括在所述壳体内的流体贮存器，还存在从所述容器的壳体内的流体导管，从所述流体导管到所述壳体的外部的出口以及所述壳体中的泵构件，其适于将流体移动通过所述流体导管 到出口。 储存器和流体导管中的流体与泵内部隔离。 泵还在泵内部具有干燥剂，泵内部的湿气的干燥剂吸收剂，并且优选地在泵内部基本上吸收所有的水分。 干燥剂还优选具有取决于温度的吸湿性，在较高温度下减弱，干燥剂被预烘烤以在放入泵之前改善其吸湿性能。
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公开(公告)号：US08473057B2
公开(公告)日：2013-06-25
申请号：US12609901
申请日：2009-10-30
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/08 , A61N1/36114 , A61N1/37 , A61N1/3718 , A61N1/37211 , A61N1/37288 , A61N1/3925 , A61N1/3962
摘要： Techniques for minimizing interference between first and second medical devices of a therapy system may include providing an outer housing for at least one of the medical devices that comprises an electrically insulative layer formed over at least the electrically conductive portions (e.g., an electrically conductive layer) of the housing, or providing an electrically insulative pouch around an electrically conductive housing of at least the first medical device. The electrically insulative layer or electrically insulative pouch may reduce or even eliminate shunt-current that flows into the medical device via the housing. The shunt-current may be generated by the delivery of electrical stimulation by the second medical device. In some examples, the techniques may also include shunt-current mitigation circuitry that helps minimize or even eliminate shunt-current that feeds into the first medical device via one or more electrodes electrically connected to the first medical device.
摘要翻译： 用于最小化治疗系统的第一和第二医疗装置之间的干扰的技术可以包括提供用于至少一个医疗装置的外壳，其包括在至少导电部分（例如，导电层）上形成的电绝缘层， 或者提供围绕至少第一医疗装置的导电外壳的电绝缘袋。 电绝缘层或电绝缘袋可以减少甚至消除通过外壳流入医疗装置的分流电流。 分流电流可以通过第二医疗装置的电刺激的传递来产生。 在一些示例中，所述技术还可以包括分流电流缓解电路，其帮助最小化或甚至消除通过电连接到第一医疗设备的一个或多个电极馈入第一医疗设备的分流电流。
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公开(公告)号：US20100114205A1
公开(公告)日：2010-05-06
申请号：US12609901
申请日：2009-10-30
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/08 , A61N1/36114 , A61N1/37 , A61N1/3718 , A61N1/37211 , A61N1/37288 , A61N1/3925 , A61N1/3962
摘要： Techniques for minimizing interference between first and second medical devices of a therapy system may include providing an outer housing for at least one of the medical devices that comprises an electrically insulative layer formed over at least the electrically conductive portions (e.g., an electrically conductive layer) of the housing, or providing an electrically insulative pouch around an electrically conductive housing of at least the first medical device. The electrically insulative layer or electrically insulative pouch may reduce or even eliminate shunt-current that flows into the medical device via the housing. The shunt-current may be generated by the delivery of electrical stimulation by the second medical device. In some examples, the techniques may also include shunt-current mitigation circuitry that helps minimize or even eliminate shunt-current that feeds into the first medical device via one or more electrodes electrically connected to the first medical device.
摘要翻译： 用于最小化治疗系统的第一和第二医疗装置之间的干扰的技术可以包括提供用于至少一个医疗装置的外壳，其包括在至少导电部分（例如，导电层）上形成的电绝缘层， 或者在至少第一医疗装置的导电外壳周围提供电绝缘袋。 电绝缘层或电绝缘袋可以减少甚至消除通过外壳流入医疗装置的分流电流。 分流电流可以通过第二医疗装置的电刺激的传递来产生。 在一些示例中，所述技术还可以包括分流电流缓解电路，其帮助最小化或甚至消除通过电连接到第一医疗设备的一个或多个电极馈入第一医疗设备的分流电流。
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公开(公告)号：US06663609B2
公开(公告)日：2003-12-16
申请号：US10014634
申请日：2001-10-22
IPC分类号： A61M3100
CPC分类号： A61M5/14276 , A61M5/14586 , A61M39/0208 , A61M2209/045 , Y10S128/12
摘要： A device and method configured for placement into the catheter access port to prevent insertion of a needle into the catheter access port. The device a prong to engage the housing and lock itself in the catheter access port, an annular surface having geometry complimentary to the catheter access port to seal the denial device, and a face configured to deny needle access to the catheter access port. The device is also self sealing to substantial prevent deposition between itself and the catheter access port, is configured to be inserted without the need for tools, and is manufactured from biocompatible material. The method for inserting this device consists of aligning the device with the catheter access port, inserting the device, confirming it is in place, and sealing it into the catheter access port.
摘要翻译： 一种被配置为放置在导管进入口中以防止将针插入导管进入端口中的装置和方法。 该装置具有接合外壳并将其自身锁定在导管进入端口中的插脚，具有与导管进入端口互补的几何形状以密封拒绝装置的环形表面，以及被配置为拒绝针进入导管进入端口的面。 该装置也是自密封的，以显着地防止其自身与导管进入口之间的沉积，被构造为插入而不需要工具，并且由生物相容性材料制成。 用于插入该装置的方法包括将装置与导管进入口对准，插入装置，确认其就位，并将其密封到导管进入口中。
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8.发明授权公开(公告)号：US06238367B1
公开(公告)日：2001-05-29
申请号：US09561538
申请日：2000-04-28
IPC分类号： A61M1100
CPC分类号： A61M5/14276 , A61M5/14232 , A61M2205/8206 , Y10S128/12
摘要： An implantable drug infusion device includes a bulkhead having a chamber and a shield for the bulkhead. A transducer is secured to the shield. An electronic module is located in the bulkhead for controlling operation of a pump assembly. A biasing member is in electrical contact with the electronic module and the transducer such that current transmitted from the electronic module to the transducer through the biasing member actuates the transducer.
摘要翻译： 可植入药物输注装置包括具有室的隔板和用于隔板的屏蔽件。 传感器固定在屏蔽上。 电子模块位于隔板中，用于控制泵组件的操作。 偏置构件与电子模块和换能器电接触，使得通过偏压构件从电子模块传递到换能器的电流驱动换能器。
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