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    Porous coatings for drug release from medical devices
    2.
    发明申请
    Porous coatings for drug release from medical devices 审中-公开
    从医疗器械释放药物的多孔涂层

    公开(公告)号：US20050079199A1

    公开(公告)日：2005-04-14

    申请号：US10933734

    申请日：2004-09-03

    申请人： Kenneth Heruth ,  Edouard Koullick ,  Mark Lent

    发明人： Kenneth Heruth ,  Edouard Koullick ,  Mark Lent

    IPC分类号： A61K9/50 ,  A61M5/00 ,  A61M27/00 ,  A61M29/00

    CPC分类号： A61M27/006

    摘要： Extravascular implantable medical devices are described. The devices include a polymeric layer comprising a polymeric matrix and pores. Therapeutic agent is loaded in the matrix, in the pores, or in the matrix and the pores. The devices include a structural surface layer. Additional therapeutic agent may be loaded in or on the surface layer. The devices may also include one or more intermediate layer, into or onto which additional therapeutic agent may be loaded.

    摘要翻译： 描述了血管内可植入医疗装置。 所述装置包括聚合物层，其包含聚合物基质和孔。 治疗剂加载到基质，孔中或基质和孔中。 这些装置包括结构表面层。 另外的治疗剂可以装载在表面层中或表面层上。 装置还可以包括一个或多个中间层，可以加载另外的治疗剂。

    MEDICAL ELECTRICAL LEAD CONNECTION SYSTEMS AND METHODS
    3.
    发明申请
    MEDICAL ELECTRICAL LEAD CONNECTION SYSTEMS AND METHODS 有权
    医用电线连接系统及方法

    公开(公告)号：US20090247018A1

    公开(公告)日：2009-10-01

    申请号：US12482033

    申请日：2009-06-10

    申请人： John Kast ,  Mark Lent ,  Jim Olsen ,  Andrew Ries ,  James Skakoon ,  Carl Wahlstrand

    发明人： John Kast ,  Mark Lent ,  Jim Olsen ,  Andrew Ries ,  James Skakoon ,  Carl Wahlstrand

    IPC分类号： H01R33/00 ,  H01R24/00

    CPC分类号： H01R13/502 ,  A61N1/3752 ,  H01R13/193 ,  H01R13/5224 ,  H01R24/58 ,  H01R2107/00 ,  H01R2201/12 ,  Y10S439/909

    摘要： An electrical connection assembly of a medical device includes a plurality of electrical contact blocks and a sealing member, which are held within a cavity of a base of the assembly. The sealing member includes a plurality of openings, at least one interior surface surrounding a bore and at least one void. Each electrical contact block extends into a corresponding opening of the sealing member, and a conductive sidewall of each block defines a portion of a perimeter of an area for receiving a lead connector, while the bore of the sealing member forms another portion of the perimeter of the area. The at least one void provides a compressible space in a bulk volume of the sealing member. When the lead is inserted within the area, and a cap is engaged with the base, the at least one interior surface of the sealing member is compressed about the lead.

    摘要翻译： 医疗装置的电连接组件包括多个电接触块和密封构件，所述密封构件保持在组件的基座的空腔内。 密封构件包括多个开口，围绕孔和至少一个空隙的至少一个内表面。 每个电接触块延伸到密封构件的对应的开口中，并且每个块的导电侧壁限定用于容纳引线连接器的区域的周边的一部分，同时密封构件的孔形成周边的另一部分 该地区。 至少一个空隙在密封构件的本体体积中提供可压缩空间。 当引线插入区域内并且帽与基座接合时，密封构件的至少一个内表面围绕引线被压缩。

    Regional therapies for treatment of pain
    5.
    发明申请
    Regional therapies for treatment of pain 有权
    治疗疼痛的区域疗法

    公开(公告)号：US20070021802A1

    公开(公告)日：2007-01-25

    申请号：US11375492

    申请日：2006-03-14

    申请人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel

    发明人： Kenneth Heruth ,  Mark Lent ,  Ruchika Singhal ,  Michael Schendel

    IPC分类号： A61N1/34

    CPC分类号： A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2205/3523 ,  A61N1/025 ,  A61N1/36071 ,  A61N1/372 ,  A61N1/37229

    摘要： Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The therapies further include administering a pain treating agent at a predetermined time relative to application of the high or low frequency stimulation. Delivery of the pain treating agent via an implantable infusion system is described. Coordination of output of an infusion device and a pulse generator to provide coordinated therapy is also discussed.

    摘要翻译： 描述了治疗疼痛的增强疗法。 这些疗法包括在低频（小于约20Hz）和高频（大于约50Hz）的疼痛源附近皮下刺激组织。 所述疗法还包括相对于施用高频或低频刺激而在预定时间施用疼痛治疗剂。 描述了通过植入式输注系统递送疼痛治疗剂。 还讨论了输液装置和脉冲发生器的输出协调以提供协调治疗。

    Anti-infective medical device
    8.
    发明申请
    Anti-infective medical device 有权
    抗感染医疗器械

    公开(公告)号：US20060009806A1

    公开(公告)日：2006-01-12

    申请号：US11008445

    申请日：2004-12-09

    申请人： Kenneth Heruth ,  Christopher Hobot ,  William Hooper ,  Mark Lent ,  Ruchika Singhal ,  Robert Skime ,  Randall Sparer ,  Maura Donovan ,  William Bertrand

    发明人： Kenneth Heruth ,  Christopher Hobot ,  William Hooper ,  Mark Lent ,  Ruchika Singhal ,  Robert Skime ,  Randall Sparer ,  Maura Donovan ,  William Bertrand

    IPC分类号： A61N1/18

    CPC分类号： A61N1/05 ,  A61N1/0568 ,  A61N1/375

    摘要： Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.

    摘要翻译： 描述具有抗感染性的植入式医疗装置（IMDS）。 抗感染剂设置在医疗装置的表面的至少一部分上，其上或附近。 抗感染剂设置在车辆中或车辆上，其可以是涂层或覆盖物的形式。 载体可以是可生物降解的，使得随着时间的推移，抗感染剂从植入装置所在的组织位置移除，降低了抗感染剂抗微生物的可能性。 还描述了其上设置有抗感染剂和抗活性剂的IMD，其上或其上。 干扰抗感染剂的活性的抗活性剂可以在不再需要抗感染剂的活性的时候从IMD的表面释放，并且可能降低抗微生物抗性的可能性 抗感染剂会发展。

    Catheters with tracking elements and permeable membranes
    9.
    发明申请
    Catheters with tracking elements and permeable membranes 有权
    导管带跟踪元件和渗透膜

    公开(公告)号：US20050137577A1

    公开(公告)日：2005-06-23

    申请号：US10873764

    申请日：2004-06-22

    申请人： Kenneth Heruth ,  Mark Lent ,  Justin Blanco

    发明人： Kenneth Heruth ,  Mark Lent ,  Justin Blanco

    IPC分类号： A61M25/00 ,  A61M25/16

    CPC分类号： A61M25/0043 ,  A61M25/003 ,  A61M25/0105 ,  A61M2025/0057 ,  A61M2025/0166

    摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes and one or more tracking elements that may be used to place the infusions sections on the catheters in selected locations such as the spinal region.

    摘要翻译： 公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。 在各个方面，系统和方法可以包括具有可渗透膜的输注部分的导管和一个或多个跟踪元件，所述跟踪元件可用于将选定位置（例如脊柱区域）中的输液部分置于导管上。