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公开(公告)号:US07368535B2
公开(公告)日:2008-05-06
申请号:US10477525
申请日:2002-05-24
IPC分类号: C07K14/47 , C07K14/725 , C07K16/46
CPC分类号: G01N33/505 , A61K38/00 , A61K48/00 , A61K2035/122 , A61K2039/505 , A61K2039/5154 , A61K2039/5158 , C07K14/70503 , C07K14/70596 , C07K16/2803 , C07K2317/34 , C07K2317/54 , C07K2319/00 , C07K2319/30 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5047 , G01N33/566 , G01N2500/04 , G01N2500/20
摘要: The present invention relates to CD200 receptor isoforms and modulators thereof and their use in methods of immune modulation and pharmaceutical compositions.
摘要翻译: 本发明涉及CD200受体亚型及其调节剂及其在免疫调节和药物组合物的方法中的用途。
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公开(公告)号:US06642433B1
公开(公告)日:2003-11-04
申请号:US09689872
申请日:2000-10-13
申请人: Gary Levy , Philip Marsden , Laisum Fung
发明人: Gary Levy , Philip Marsden , Laisum Fung
IPC分类号: A01K67027
CPC分类号: C07K16/40 , A01K67/0276 , A01K2217/075 , A01K2267/03 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/647 , C12N15/8509 , C12N2799/026 , G01N33/6893 , G01N33/86 , G01N2800/224
摘要: A knockout mouse in which the Fgl-2 gene has been suppressed is described. The mouse is useful in studying the role of Fgl-2 in normal and disease states including viral hepatitis, allograph rejection, fetal loss, inflammatory bowel disease, lupus glomerulonephritis; acute respiratory disease syndrome, Whipple's disease, cancer and for developing therapies to treat these diseases.
摘要翻译: 描述了Fgl-2基因被抑制的敲除小鼠。 该小鼠可用于研究Fgl-2在正常和疾病状态中的作用,包括病毒性肝炎,同种异体排斥反应,胎儿丧失,炎性肠病,狼疮肾小球性肾炎; 急性呼吸道疾病综合征,惠普尔病,癌症以及开发治疗这些疾病的治疗方法。
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公开(公告)号:US20050107314A1
公开(公告)日:2005-05-19
申请号:US10477525
申请日:2002-05-24
IPC分类号: A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705 , C07K16/28 , C12N5/08 , C12N15/12 , G01N33/50 , G01N33/566 , C12Q1/68 , C07H21/04 , C07K14/74
CPC分类号: G01N33/505 , A61K38/00 , A61K48/00 , A61K2035/122 , A61K2039/505 , A61K2039/5154 , A61K2039/5158 , C07K14/70503 , C07K14/70596 , C07K16/2803 , C07K2317/34 , C07K2317/54 , C07K2319/00 , C07K2319/30 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5047 , G01N33/566 , G01N2500/04 , G01N2500/20
摘要: The present invention relates to CD200 receptor isoforms and modulators thereof and their use in methods of immune modulation and pharmaceutical compositions.
摘要翻译: 本发明涉及CD200受体亚型及其调节剂及其在免疫调节和药物组合物的方法中的用途。
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公开(公告)号:US20050042226A1
公开(公告)日:2005-02-24
申请号:US10875528
申请日:2004-06-25
申请人: Gary Levy , Philip Marsden
发明人: Gary Levy , Philip Marsden
IPC分类号: A61K39/395 , A61P31/20 , C07K14/75 , C07K16/08 , C07K16/40 , C12N15/85 , C12Q1/68 , A61K39/42
CPC分类号: A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0337 , A61K2039/505 , C07K14/75 , C07K16/40 , C12N15/8509
摘要: The use of Fgl2 inhibitors to treat and control the progression of human Hepatitis B virus-induced hepatitis is described. Inhibitors of Fgl2 include antibodies to Fgl2.
摘要翻译: 描述了使用Fgl2抑制剂治疗和控制人乙型肝炎病毒诱导的肝炎的进展。 Fgl2的抑制剂包括Fgl2的抗体。
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