公开(公告)号：US08563912B2

公开(公告)日：2013-10-22

申请号：US12937970

申请日：2009-04-04

申请人： Reiner Mitzkus ,  Eugen Wehner ,  Stefan Steinborn ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

发明人： Reiner Mitzkus ,  Eugen Wehner ,  Stefan Steinborn ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

IPC分类号： G02B27/40

CPC分类号： G02B21/241

摘要： The invention relates to a microscope having a stage for supporting a sample to be examined, a recording sensor, an imaging optic for imaging the sample onto the recording sensor, a moving unit by means of which the distance between the stage and the imaging optic can be changed, a control unit for controlling an image recording of the sample and a focus-holding unit for maintaining a prescribed focal position for image recording of the sample at temporal intervals, wherein the focus-holding device comprises at least one hardware element and one software module, wherein the focus-holding unit is fully integrated in the control unit, on both the hardware and software sides.

摘要翻译： 本发明涉及一种显微镜，其具有用于支撑待检查样本的台，记录传感器，用于将样本成像到记录传感器上的成像光学元件，移动单元，通过该移动单元，台与成像光学元件之间的距离 改变控制单元，用于控制样本的图像记录;以及聚焦保持单元，用于维持用于以时间间隔对样本进行图像记录的规定焦点位置，其中聚焦保持装置包括至少一个硬件元件和一个 软件模块，其中聚焦保持单元在硬件和软件两侧完全集成在控制单元中。

公开(公告)号：US20110043905A1

公开(公告)日：2011-02-24

申请号：US12937970

申请日：2009-04-04

申请人： Reiner Mitzkus ,  Eugen Wehner ,  Stefan Steinborn ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

发明人： Reiner Mitzkus ,  Eugen Wehner ,  Stefan Steinborn ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

IPC分类号： G02B21/24

CPC分类号： G02B21/241

摘要： The invention relates to a microscope having a stage for supporting a sample to be examined, a recording sensor, an imaging optic for imaging the sample onto the recording sensor, a moving unit by means of which the distance between the stage and the imaging optic can be changed, a control unit for controlling an image recording of the sample and a focus-holding unit for maintaining a prescribed focal position for image recording of the sample at temporal intervals, wherein the focus-holding device comprises at least one hardware element and one software module, wherein the focus-holding unit is fully integrated in the control unit, on both the hardware and software sides.

摘要翻译： 本发明涉及一种显微镜，其具有用于支撑待检查样本的台，记录传感器，用于将样本成像到记录传感器上的成像光学元件，移动单元，通过该移动单元，台与成像光学元件之间的距离 改变控制单元，用于控制样本的图像记录;以及聚焦保持单元，用于维持用于以时间间隔对样本进行图像记录的规定焦点位置，其中聚焦保持装置包括至少一个硬件元件和一个 软件模块，其中聚焦保持单元在硬件和软件两侧完全集成在控制单元中。

公开(公告)号：US09128296B2

公开(公告)日：2015-09-08

申请号：US12937965

申请日：2009-04-04

申请人： Stefan Steinborn ,  Eugen Wehner ,  Reiner Mitzkus ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

发明人： Stefan Steinborn ,  Eugen Wehner ,  Reiner Mitzkus ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

IPC分类号： G02B27/64 ,  G02B21/24 ,  G03B13/34 ,  G01B11/22 ,  G03B13/32 ,  G01B11/28 ,  G06K9/00 ,  G05B11/12 ,  G05B11/06 ,  G05B11/10 ,  G03B13/36 ,  G02B21/36

CPC分类号： G02B21/241 ,  G01B11/22 ,  G01B11/28 ,  G01B11/285 ,  G02B21/367 ,  G03B13/32 ,  G03B13/34 ,  G03B13/36 ,  G05B11/06 ,  G05B11/10 ,  G05B11/12 ,  G06K9/00127

摘要： A microscope including an imaging optical unit, a sample stage for supporting a sample to be examined, a movement unit, by which the distance between sample stage and imaging optical unit can be altered, a focus measuring unit, which measures the present focus position and outputs a focus measurement signal, a control unit for maintaining a predetermined focus position for examinations of the sample that are separated from one another in time. The control unit receives the focus measurement signal and derives a deviation of the present focus position from the predetermined focus position. Dependent on the deviation derived the movement unit, changes the distance between sample stage and imaging optical unit so that the predetermined focus position is maintained. The control unit drives the movement unit (9) for maintaining the predetermined focus position only before and/or after at least one of the examinations, but never during the examinations.

摘要翻译： 显微镜，包括成像光学单元，用于支撑待检测样品的样品台，可以改变样品台和成像光学单元之间的距离的移动单元，测量当前聚焦位置的聚焦测量单元， 输出焦点测量信号，用于维持用于在时间上彼此分离的样本的检查的预定焦点位置的控制单元。 控制单元接收聚焦测量信号并且导出当前聚焦位置与预定聚焦位置的偏差。 取决于移动单元的偏差，改变样本台与成像光学单元之间的距离，从而保持预定的对焦位置。 控制单元驱动运动单元（9），用于仅在检查中的至少一个之前和/或之后维持预定的对焦位置，但从不在检查期间。

公开(公告)号：US20110051232A1

公开(公告)日：2011-03-03

申请号：US12937965

申请日：2009-04-04

申请人： Stefan Steinborn ,  Eugen Wehner ,  Reiner Mitzkus ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

发明人： Stefan Steinborn ,  Eugen Wehner ,  Reiner Mitzkus ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

IPC分类号： G02B21/26 ,  G02B21/00

CPC分类号： G02B21/241 ,  G01B11/22 ,  G01B11/28 ,  G01B11/285 ,  G02B21/367 ,  G03B13/32 ,  G03B13/34 ,  G03B13/36 ,  G05B11/06 ,  G05B11/10 ,  G05B11/12 ,  G06K9/00127

摘要： A microscope including an imaging optical unit, a sample stage for supporting a sample to be examined, a movement unit, by which the distance between sample stage and imaging optical unit can be altered, a focus measuring unit, which measures the present focus position and outputs a focus measurement signal, a control unit for maintaining a predetermined focus position for examinations of the sample that are separated from one another in time. The control unit receives the focus measurement signal and derives a deviation of the present focus position from the predetermined focus position. Dependent on the deviation derived the movement unit, changes the distance between sample stage and imaging optical unit so that the predetermined focus position is maintained. The control unit drives the movement unit (9) for maintaining the predetermined focus position only before and/or after at least one of the examinations, but never during the examinations.

摘要翻译： 显微镜，包括成像光学单元，用于支撑待检测样品的样品台，可以改变样品台和成像光学单元之间的距离的移动单元，测量当前聚焦位置的聚焦测量单元， 输出焦点测量信号，用于维持用于在时间上彼此分离的样本的检查的预定焦点位置的控制单元。 控制单元接收聚焦测量信号并且导出当前聚焦位置与预定聚焦位置的偏差。 取决于移动单元的偏差，改变样本台与成像光学单元之间的距离，从而保持预定的对焦位置。 控制单元驱动运动单元（9），用于仅在检查中的至少一个之前和/或之后维持预定的对焦位置，但从不在检查期间。

公开(公告)号：US07502165B2

公开(公告)日：2009-03-10

申请号：US11828617

申请日：2007-07-26

申请人： Eugen Wehner ,  Joerg Schaffer ,  Werner Kleinschmidt

发明人： Eugen Wehner ,  Joerg Schaffer ,  Werner Kleinschmidt

IPC分类号： G02B21/26

CPC分类号： G02B21/28 ,  B01L7/00 ,  G02B21/30

摘要： The invention is directed to an arrangement for regulating the temperature of the sample space of a microscope, preferably for observing cells (live cell imaging) with an objective turret carrying objectives, a sample holder serving to receive a sample, a heating or cooling insert with an incubator hood for managing the temperature of the sample holder, and an objective heating element or objective cooling element. According to the invention, at least one structural component part which blocks the heating flow or cooling flow is provided between the objective heating element or objective cooling element and the objective turret.

摘要翻译： 本发明涉及一种用于调节显微镜样品空间温度的装置，优选用于观察携带物镜的目标转盘（活细胞成像），用于接收样品的样品架，加热或冷却插入物 用于管理样品保持器的温度的孵化器罩，以及客观加热元件或目标冷却元件。 根据本发明，在目标加热元件或目标冷却元件和物镜转台之间设置有阻挡加热流或冷却流的至少一个结构部件。

公开(公告)号：US20080071407A1

公开(公告)日：2008-03-20

申请号：US11857866

申请日：2007-09-19

申请人： Jorg Schaffer ,  Eugen Wehner

发明人： Jorg Schaffer ,  Eugen Wehner

IPC分类号： G06F19/00

CPC分类号： G02B21/365 ,  G02B21/24

摘要： A microscope configuration according to an exemplary embodiment includes a microscope system with at least one addressable component and also a control system with a plurality of control modules for influencing a plurality of test-environment parameters in a test chamber of the microscope system. The control modules are configured to be combined in modular manner and to be coupled through an interface unit with a unified bus, through which they are controlled. A control module influencing a test-environment parameter of an incubation system has a control command interface unit configured to receive at least one control command. The control command interface unit couples with a bus. A control device is coupled with the control command interface unit and influences the test-environment parameter based upon the control command. A further interface unit is coupled to the control command interface unit and outputs, again, the received control command.

摘要翻译： 根据示例性实施例的显微镜配置包括具有至少一个可寻址部件的显微镜系统，以及具有用于影响显微镜系统的测试室中的多个测试环境参数的多个控制模块的控制系统。 控制模块被配置为以模块化方式组合并且通过与统一总线的接口单元耦合，通过它们被控制。 影响孵化系统的测试环境参数的控制模块具有被配置为接收至少一个控制命令的控制命令接口单元。 控制命令接口单元与总线耦合。 控制装置与控制命令接口单元耦合，并根据控制命令影响测试环境参数。 另一个接口单元耦合到控制命令接口单元，并再次输出接收到的控制命令。

公开(公告)号：US08249727B2

公开(公告)日：2012-08-21

申请号：US11857866

申请日：2007-09-19

申请人： Jörg Schaffer ,  Eugen Wehner

发明人： Jörg Schaffer ,  Eugen Wehner

IPC分类号： G06F19/00

CPC分类号： G02B21/365 ,  G02B21/24

摘要： A microscope configuration according to an exemplary embodiment includes a microscope system with at least one addressable component and also a control system with a plurality of control modules for influencing a plurality of test-environment parameters in a test chamber of the microscope system. The control modules are configured to be combined in modular manner and to be coupled through an interface unit with a unified bus, through which they are controlled. A control module influencing a test-environment parameter of an incubation system has a control command interface unit configured to receive at least one control command. The control command interface unit couples with a bus. A control device is coupled with the control command interface unit and influences the test-environment parameter based upon the control command. A further interface unit is coupled to the control command interface unit and outputs, again, the received control command.

摘要翻译： 根据示例性实施例的显微镜配置包括具有至少一个可寻址部件的显微镜系统，以及具有用于影响显微镜系统的测试室中的多个测试环境参数的多个控制模块的控制系统。 控制模块被配置为以模块化方式组合并且通过与统一总线的接口单元耦合，通过它们被控制。 影响孵化系统的测试环境参数的控制模块具有被配置为接收至少一个控制命令的控制命令接口单元。 控制命令接口单元与总线耦合。 控制装置与控制命令接口单元耦合，并根据控制命令影响测试环境参数。 另一个接口单元耦合到控制命令接口单元，并再次输出接收到的控制命令。