公开(公告)号：US09128296B2

公开(公告)日：2015-09-08

申请号：US12937965

申请日：2009-04-04

申请人： Stefan Steinborn ,  Eugen Wehner ,  Reiner Mitzkus ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

发明人： Stefan Steinborn ,  Eugen Wehner ,  Reiner Mitzkus ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

IPC分类号： G02B27/64 ,  G02B21/24 ,  G03B13/34 ,  G01B11/22 ,  G03B13/32 ,  G01B11/28 ,  G06K9/00 ,  G05B11/12 ,  G05B11/06 ,  G05B11/10 ,  G03B13/36 ,  G02B21/36

CPC分类号： G02B21/241 ,  G01B11/22 ,  G01B11/28 ,  G01B11/285 ,  G02B21/367 ,  G03B13/32 ,  G03B13/34 ,  G03B13/36 ,  G05B11/06 ,  G05B11/10 ,  G05B11/12 ,  G06K9/00127

摘要： A microscope including an imaging optical unit, a sample stage for supporting a sample to be examined, a movement unit, by which the distance between sample stage and imaging optical unit can be altered, a focus measuring unit, which measures the present focus position and outputs a focus measurement signal, a control unit for maintaining a predetermined focus position for examinations of the sample that are separated from one another in time. The control unit receives the focus measurement signal and derives a deviation of the present focus position from the predetermined focus position. Dependent on the deviation derived the movement unit, changes the distance between sample stage and imaging optical unit so that the predetermined focus position is maintained. The control unit drives the movement unit (9) for maintaining the predetermined focus position only before and/or after at least one of the examinations, but never during the examinations.

摘要翻译： 显微镜，包括成像光学单元，用于支撑待检测样品的样品台，可以改变样品台和成像光学单元之间的距离的移动单元，测量当前聚焦位置的聚焦测量单元， 输出焦点测量信号，用于维持用于在时间上彼此分离的样本的检查的预定焦点位置的控制单元。 控制单元接收聚焦测量信号并且导出当前聚焦位置与预定聚焦位置的偏差。 取决于移动单元的偏差，改变样本台与成像光学单元之间的距离，从而保持预定的对焦位置。 控制单元驱动运动单元（9），用于仅在检查中的至少一个之前和/或之后维持预定的对焦位置，但从不在检查期间。

公开(公告)号：US20110051232A1

公开(公告)日：2011-03-03

申请号：US12937965

申请日：2009-04-04

申请人： Stefan Steinborn ,  Eugen Wehner ,  Reiner Mitzkus ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

发明人： Stefan Steinborn ,  Eugen Wehner ,  Reiner Mitzkus ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

IPC分类号： G02B21/26 ,  G02B21/00

CPC分类号： G02B21/241 ,  G01B11/22 ,  G01B11/28 ,  G01B11/285 ,  G02B21/367 ,  G03B13/32 ,  G03B13/34 ,  G03B13/36 ,  G05B11/06 ,  G05B11/10 ,  G05B11/12 ,  G06K9/00127

摘要： A microscope including an imaging optical unit, a sample stage for supporting a sample to be examined, a movement unit, by which the distance between sample stage and imaging optical unit can be altered, a focus measuring unit, which measures the present focus position and outputs a focus measurement signal, a control unit for maintaining a predetermined focus position for examinations of the sample that are separated from one another in time. The control unit receives the focus measurement signal and derives a deviation of the present focus position from the predetermined focus position. Dependent on the deviation derived the movement unit, changes the distance between sample stage and imaging optical unit so that the predetermined focus position is maintained. The control unit drives the movement unit (9) for maintaining the predetermined focus position only before and/or after at least one of the examinations, but never during the examinations.

摘要翻译： 显微镜，包括成像光学单元，用于支撑待检测样品的样品台，可以改变样品台和成像光学单元之间的距离的移动单元，测量当前聚焦位置的聚焦测量单元， 输出焦点测量信号，用于维持用于在时间上彼此分离的样本的检查的预定焦点位置的控制单元。 控制单元接收聚焦测量信号并且导出当前聚焦位置与预定聚焦位置的偏差。 取决于移动单元的偏差，改变样本台与成像光学单元之间的距离，从而保持预定的对焦位置。 控制单元驱动运动单元（9），用于仅在检查中的至少一个之前和/或之后维持预定的对焦位置，但从不在检查期间。

公开(公告)号：US08563912B2

公开(公告)日：2013-10-22

申请号：US12937970

申请日：2009-04-04

申请人： Reiner Mitzkus ,  Eugen Wehner ,  Stefan Steinborn ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

发明人： Reiner Mitzkus ,  Eugen Wehner ,  Stefan Steinborn ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

IPC分类号： G02B27/40

CPC分类号： G02B21/241

摘要： The invention relates to a microscope having a stage for supporting a sample to be examined, a recording sensor, an imaging optic for imaging the sample onto the recording sensor, a moving unit by means of which the distance between the stage and the imaging optic can be changed, a control unit for controlling an image recording of the sample and a focus-holding unit for maintaining a prescribed focal position for image recording of the sample at temporal intervals, wherein the focus-holding device comprises at least one hardware element and one software module, wherein the focus-holding unit is fully integrated in the control unit, on both the hardware and software sides.

摘要翻译： 本发明涉及一种显微镜，其具有用于支撑待检查样本的台，记录传感器，用于将样本成像到记录传感器上的成像光学元件，移动单元，通过该移动单元，台与成像光学元件之间的距离 改变控制单元，用于控制样本的图像记录;以及聚焦保持单元，用于维持用于以时间间隔对样本进行图像记录的规定焦点位置，其中聚焦保持装置包括至少一个硬件元件和一个 软件模块，其中聚焦保持单元在硬件和软件两侧完全集成在控制单元中。

公开(公告)号：US20110043905A1

公开(公告)日：2011-02-24

申请号：US12937970

申请日：2009-04-04

申请人： Reiner Mitzkus ,  Eugen Wehner ,  Stefan Steinborn ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

发明人： Reiner Mitzkus ,  Eugen Wehner ,  Stefan Steinborn ,  Gleb Milinovici ,  Steffen Leidenbach ,  Peter Westphal

IPC分类号： G02B21/24

CPC分类号： G02B21/241

摘要： The invention relates to a microscope having a stage for supporting a sample to be examined, a recording sensor, an imaging optic for imaging the sample onto the recording sensor, a moving unit by means of which the distance between the stage and the imaging optic can be changed, a control unit for controlling an image recording of the sample and a focus-holding unit for maintaining a prescribed focal position for image recording of the sample at temporal intervals, wherein the focus-holding device comprises at least one hardware element and one software module, wherein the focus-holding unit is fully integrated in the control unit, on both the hardware and software sides.

摘要翻译： 本发明涉及一种显微镜，其具有用于支撑待检查样本的台，记录传感器，用于将样本成像到记录传感器上的成像光学元件，移动单元，通过该移动单元，台与成像光学元件之间的距离 改变控制单元，用于控制样本的图像记录;以及聚焦保持单元，用于维持用于以时间间隔对样本进行图像记录的规定焦点位置，其中聚焦保持装置包括至少一个硬件元件和一个 软件模块，其中聚焦保持单元在硬件和软件两侧完全集成在控制单元中。

公开(公告)号：US20070024962A1

公开(公告)日：2007-02-01

申请号：US11457194

申请日：2006-07-13

申请人： STEFAN STEINBORN ,  Steffen Leidenbach

发明人： STEFAN STEINBORN ,  Steffen Leidenbach

IPC分类号： G02B21/00

CPC分类号： G02B21/365

摘要： In a method for determining configuration-dependent and state-dependent microscope parameters which are influenced by a plurality of microscope components that are arranged in the optical path of a microscope, it is the object of the invention to design the quantification method for the microscope parameters in a universally usable manner, i.e., so as to be applicable in an improved manner for microscopes of different constructions. After preparing a microscope-specific tree structure of the optical paths which proceeds from an object to be observed and extends from the start of the illumination beam paths to the end of the observation beam paths, the positions of the microscope components in the tree structure and components preceding and succeeding each of the microscope components are determined. Proceeding from a starting point in the tree structure, the degree of influence exerted on the microscope parameter to be determined is determined recursively along a chain of preceding components or succeeding components as a partial contribution for each microscope component exerting an influence in order to determine from the partial contributions the total influence exerted on the microscope parameter by the microscope components.

摘要翻译： 在用于确定配置在显微镜的光路中的多个显微镜部件影响的配置依赖性和状态依赖性显微镜参数的方法中，本发明的目的是设计显微镜参数的量化方法 以普遍可用的方式，即，以对于不同结构的显微镜的改进的方式适用。 在准备从待观察物体前进并且从照明光束路径的开始延伸到观察光束路径的末端的光路的显微镜特定树结构时，树结构中的显微镜部件的位置和 确定每个显微镜部件之前和之后的部件。 从树结构的出发点开始，对要确定的显微镜参数的影响程度沿着前面的部件或后续部件的链递归地确定，作为对每个显微镜部件施加影响的部分贡献，以便从 通过显微镜组件对显微镜参数的总影响的部分贡献。