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公开(公告)号：US20090314666A1
公开(公告)日：2009-12-24
申请号：US12226082
申请日：2007-04-12
IPC分类号： B65D25/00
CPC分类号： B01F15/0085 , B01F7/16 , B01F11/04 , B01F13/08 , B01F15/00896 , B01F2215/0032
摘要： Container system with one container (1) with a flexible partition, in particular a disposable container, that can be inserted into a carrying container that supports its lateral container partition (10) and in which liquid medium (8) that has been poured in can be mixed, with the carrying container (4) featuring at least one baffle (15, 15′, 15″, 15′″) on the internal support partition (11) that forms the lateral container partition.
摘要翻译： 具有一个容器（1）的容器系统，其具有柔性分隔物，特别是一次性容器，其可以插入到支撑其侧向容器隔板（10）的运载容器中，并且其中已经注入罐的液体介质（8） 与在内部支撑隔板（11）上具有至少一个挡板（15,15'，15“，15”）的承载容器（4）混合，形成侧向容器隔板。
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公开(公告)号：US20090263848A1
公开(公告)日：2009-10-22
申请号：US12227186
申请日：2007-04-24
申请人： Stefan Obermann , Reinhard Baumfalk , Oscar-Werner Reif , Florian Wurm , Maria De Jesus , Matthieu Stettler , Martin Jordan
发明人： Stefan Obermann , Reinhard Baumfalk , Oscar-Werner Reif , Florian Wurm , Maria De Jesus , Matthieu Stettler , Martin Jordan
IPC分类号： C12Q1/02
CPC分类号： G01N33/58 , G01N1/30 , G01N15/042 , G01N33/5005 , Y10T436/25375
摘要： The invention relates to a method for determining the viability of cells in cell cultures, said method comprising the steps of: colouring the sample with a dye which can penetrate into individual cells depending on the viability of the latter, determining the proportions of cells which are coloured to differing extents. The invention is distinguished by virtue of the fact that a cell suspension of the coloured cells is centrifuged as a sample in a sample vessel (10) until the solid content present in the sample has settled as a compressed cell cake (13), and, in order to determine the proportions, the volumes of differently coloured sections (131, 132, 133) of the compressed cell cake (13) are determined as a measure of the proportions of cells of different viability.
摘要翻译： 本发明涉及一种用于确定细胞培养物中细胞存活率的方法，所述方法包括以下步骤：根据染色体的活力来染色样品，所述染料可渗透到单个细胞中，确定细胞的比例 彩色到不同的程度。 本发明的区别在于，将着色细胞的细胞悬浮液作为样品在样品容器（10）中离心直到样品中存在的固体含量作为压缩细胞饼（13）沉降， 为了确定比例，压缩细胞饼（13）的不同颜色的部分（131,132,133）的体积被确定为不同存活力的细胞比例的量度。
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公开(公告)号：US20090075362A1
公开(公告)日：2009-03-19
申请号：US12226463
申请日：2007-04-24
申请人： Reinhard Baumfalk , Oscar-Werner Reif , Thomas Scheper , Daniel Riechers , Russell Hayden , Philip Nuzzo
发明人： Reinhard Baumfalk , Oscar-Werner Reif , Thomas Scheper , Daniel Riechers , Russell Hayden , Philip Nuzzo
IPC分类号： C12M3/00
CPC分类号： C12M23/28 , B01L3/505 , B01L2200/026 , B01L2200/04 , B01L2300/0627 , B01L2300/0645 , B01L2300/0654 , C12M23/00 , C12M23/14 , C12M41/00
摘要： The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.
摘要翻译： 本发明涉及一种一次性生物反应器，其包括用于测量所容纳介质的物理变量的可逆的外部可附接的传感器装置。 一种传感器适配器（28），用于接收与所述介质相互作用的电子传感器装置（34,38; 42; 44a，44b，46,48），所述电子传感器装置通过内部 所述传感器适配器的限定表面（32a，32b; 42; 44a，44b，46,48）被整合到所述生物反应器的至少一个外围线路（14,16,18）中，所述外围线路用于提供或释放 中。 所述传感器适配器（28）作为插入件延伸外围线路（14,16,18）而安装在外围线路（14,16,18）上，并可由所容纳的介质交叉流动。
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公开(公告)号：US10322388B2
公开(公告)日：2019-06-18
申请号：US12226082
申请日：2007-04-12
摘要： Container system with one container (1) with a flexible partition, in particular a disposable container, that can be inserted into a carrying container that supports its lateral container partition (10) and in which liquid medium (8) that has been poured in can be mixed, with the carrying container (4) featuring at least one baffle (15, 15′, 15″, 15′″) on the internal support partition (11) that forms the lateral container partition.
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公开(公告)号：US08580199B2
公开(公告)日：2013-11-12
申请号：US11651823
申请日：2007-01-10
CPC分类号： G01N21/274 , G01N21/0332 , G01N21/7703 , G01N2021/7786
摘要： A sensor for measuring an oxygen content in a liquid or gaseous sample has first and second sensor sections (14a, 14b). The first sensor section (14a) can be brought into contact with the sample and has a luminescent indicator dye embedded in an oxygen-permeable first polymer matrix. The second sensor section (14b) is arranged adjacent to the first sensor section (14a) and includes the same dye embedded in an oxygen-impermeable second polymer matrix. A light guide (10) guides luminescence excitation light from a light source (31, 32) to the sensor sections (14a, 14b) and guides luminescence emission light from the sensor section (14a, 14b) to a detector (39).
摘要翻译： 用于测量液体或气体样品中的氧含量的传感器具有第一和第二传感器部分（14a，14b）。 第一传感器部分（14a）可以与样品接触，并且具有嵌入氧气可渗透的第一聚合物基质中的发光指示剂染料。 第二传感器部分（14b）布置成与第一传感器部分（14a）相邻并且包括嵌入在不透氧的第二聚合物基质中的相同的染料。 光导（10）将来自光源（31,32）的发光激发光引导到传感器部分（14a，14b），并将来自传感器部分（14a，14b）的发光发射光引导到检测器（39）。
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公开(公告)号：US07924169B2
公开(公告)日：2011-04-12
申请号：US12584639
申请日：2009-09-09
CPC分类号： G01D11/30 , B01F15/00831 , B01F15/0085
摘要： Device for fastening a sensor on containers with a flexible container wall, in particular mixing bags, comprising a sensor support which is fitted with a sensor, bears against an inner wall of the container wall at least with a rear subsurface averted from the sensor, and is guided with a central piece through an opening in the container wall in which the sensor support is fixed on the container wall by a clamping part which can be connected to the central piece, in which the container wall is clamped between the rear subsurface of the sensor support and on a bearing surface, facing an outer wall of the container, of the clamping part, and in which the rear subsurface bears sealingly against the inner wall of the container wall. The sensor support can also have an electronic or optical transmit unit which is connected to the sensor, in which case the transmit unit communicates in a wireless fashion with a receive unit arranged outside the container.
摘要翻译： 用于将具有柔性容器壁的特定混合袋固定在容器上的装置，特别是混合袋，其包括安装有传感器的传感器支撑件，至少与从传感器避开的后表面相对地抵靠容器壁的内壁;以及 由中心件引导通过容器壁中的开口，其中传感器支撑件通过夹持部分固定在容器壁上，该夹紧部分可连接到中心件，容器壁夹在中间件的后表面之间 传感器支撑件以及位于容器的外壁上的支承表面上的夹紧部分，并且后部表面在其中密封地抵靠容器壁的内壁。 传感器支撑件还可以具有连接到传感器的电子或光学发射单元，在这种情况下，发射单元以布置在容器外部的接收单元以无线方式通信。
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公开(公告)号：US07603921B2
公开(公告)日：2009-10-20
申请号：US11642264
申请日：2006-12-20
IPC分类号： G01M19/00
CPC分类号： G01D11/30 , B01F15/00831 , B01F15/0085
摘要： Device for fastening a sensor on containers with a flexible container wall, in particular mixing bags, comprising a sensor support which is fitted with a sensor, bears against an inner wall of the container wall at least with a rear subsurface averted from the sensor, and is guided with a central piece through an opening in the container wall in which the sensor support is fixed on the container wall by a clamping part which can be connected to the central piece, in which the container wall is clamped between the rear subsurface of the sensor support and on a bearing surface, facing an outer wall of the container, of the clamping part, and in which the rear subsurface bears sealingly against the inner wall of the container wall. The sensor support can also have an electronic or optical transmit unit which is connected to the sensor, in which case the transmit unit communicates in a wireless fashion with a receive unit arranged outside the container.
摘要翻译： 用于将具有柔性容器壁的特定混合袋固定在容器上的装置，特别是混合袋，其包括安装有传感器的传感器支撑件，至少与从传感器避开的后表面相对地抵靠容器壁的内壁;以及 由中心件引导通过容器壁中的开口，其中传感器支撑件通过夹持部分固定在容器壁上，该夹紧部分可连接到中心件，容器壁夹在中间件的后表面之间 传感器支撑件以及位于容器的外壁上的支承表面上的夹紧部分，并且后部表面在其中密封地抵靠容器壁的内壁。 传感器支撑件还可以具有连接到传感器的电子或光学发射单元，在这种情况下，发射单元以布置在容器外部的接收单元以无线方式通信。
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8.发明授权Cleaning method for filter testing device, computer program product for implementing said method and filter testing device 有权过滤器检测装置的清洗方法，实现所述方法和过滤器检测装置的计算机程序产品公开(公告)号：US07198053B2
公开(公告)日：2007-04-03
申请号：US10762553
申请日：2004-01-23
IPC分类号： B08B3/00
CPC分类号： B01D46/46 , B01D2273/18
摘要： A cleaning method for a filter testing device (10) including switching devices (V1–V6), external connections (12, 14, 16, 18, 20) and internal volumes (24, 26, 28, 30, VV1–VV5) that can come into contact with a fluid from a filter device that is to be tested. The cleaning method involves the steps of: selecting one or more internal volumes (24, 26, 28, 30, VV1–VV5) to be cleaned, cleaning the selected internal volumes (24, 26, 28, 30, VV1–VV5) with a cleaning fluid by correspondingly switching the switching devices (V1–V6), and removing the cleaning fluid contained in the internal volumes (24, 26, 28, 30, VV1–VV5) from the internal volumes. Also a computer program product with program parts for implementing the method of the invention or a preferred embodiment thereof, and a filter testing device adapted to be cleaned by the method of the invention.
摘要翻译： 一种用于包括开关装置（V 1 -V 6），外部连接（12,14,16,18,20）和内部容积（24,26,28,30，V
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9.发明授权Container having flexible walls with connecting piece for mixer shaft and coupling piece for drive device fixed magnetically to opposite inner and outer surfaces of container wall 有权容器具有柔性壁，其具有用于混合器轴的连接件和用于驱动装置的联接件，磁力固定到容器壁的相对的内表面和外表面公开(公告)号：US09095828B2
公开(公告)日：2015-08-04
申请号：US11717357
申请日：2007-03-13
CPC分类号： B01F13/0827 , B01F11/0082 , B01F11/0091 , B01F13/0863 , B01F15/0085 , B01F2215/0032
摘要： A container has flexible walls defining an interior. A mixer is arranged in the interior of the container and includes a mixer shaft with opposite first and second ends. A mixing element is mounted to the first end of the mixer shaft. The second end of the mixer shaft is fixed magnetically to a coupling piece disposed on the exterior of the flexible wall of the container. The coupling piece is connected operatively to a force introducing device that generates movement of the mixer.
摘要翻译： 容器具有限定内部的柔性壁。 混合器布置在容器的内部，并包括具有相对的第一和第二端的混合器轴。 混合元件安装到混合器轴的第一端。 混合器轴的第二端固定地固定在设置在容器的柔性壁的外部上的联接件上。 联接件可操作地连接到产生混合器运动的力导入装置。
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10.发明授权Device, method and computer programme product for carrying out integrity tests on filter elements 有权用于对过滤元件执行完整性测试的设备，方法和计算机程序产品公开(公告)号：US07360400B2
公开(公告)日：2008-04-22
申请号：US11446789
申请日：2006-06-05
IPC分类号： G01N15/08
CPC分类号： G01N15/0826 , B01D46/0086 , B01D2201/56 , B01D2273/18
摘要： The invention relates to a device for carrying out integrity tests on filter elements by means of test gases, comprising a device housing (3), with an electronic controller (4), arranged therein for regulation and control of the progress of a test programme for filter elements, a filter housing (6), for housing a filter element (2) under test, a pneumatic unit (5), connected to the controller (4) and the filter housing (6), in particular for the generation and measurement of gas pressures, an electronic memory unit (10), which may be connected to the filter element (2) under test and a communication unit (13′), connected to the controller (4), for the exchange of data between the controller (4) and the electronic memory element (10). The communication unit (13′) is preferably embodied as an antenna (14′) and the electronic memory element (10) as a transponder (11). In addition to the device a method for carrying out integrity tests and a computer programme product are also disclosed.
摘要翻译： 本发明涉及一种用于通过测试气体对过滤元件执行完整性测试的装置，包括设置有用于调节和控制测试程序进度的装置壳体（3），其中安装有电子控制器（4） 过滤器元件，用于容纳被测试的过滤元件（2）的过滤器壳体（6），连接到控制器（4）和过滤器壳体（6）的气动单元（5），特别是用于产生和测量 的气体压力的电子存储器单元（10），可连接到被测试的过滤元件（2）的电子存储器单元（10）和连接到控制器（4）的通信单元（13'），用于在控制器 （4）和电子存储元件（10）。 通信单元（13'）优选地被实施为天线（14'）和作为应答器（11）的电子存储元件（10）。 此外，还公开了用于执行完整性测试的方法和计算机程序产品。
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