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公开(公告)号：US08580199B2
公开(公告)日：2013-11-12
申请号：US11651823
申请日：2007-01-10
CPC分类号： G01N21/274 , G01N21/0332 , G01N21/7703 , G01N2021/7786
摘要： A sensor for measuring an oxygen content in a liquid or gaseous sample has first and second sensor sections (14a, 14b). The first sensor section (14a) can be brought into contact with the sample and has a luminescent indicator dye embedded in an oxygen-permeable first polymer matrix. The second sensor section (14b) is arranged adjacent to the first sensor section (14a) and includes the same dye embedded in an oxygen-impermeable second polymer matrix. A light guide (10) guides luminescence excitation light from a light source (31, 32) to the sensor sections (14a, 14b) and guides luminescence emission light from the sensor section (14a, 14b) to a detector (39).
摘要翻译： 用于测量液体或气体样品中的氧含量的传感器具有第一和第二传感器部分（14a，14b）。 第一传感器部分（14a）可以与样品接触，并且具有嵌入氧气可渗透的第一聚合物基质中的发光指示剂染料。 第二传感器部分（14b）布置成与第一传感器部分（14a）相邻并且包括嵌入在不透氧的第二聚合物基质中的相同的染料。 光导（10）将来自光源（31,32）的发光激发光引导到传感器部分（14a，14b），并将来自传感器部分（14a，14b）的发光发射光引导到检测器（39）。
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公开(公告)号：US20070160500A1
公开(公告)日：2007-07-12
申请号：US11651823
申请日：2007-01-10
IPC分类号： G01N21/64
CPC分类号： G01N21/274 , G01N21/0332 , G01N21/7703 , G01N2021/7786
摘要： The invention relates to a sensor for measuring an oxygen content in a liquid or gaseous sample, comprising a first sensor section (14a) that can be brought into contact with the sample and has a luminescent indicator dye embedded in an oxygen-permeable, first polymer matrix, light guiding means (10) for guiding luminescence excitation light from a light source (31, 32) to the first sensor section (14a), and light guiding means (10) for guiding luminescence emission light from the first sensor section (14a) to a detector (39). The invention is distinguished in that arranged adjacent to the first sensor section (14a) is a second sensor section (14b) that includes the same dye, embedded in an oxygen-impermeable, second polymer matrix.
摘要翻译： 本发明涉及一种用于测量液体或气体样品中氧含量的传感器，包括可与样品接触的第一传感器部分（14a），并且具有嵌入氧气可渗透的第一传感器部分 聚合物基体，用于将来自光源（31,32）的发光激发光引导到第一传感器部分（14a）的导光装置（10），以及用于引导来自第一传感器部分的发光发射光的导光装置 （14a）到检测器（39）。 本发明的区别在于邻近第一传感器部分（14a）布置的是包含相同染料的第二传感器部分（14b），其嵌入在不透氧的第二聚合物基质中。
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公开(公告)号：US20090075362A1
公开(公告)日：2009-03-19
申请号：US12226463
申请日：2007-04-24
申请人： Reinhard Baumfalk , Oscar-Werner Reif , Thomas Scheper , Daniel Riechers , Russell Hayden , Philip Nuzzo
发明人： Reinhard Baumfalk , Oscar-Werner Reif , Thomas Scheper , Daniel Riechers , Russell Hayden , Philip Nuzzo
IPC分类号： C12M3/00
CPC分类号： C12M23/28 , B01L3/505 , B01L2200/026 , B01L2200/04 , B01L2300/0627 , B01L2300/0645 , B01L2300/0654 , C12M23/00 , C12M23/14 , C12M41/00
摘要： The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.
摘要翻译： 本发明涉及一种一次性生物反应器，其包括用于测量所容纳介质的物理变量的可逆的外部可附接的传感器装置。 一种传感器适配器（28），用于接收与所述介质相互作用的电子传感器装置（34,38; 42; 44a，44b，46,48），所述电子传感器装置通过内部 所述传感器适配器的限定表面（32a，32b; 42; 44a，44b，46,48）被整合到所述生物反应器的至少一个外围线路（14,16,18）中，所述外围线路用于提供或释放 中。 所述传感器适配器（28）作为插入件延伸外围线路（14,16,18）而安装在外围线路（14,16,18）上，并可由所容纳的介质交叉流动。
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公开(公告)号：US08252582B2
公开(公告)日：2012-08-28
申请号：US12226463
申请日：2007-04-24
申请人： Reinhard Baumfalk , Oscar-Werner Reif , Thomas Scheper , Daniel Riechers , Russell Hayden , Philip Nuzzo
发明人： Reinhard Baumfalk , Oscar-Werner Reif , Thomas Scheper , Daniel Riechers , Russell Hayden , Philip Nuzzo
CPC分类号： C12M23/28 , B01L3/505 , B01L2200/026 , B01L2200/04 , B01L2300/0627 , B01L2300/0645 , B01L2300/0654 , C12M23/00 , C12M23/14 , C12M41/00
摘要： The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.
摘要翻译： 本发明涉及一种一次性生物反应器，其包括用于测量所容纳介质的物理变量的可逆的外部可附接的传感器装置。 一种传感器适配器（28），用于接收与所述介质相互作用的电子传感器装置（34,38; 42; 44a，44b，46,48），所述电子传感器装置通过内部 所述传感器适配器的限定表面（32a，32b; 42; 44a，44b，46,48）被整合到所述生物反应器的至少一个外围线路（14,16,18）中，所述外围线路用于供应或排出 中。 所述传感器适配器（28）作为插入件延伸外围线路（14,16,18）而安装在外围线路（14,16,18）上，并可由所容纳的介质交叉流动。
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公开(公告)号：US06951613B2
公开(公告)日：2005-10-04
申请号：US10264491
申请日：2002-10-04
申请人： Oscar-Werner Reif , Thomas Scheper , Karl Friehs
发明人： Oscar-Werner Reif , Thomas Scheper , Karl Friehs
CPC分类号： A61M5/284
摘要： There is disclosed a genetic vaccination device and a process for forming an injection solution therefor, the device comprising a syringe and canula coupled to a membrane adsorber having genetic material adsorbed thereon, and the process comprising eluting the genetic material from the membrane adsorber so as to form an injection solution containing the genetic material.
摘要翻译： 公开了一种遗传接种装置及其注射溶液的形成方法，该装置包括与吸附有遗传物质的膜吸附器耦合的注射器和套管，该方法包括从膜吸附器洗脱遗传物质，以便 形成含有遗传物质的注射溶液。
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公开(公告)号：US20100035337A1
公开(公告)日：2010-02-11
申请号：US12460314
申请日：2009-07-16
IPC分类号： C12M3/00
摘要： Bioreactor having at least one transparent window (5, 12, 13), the inner side (6) of which can be touched by a medium that can be arranged in a reactor interior (3), wherein the window (5, 12, 13) has a photocatalytic coating (7) on its inner side (6) facing the reactor interior (3), which coating can be activated by at least one light source from the outer side remote from the inner side (6).
摘要翻译： 生物反应器具有至少一个透明窗口（5,12,13），其内侧（6）可以被可布置在反应器内部（3）中的介质所接触，其中窗口（5,12,13） ）在其内侧（6）上具有面向反应器内部（3）的光催化涂层（7），该涂层可以由远离内侧（6）的外侧的至少一个光源激活。
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7.发明申请MICROARRAY DEVICE FOR SCREENING OR LOCATING HSP90 INHIBITORS OR INHIBITORS OF FURTHER DISEASE-RELEVANT TARGET STRUCTURES 有权用于筛选或定位HSP90抑制剂或进一步疾病相关目标结构的抑制剂的微阵列装置公开(公告)号：US20140228235A1
公开(公告)日：2014-08-14
申请号：US14128298
申请日：2012-04-20
申请人： Dieter Melzner , Thomas Scheper , Thomas Schuler , Frank Stahl , Denise Van Rossum , Johanna-Gabriela Walter , Carsten Zeilinger
发明人： Dieter Melzner , Thomas Scheper , Thomas Schuler , Frank Stahl , Denise Van Rossum , Johanna-Gabriela Walter , Carsten Zeilinger
IPC分类号： G01N33/68
CPC分类号： G01N33/6845 , G01N33/6872
摘要： The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.
摘要翻译： 本发明涉及一种用于筛选或发现蛋白抑制剂的微阵列装置，涉及其制备方法，以及用于筛选或发现蛋白质抑制剂的相应方法。 根据本发明的微阵列装置包括固体支持元件，其具有支撑材料，至少一种固定在其上的用于筛选或发现抑制剂的蛋白质和至少一种已知的至少一种蛋白质的抑制剂，所述抑制剂被结合 至少一种蛋白质并包含可检测标记。
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公开(公告)号：US20090306346A1
公开(公告)日：2009-12-10
申请号：US12095784
申请日：2006-12-15
IPC分类号： C07K1/18
CPC分类号： C07K1/16 , B01D15/361 , B01J20/12 , B01J20/28057 , B01J20/28069 , B01J20/282
摘要： The invention relates to a method for separating proteins from liquid media, comprising providing a liquid medium containing proteins, providing a clay material which has: a specific surface greater than 150 m2/g, a pore volume greater than 0.35 ml/g, an ion exchange capacity greater than 40 meq/100 g, and a sediment volume in water of less than 15 ml/2 g, equilibrating said clay material to a pH of from 3.5 to 9.0, treating said liquid medium with the equilibrated clay material, and separating the purified, protein-depleted liquid medium from the clay material.
摘要翻译： 本发明涉及一种从液体培养基中分离蛋白质的方法，包括提供含有蛋白质的液体培养基，提供粘土材料，其具有大于150m 2 / g的比表面积，大于0.35ml / g的孔体积，离子 交换容量大于40meq / 100g，水中的沉淀物体积小于15ml / 2g，将所述粘土材料平衡至3.5至9.0的pH，用平衡的粘土材料处理所述液体介质，并分离 从粘土材料中纯化的，蛋白质贫乏的液体培养基。
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9.发明申请METHOD FOR THE SORPTION OF AT LEAST ONE NUCLEIC ACID-ACTIVATED PHYLLOSILICATES 审中-公开用于最少一个核酸活化的木质素的分离方法公开(公告)号：US20090221809A1
公开(公告)日：2009-09-03
申请号：US12096402
申请日：2005-12-09
CPC分类号： B01J20/12 , B01D15/08 , B01D15/362 , B01D15/424 , B01J20/10 , B01J20/28004 , B01J20/28016 , B01J20/2803 , B01J20/28033 , B01J20/28057 , B01J20/28069 , B01J20/28078
摘要： The invention relates to a method for the sorption of at least one nucleic acid molecule from a liquid medium, comprising the following steps: (a) providing a liquid medium comprising at least one nucleic acid molecule; (b) providing a layer comprising at least one acid-activated phyllosilicate, where the layer is permeable by the liquid medium, and the layer thickness is at least 1 mm; (c) passing the liquid medium with the at least one nucleic acid molecule from step (a) through the layer from step (b) for sorption of the at least one nucleic acid molecule in the layer.
摘要翻译： 本发明涉及一种从液体培养基中吸附至少一种核酸分子的方法，包括以下步骤：（a）提供包含至少一种核酸分子的液体培养基; （b）提供包含至少一种酸活化的页硅酸盐的层，其中所述层可被液体介质渗透，并且层厚度为至少1mm; （c）将来自步骤（a）的至少一种核酸分子的液体培养基通过来自步骤（b）的层，用于吸收该层中的至少一个核酸分子。
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公开(公告)号：US09891230B2
公开(公告)日：2018-02-13
申请号：US14128298
申请日：2012-04-20
申请人： Dieter Melzner , Thomas Scheper , Thomas Schueler , Frank Stahl , Denise Van Rossum , Johanna-Gabriela Walter , Carsten Zeilinger
发明人： Dieter Melzner , Thomas Scheper , Thomas Schueler , Frank Stahl , Denise Van Rossum , Johanna-Gabriela Walter , Carsten Zeilinger
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/6845 , G01N33/6872
摘要： The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.
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