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1.发明申请OPTICAL SENSOR COMPRISING A LAYER SOLUBLE IN THE MEDIUM TO BE MEASURED AND DEVICE COMPRISING IT, AND PROCESS FOR THEIR PRODUCTION 有权包含要测量的介质中的层可溶性的光学传感器及其包含的设备及其生产过程公开(公告)号：US20120132813A1
公开(公告)日：2012-05-31
申请号：US13389151
申请日：2010-07-10
CPC分类号： G01N21/645
摘要： An optical is provided with reduced sensitivity to radiation, more particularly gamma radiation. The optical sensor is suitable for determining at least one parameter in a medium and includes a matrix containing a fluorescent dye. The matrix is supported by a transparent support. On the side facing the medium, the matrix has a layer soluble in the medium, which layer provides protection against radiation or damaging radiation products. The optical sensor is suitable for implementation in containers and laboratory products, such as disposable bioreactors for example, which are sterilized using gamma radiation.
摘要翻译： 提供对辐射的敏感性降低，特别是γ辐射的光学。 光学传感器适用于确定介质中的至少一个参数，并且包括含有荧光染料的基质。 矩阵由透明支持支持。 在面向介质的一侧，基质具有可溶于介质的层，该层可以防止辐射或损害辐射产物。 光学传感器适用于容器和实验室产品，例如使用γ辐射灭菌的一次性生物反应器。
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2.发明申请SENSOR DEVICE, COMPRISING AN OPTICAL SENSOR, A CONTAINER AND A COMPARTMENTALIZATION MEANS 有权包含光学传感器，集装箱和货物装置的传感器装置公开(公告)号：US20120091326A1
公开(公告)日：2012-04-19
申请号：US13377845
申请日：2010-05-22
申请人： Reinhard Baumfalk , Stefan Weisshaar , Gerhard Greller , Daniel Riechers , Julia Lueders , Peter Pollossek
发明人： Reinhard Baumfalk , Stefan Weisshaar , Gerhard Greller , Daniel Riechers , Julia Lueders , Peter Pollossek
IPC分类号： H01J5/02
CPC分类号： A61L2/28 , A61L2/081 , G01N21/80 , G01N21/90 , G01N2021/7786
摘要： A sensor device has an optical sensor (1), a container (2) and a compartmentalizer (3) that temporarily divides the container into a main space (4) and an adjacent space (5), in which the optical sensor (1) is located. The gas volume in the direct vicinity of the optical sensor (1) is reduced, as are also, consequently, the reactive products generated by radiation sterilization. The adjacent space (5) can be united with the main space (4) after the sterilization as a result of the temporary compartmentalization. The optical sensor is suitable for implementation in containers and laboratory products, such as, for example, disposable bioreactors, that are sterilized by gamma radiation.
摘要翻译： 传感器装置具有光学传感器（1），容器（2）和分隔器（3），其将容器暂时分为主空间（4）和相邻的空间（5），其中光传感器（1） 位于。 直接靠近光学传感器（1）的气体体积减少，因此减少由辐射灭菌产生的反应性产物。 由于临时分隔，相邻的空间（5）可以在灭菌之后与主空间（4）结合。 光学传感器适用于容器和实验室产品，例如通过γ辐射灭菌的一次性生物反应器。
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公开(公告)号：US20110198255A1
公开(公告)日：2011-08-18
申请号：US13123912
申请日：2009-10-06
CPC分类号： A61J1/10 , A61J1/14 , A61J2200/72 , A61J2205/20 , A61J2205/60 , A61J2205/70 , B01L3/52 , B01L3/545 , B01L2200/143 , B01L2200/148 , B01L2300/022 , B01L2300/023 , B01L2300/024 , B01L2300/027 , G01N33/48785 , G01N35/00732 , G01N35/1002 , G01N2035/00633 , G01N2035/00673 , G01N2035/00851 , Y10T29/49826
摘要： A storage and/or reaction container system for fluids, includes a container and an electronic documentation device connected to the container. The documentation device further includes a timing device for capturing a point in time, at least one sensor, at least one input device for capturing inputs, and a storage device to store for readout at least one measured value captured by the at least one sensor device and/or an input captured by the at least one input device. The at least one measured value and/or the at least one input is associated by the timing device with the point in time of the capture.
摘要翻译： 用于流体的储存和/或反应容器系统包括连接到容器的容器和电子文件装置。 文档装置还包括用于捕获时间点的定时装置，至少一个传感器，用于捕获输入的至少一个输入装置，以及用于存储用于读出由至少一个传感器装置捕获的至少一个测量值的存储装置 和/或由至少一个输入设备捕获的输入。 所述至少一个测量值和/或所述至少一个输入由所述定时装置与所述捕获的时间点相关联。
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公开(公告)号：US20090314666A1
公开(公告)日：2009-12-24
申请号：US12226082
申请日：2007-04-12
IPC分类号： B65D25/00
CPC分类号： B01F15/0085 , B01F7/16 , B01F11/04 , B01F13/08 , B01F15/00896 , B01F2215/0032
摘要： Container system with one container (1) with a flexible partition, in particular a disposable container, that can be inserted into a carrying container that supports its lateral container partition (10) and in which liquid medium (8) that has been poured in can be mixed, with the carrying container (4) featuring at least one baffle (15, 15′, 15″, 15′″) on the internal support partition (11) that forms the lateral container partition.
摘要翻译： 具有一个容器（1）的容器系统，其具有柔性分隔物，特别是一次性容器，其可以插入到支撑其侧向容器隔板（10）的运载容器中，并且其中已经注入罐的液体介质（8） 与在内部支撑隔板（11）上具有至少一个挡板（15,15'，15“，15”）的承载容器（4）混合，形成侧向容器隔板。
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公开(公告)号：US20090263848A1
公开(公告)日：2009-10-22
申请号：US12227186
申请日：2007-04-24
申请人： Stefan Obermann , Reinhard Baumfalk , Oscar-Werner Reif , Florian Wurm , Maria De Jesus , Matthieu Stettler , Martin Jordan
发明人： Stefan Obermann , Reinhard Baumfalk , Oscar-Werner Reif , Florian Wurm , Maria De Jesus , Matthieu Stettler , Martin Jordan
IPC分类号： C12Q1/02
CPC分类号： G01N33/58 , G01N1/30 , G01N15/042 , G01N33/5005 , Y10T436/25375
摘要： The invention relates to a method for determining the viability of cells in cell cultures, said method comprising the steps of: colouring the sample with a dye which can penetrate into individual cells depending on the viability of the latter, determining the proportions of cells which are coloured to differing extents. The invention is distinguished by virtue of the fact that a cell suspension of the coloured cells is centrifuged as a sample in a sample vessel (10) until the solid content present in the sample has settled as a compressed cell cake (13), and, in order to determine the proportions, the volumes of differently coloured sections (131, 132, 133) of the compressed cell cake (13) are determined as a measure of the proportions of cells of different viability.
摘要翻译： 本发明涉及一种用于确定细胞培养物中细胞存活率的方法，所述方法包括以下步骤：根据染色体的活力来染色样品，所述染料可渗透到单个细胞中，确定细胞的比例 彩色到不同的程度。 本发明的区别在于，将着色细胞的细胞悬浮液作为样品在样品容器（10）中离心直到样品中存在的固体含量作为压缩细胞饼（13）沉降， 为了确定比例，压缩细胞饼（13）的不同颜色的部分（131,132,133）的体积被确定为不同存活力的细胞比例的量度。
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公开(公告)号：US20090075362A1
公开(公告)日：2009-03-19
申请号：US12226463
申请日：2007-04-24
申请人： Reinhard Baumfalk , Oscar-Werner Reif , Thomas Scheper , Daniel Riechers , Russell Hayden , Philip Nuzzo
发明人： Reinhard Baumfalk , Oscar-Werner Reif , Thomas Scheper , Daniel Riechers , Russell Hayden , Philip Nuzzo
IPC分类号： C12M3/00
CPC分类号： C12M23/28 , B01L3/505 , B01L2200/026 , B01L2200/04 , B01L2300/0627 , B01L2300/0645 , B01L2300/0654 , C12M23/00 , C12M23/14 , C12M41/00
摘要： The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.
摘要翻译： 本发明涉及一种一次性生物反应器，其包括用于测量所容纳介质的物理变量的可逆的外部可附接的传感器装置。 一种传感器适配器（28），用于接收与所述介质相互作用的电子传感器装置（34,38; 42; 44a，44b，46,48），所述电子传感器装置通过内部 所述传感器适配器的限定表面（32a，32b; 42; 44a，44b，46,48）被整合到所述生物反应器的至少一个外围线路（14,16,18）中，所述外围线路用于提供或释放 中。 所述传感器适配器（28）作为插入件延伸外围线路（14,16,18）而安装在外围线路（14,16,18）上，并可由所容纳的介质交叉流动。
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7.发明授权Container having flexible walls with connecting piece for mixer shaft and coupling piece for drive device fixed magnetically to opposite inner and outer surfaces of container wall 有权容器具有柔性壁，其具有用于混合器轴的连接件和用于驱动装置的联接件，磁力固定到容器壁的相对的内表面和外表面公开(公告)号：US09095828B2
公开(公告)日：2015-08-04
申请号：US11717357
申请日：2007-03-13
CPC分类号： B01F13/0827 , B01F11/0082 , B01F11/0091 , B01F13/0863 , B01F15/0085 , B01F2215/0032
摘要： A container has flexible walls defining an interior. A mixer is arranged in the interior of the container and includes a mixer shaft with opposite first and second ends. A mixing element is mounted to the first end of the mixer shaft. The second end of the mixer shaft is fixed magnetically to a coupling piece disposed on the exterior of the flexible wall of the container. The coupling piece is connected operatively to a force introducing device that generates movement of the mixer.
摘要翻译： 容器具有限定内部的柔性壁。 混合器布置在容器的内部，并包括具有相对的第一和第二端的混合器轴。 混合元件安装到混合器轴的第一端。 混合器轴的第二端固定地固定在设置在容器的柔性壁的外部上的联接件上。 联接件可操作地连接到产生混合器运动的力导入装置。
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公开(公告)号：US09095498B2
公开(公告)日：2015-08-04
申请号：US13123912
申请日：2009-10-06
CPC分类号： A61J1/10 , A61J1/14 , A61J2200/72 , A61J2205/20 , A61J2205/60 , A61J2205/70 , B01L3/52 , B01L3/545 , B01L2200/143 , B01L2200/148 , B01L2300/022 , B01L2300/023 , B01L2300/024 , B01L2300/027 , G01N33/48785 , G01N35/00732 , G01N35/1002 , G01N2035/00633 , G01N2035/00673 , G01N2035/00851 , Y10T29/49826
摘要： A storage and/or reaction container system for fluids, includes a container and an electronic documentation device connected to the container. The documentation device further includes a timing device for capturing a point in time, at least one sensor, at least one input device for capturing inputs, and a storage device to store for readout at least one measured value captured by the at least one sensor device and/or an input captured by the at least one input device. The at least one measured value and/or the at least one input is associated by the timing device with the point in time of the capture.
摘要翻译： 用于流体的储存和/或反应容器系统包括连接到容器的容器和电子文件装置。 文档装置还包括用于捕获时间点的定时装置，至少一个传感器，用于捕获输入的至少一个输入装置，以及用于存储用于读出由至少一个传感器装置捕获的至少一个测量值的存储装置 和/或由至少一个输入设备捕获的输入。 所述至少一个测量值和/或所述至少一个输入由所述定时装置与所述捕获的时间点相关联。
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9.发明授权Sensor device, comprising an optical sensor, a container and a compartmentalization means 有权传感器装置，包括光学传感器，容器和分隔装置公开(公告)号：US08859949B2
公开(公告)日：2014-10-14
申请号：US13377845
申请日：2010-05-22
申请人： Reinhard Baumfalk , Stefan Weisshaar , Gerhard Greller , Daniel Riechers , Julia Lueders , Peter Polossek
发明人： Reinhard Baumfalk , Stefan Weisshaar , Gerhard Greller , Daniel Riechers , Julia Lueders , Peter Polossek
CPC分类号： A61L2/28 , A61L2/081 , G01N21/80 , G01N21/90 , G01N2021/7786
摘要： A sensor device has an optical sensor (1), a container (2) and a compartmentalizer (3) that temporarily divides the container into a main space (4) and an adjacent space (5), in which the optical sensor (1) is located. The gas volume in the direct vicinity of the optical sensor (1) is reduced, as are also, consequently, the reactive products generated by radiation sterilization. The adjacent space (5) can be united with the main space (4) after the sterilization as a result of the temporary compartmentalization. The optical sensor is suitable for implementation in containers and laboratory products, such as, for example, disposable bioreactors, that are sterilized by gamma radiation.
摘要翻译： 传感器装置具有光学传感器（1），容器（2）和分隔器（3），其将容器暂时分为主空间（4）和相邻的空间（5），其中光传感器（1） 位于。 直接靠近光学传感器（1）的气体体积减少，因此减少由辐射灭菌产生的反应性产物。 由于临时分隔，相邻的空间（5）可以在灭菌之后与主空间（4）结合。 光学传感器适用于容器和实验室产品，例如通过γ辐射灭菌的一次性生物反应器。
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公开(公告)号：US08186870B2
公开(公告)日：2012-05-29
申请号：US11666210
申请日：2005-10-18
CPC分类号： B01F11/0014
摘要： The invention relates to a device for agitating media (1), which are located on a platform (3). Said device consists of a housing (2) with an agitation mechanism, which is used to agitate the platform (3) and at least one sensor (4, 5), which is connected to a control unit (7) that is equipped with an electronic sensor system (6). According to the invention, the sensor(s) (4, 5) and the electronic sensor system (6) are located on the platform (3) and communicate in a wireless manner with the fixed control unit (7).
摘要翻译： 本发明涉及一种用于搅拌位于平台（3）上的介质（1）的装置。 所述装置包括具有搅拌机构的壳体（2），所述壳体（2）用于搅拌所述平台（3）和至少一个传感器（4,5），所述传感器连接到控制单元（7），所述控制单元（7） 电子传感器系统（6）。 根据本发明，传感器（4,5）和电子传感器系统（6）位于平台（3）上，并以无线方式与固定控制单元（7）通信。
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