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公开(公告)号:US20170165292A1
公开(公告)日:2017-06-15
申请号:US15443664
申请日:2017-02-27
申请人: Relypsa, Inc.
发明人: Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Ramakrishnan Chidambaram , Jonathan Mills , Werner Strüver
IPC分类号: A61K31/78 , A61K47/26 , A61K9/14 , C08F220/22 , B01J39/20
CPC分类号: A61K31/78 , A61K9/14 , A61K31/7004 , A61K47/26 , B01J39/20 , C08F212/36 , C08F220/22
摘要: The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.
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公开(公告)号:US20130189216A1
公开(公告)日:2013-07-25
申请号:US13795982
申请日:2013-03-12
申请人: Relypsa, Inc.
发明人: Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Ramakrishnan Chidambaram , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Jonathan Mills , Werner Strüver
IPC分类号: A61K31/78
CPC分类号: A61K31/78 , A61K31/7004 , C08K5/053 , A61K2300/00
摘要: The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
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公开(公告)号:US20180125881A1
公开(公告)日:2018-05-10
申请号:US15865409
申请日:2018-01-09
申请人: Relypsa, Inc.
发明人: Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Ramakrishnan Chidambaram , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Jonathan Mills , Werner Strüver
IPC分类号: A61K31/78 , A61K31/7004 , C08K5/053
CPC分类号: A61K31/78 , A61K31/7004 , C08K5/053 , A61K2300/00
摘要: The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
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4.
公开(公告)号:US20170209481A1
公开(公告)日:2017-07-27
申请号:US15381881
申请日:2016-12-16
申请人: Relypsa, Inc.
发明人: Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Werner Strüver
摘要: The present invention is directed to methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio.
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公开(公告)号:US20130131202A1
公开(公告)日:2013-05-23
申请号:US13718140
申请日:2012-12-18
申请人: Relypsa, Inc.
发明人: Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Ramakrishnan Chidambaram , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Jonathan Mills , Werner Strüver
IPC分类号: C08K5/053
CPC分类号: A61K31/78 , A61K31/7004 , C08K5/053 , A61K2300/00
摘要: The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
摘要翻译: 本发明涉及线性多元醇和包含氟基团和酸基团的交联阳离子交换聚合物的盐的组合物。 这些组合物可用于结合胃肠道中的钾。
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