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公开(公告)号：US20220193614A1
公开(公告)日：2022-06-23
申请号：US17559792
申请日：2021-12-22
申请人： Repligen Corporation
发明人： Bao Le , Philip Yuen
摘要： Devices, systems, and methods for continually degassing/venting a feedstream within a filtration system. The filtration system may include a filter device utilizing hollow fiber filters to filter the feedstream. Additional venting hollow fiber filters vent gas from the filtration system to outside the filtration system. The venting hollow fiber filters may have ends which expose the interior lumens thereof to outside the filter unit to vent gases which pass through the walls of the hollow fiber filters. Degassed permeate thus flows through the filtering hollow fiber filters.
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公开(公告)号：US20230016575A1
公开(公告)日：2023-01-19
申请号：US17781791
申请日：2020-12-14
申请人： Repligen Corporation
发明人： Bao Le , Travis R. Ward
摘要： Embodiments of the present disclosure relate generally to systems and methods for perfusion cell culture involving alternating fluid flows between first and second flexible vessels. For example, a hollow fiber filter module may be attached to first and second culture vessels which each include inner and outer vessels. A pressure source may cause a pressure differential between the outer vessels, which may cause a responsive fluid flow between the inner vessels across a hollow fiber filtration unit.
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公开(公告)号：US20230211292A1
公开(公告)日：2023-07-06
申请号：US18071899
申请日：2022-11-30
申请人： Repligen Corporation
发明人： Steven V. Cates , Rudolf Pavlik , Bao Le
CPC分类号： B01D61/18 , C12M47/02 , B01D61/145 , B01F27/851 , B01D2315/10 , B01D63/02
摘要： Vessel configured to facilitate concentration of a product in a solution. The vessel may include outlet ports to deliver the solution to a processing system (such as a filtration system), and inlet ports. The inlet ports may be at progressively lower levels for return of fluid thereto reduced in volume as a result of filtration thereof. A smaller volume sump may be provided below a main tank of the vessel to facilitate concentration of the solution. The sump may include ridges facilitating collection of the product of interest from the solution, and/or reinforcing the sump walls, and optionally forming a vortex breaker. A spray ball may be provided to spray materials, such as buffer solution, into the vessel. The spray ball may direct materials to facilitate retrieval of product from the vessel. One or more components of the vessel may be advantageously formed of disposable material for single use thereof.
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公开(公告)号：US20230058593A1
公开(公告)日：2023-02-23
申请号：US18048874
申请日：2022-10-24
申请人： Repligen Corporation
发明人： Derek Carroll , Bao Le
摘要： The present disclosure is related to bioprocessing devices, systems, and methods, and particularly to sanitary connections for bioprocessing. The devices, systems, and methods described herein can relate to the sanitary connection of flow fittings, such as reducers, with considerations for ease of assembly and sealing. In some embodiments, the system may include a flow reducer, a ferrule and a gasket. The flow reducer may include a gasket channel, an overmold channel within the gasket channel, and one or more cavities within the overmold channel. The gasket may be overmolded within the gasket channel and extending within the one or more cavities.
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公开(公告)号：US11519539B2
公开(公告)日：2022-12-06
申请号：US16666970
申请日：2019-10-29
申请人： Repligen Corporation
发明人： Derek Carroll , Bao Le
摘要： The present disclosure is related to bioprocessing devices, systems, and methods, and particularly to sanitary connections for bioprocessing. The devices, systems, and methods described herein can relate to the sanitary connection of flow fittings, such as reducers, with considerations for ease of assembly and sealing. In some embodiments, the system may include a flow reducer, a ferrule and a gasket. The flow reducer may include a gasket channel, an overmold channel within the gasket channel, and one or more cavities within the overmold channel. The gasket may be overmolded within the gasket channel and extending within the one or more cavities.
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