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    ALTERNATING TANGENTIAL FLOW BIOREACTOR WITH HOLLOW FIBER SYSTEM AND METHOD OF USE
    4.
    发明申请
    ALTERNATING TANGENTIAL FLOW BIOREACTOR WITH HOLLOW FIBER SYSTEM AND METHOD OF USE 有权

    公开(公告)号：US20230016575A1

    公开(公告)日：2023-01-19

    申请号：US17781791

    申请日：2020-12-14

    申请人： Repligen Corporation

    发明人： Bao Le ,  Travis R. Ward

    IPC分类号： C12M1/00 ,  C12M1/12 ,  C12M1/34

    摘要： Embodiments of the present disclosure relate generally to systems and methods for perfusion cell culture involving alternating fluid flows between first and second flexible vessels. For example, a hollow fiber filter module may be attached to first and second culture vessels which each include inner and outer vessels. A pressure source may cause a pressure differential between the outer vessels, which may cause a responsive fluid flow between the inner vessels across a hollow fiber filtration unit.

    Chromatography Column Packing Medium Recovery
    5.
    发明申请
    Chromatography Column Packing Medium Recovery 审中-公开

    公开(公告)号：US20190270034A1

    公开(公告)日：2019-09-05

    申请号：US16308629

    申请日：2017-06-12

    申请人： Repligen Corporation

    发明人： Travis R. Ward ,  James Ronald Peyser ,  Dana Pentia ,  Evan Frankel

    IPC分类号： B01D15/22 ,  B01D15/20 ,  G01N30/56

    摘要： Systems include a chromatography column tube having an inlet and outlet and port assembly arranged in a wall of the column tube between flow distributors that together form a chamber within the tube that is filled with packing medium are described. The port assembly facilitates the removal of resin from the pre-packed column and the port assembly does not affect fluid flow in the normal use of the column for chromatographic separation or ability to maintain sanitary conditions within the column. Also described are methods that include attaching tubing to a pump and to a column inlet and a column outlet, opening the port assembly, attaching tubing to the port assembly and to a second reservoir, and pumping aqueous solution from a reservoir into the chamber and out through the port assembly into the second reservoir, thereby removing packing medium from the column along with the flowing aqueous solution.

    PRESSURE GAUGE RELIEF VALVE
    6.
    发明申请
    PRESSURE GAUGE RELIEF VALVE 有权

    公开(公告)号：US20230003600A1

    公开(公告)日：2023-01-05

    申请号：US17852557

    申请日：2022-06-29

    申请人： Repligen Corporation

    发明人： Travis R. Ward

    IPC分类号： G01L19/14 ,  G01L19/00 ,  G01L19/06

    摘要： A pressure gauge and/or relief valve which may be used in a single-use fluid system, such as a sterilizable fluid system. The pressure gauge and/or pressure relief valve may be formed of a disposable and/or sterilizable material, such as a non-metallic (e.g., polymeric) material. The material of the pressure gauge and/or pressure relief valve may be compatible with the material of a fluid-containing structure of the fluid system, such as to be bonded (e.g., welded) therewith. The fluid-containing structure may be retrofitted to integrate the pressure gauge and/or pressure relief valve therewith. The pressure gauge and/or pressure relief valve may have a simple configuration, such as a housing with a movable element therein. The movable element moves with respect to the housing to indicate pressure and/or to relieve pressure from within the housing and/or fluid-containing structure.