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公开(公告)号：US10100059B2
公开(公告)日：2018-10-16
申请号：US15374386
申请日：2016-12-09
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas , Kenneth S. Rehder , Srinivas Olepu
IPC: C07D491/107 , C07D231/14 , C07D401/12 , C07D401/14 , C07D487/08 , C07D405/12 , C07D417/12 , C07D413/12 , C07D409/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D403/14 , C07D403/12 , C07D471/08 , A61K45/06 , A61K31/454 , A61K31/415 , A61K31/5377 , A61K31/497 , A61K31/4439 , A61K31/55 , A61K31/427 , A61K31/422 , C07D417/14 , A61K31/4196 , A61K31/4245 , A61K31/439
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US10954247B2
公开(公告)日：2021-03-23
申请号：US15983519
申请日：2018-05-18
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas , Kenneth S. Rehder , Srinivas Olepu
IPC: C07D491/107 , C07D403/04 , A61K31/5377 , C07D401/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D409/04 , C07D403/12 , C07D417/12 , C07D403/06 , C07D231/14 , C07D471/08 , C07D413/12 , C07D401/14 , C07D417/14 , A61K45/06 , C07D487/08 , C07D407/12 , A61K31/55 , A61K31/427 , A61K31/422 , A61K31/415 , A61K31/4245 , A61K31/4196 , A61K31/454 , A61K31/497 , A61K31/4439 , A61K31/439 , C07D413/04
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US10377718B2
公开(公告)日：2019-08-13
申请号：US15023510
申请日：2015-06-05
Applicant: Research Triangle Institute , Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas
IPC: C07D231/14 , A61K45/06 , A61K31/415 , C07D405/12 , A61K31/422 , A61K31/454 , A61K31/4155 , A61K31/496 , C07D413/12 , C07D403/12 , C07D403/06 , C07D407/12
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US20170166577A1
公开(公告)日：2017-06-15
申请号：US15374386
申请日：2016-12-09
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas , Kenneth S. Rehder , Srinivas Olepu
IPC: C07D491/107 , A61K31/454 , C07D231/14 , A61K31/415 , A61K31/5377 , A61K31/497 , A61K31/4439 , C07D401/12 , C07D401/14 , A61K31/55 , C07D487/08 , C07D405/12 , A61K31/427 , C07D417/12 , A61K31/422 , C07D413/12 , C07D409/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , A61K31/4196 , A61K31/4245 , C07D403/14 , C07D403/12 , A61K31/439 , C07D471/08 , A61K45/06
CPC classification number: C07D491/107 , A61K31/415 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US11926612B2
公开(公告)日：2024-03-12
申请号：US16341597
申请日：2017-10-11
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , Kenneth S. Rehder
IPC: C07D233/90 , C07D249/10 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/14
CPC classification number: C07D401/12 , C07D233/90 , C07D249/10 , C07D401/04 , C07D401/14 , C07D403/12 , C07D417/14
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.
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Patent Agency Ranking
公开(公告)号：USRE49594E1
公开(公告)日：2023-08-01
申请号：US16974363
申请日：2020-05-04
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas , Kenneth S. Rehder , Srinivas Olepu
IPC: C07D491/107 , C07D403/12 , C07D231/14 , C07D403/06 , C07D407/12 , C07D413/12 , A61K31/415 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08
CPC classification number: C07D491/107 , A61K31/415 , A61K31/4196 , A61K31/422 , A61K31/427 , A61K31/4245 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US11267789B2
公开(公告)日：2022-03-08
申请号：US16448976
申请日：2019-06-21
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas
IPC: C07D231/14 , C07D405/12 , A61K45/06 , A61K31/415 , A61K31/4155 , A61K31/422 , C07D403/12 , A61K31/496 , C07D413/12 , C07D407/12 , C07D403/06 , A61K31/454
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US11142546B2
公开(公告)日：2021-10-12
申请号：US16090726
申请日：2017-03-23
Applicant: Research Triangle Institute
Inventor： Scott Runyon , Carla Hassler , Craig Shiner , Sanju Narayanan
IPC: C07K5/02 , C07K5/065 , A61K31/4015 , A61K31/55 , C07D207/416 , A61K31/495 , A61P25/20 , C07C237/24 , A61P25/30 , C07D211/60 , C07D223/20 , C07K11/00 , A61K38/00
Abstract: Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.
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公开(公告)号：US11535630B2
公开(公告)日：2022-12-27
申请号：US17082650
申请日：2020-10-28
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas , Kenneth S. Rehder , Srinivas Olepu
IPC: C07D491/107 , C07D403/12 , C07D231/14 , C07D403/06 , C07D407/12 , C07D413/12 , A61K31/415 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08 , C07D403/04 , C07D403/14
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US20160207889A1
公开(公告)日：2016-07-21
申请号：US15023510
申请日：2015-06-05
Applicant: Scott P. RUNYON , Rangan MAITRA , Sanju NARAYANAN , James Barnwell THOMAS , RESEARCH TRIANGLE INSTITUTE
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas
IPC: C07D231/14 , A61K45/06 , A61K31/415 , C07D405/12 , A61K31/422 , A61K31/454 , A61K31/4155 , A61K31/496 , C07D413/12
CPC classification number: C07D231/14 , A61K31/415 , A61K31/4155 , A61K31/422 , A61K31/454 , A61K31/496 , A61K45/06 , C07D403/06 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
Abstract translation: 本公开涉及apelin受体（APJ）的激动剂和这种激动剂的用途。
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