公开(公告)号：US20200062699A1

公开(公告)日：2020-02-27

申请号：US16612680

申请日：2018-05-10

Applicant: Research Triangle Institute

Inventor： Yanan ZHANG ,  Thuy NGUYEN ,  Nadezhda GERMAN

IPC: C07C275/38 ,  A61P25/30 ,  C07D213/643 ,  C07D205/04 ,  C07D207/335 ,  C07D211/38 ,  C07D215/12 ,  C07D239/26 ,  C07D295/135 ,  C07D333/20 ,  C07D487/08 ,  C07D491/107

Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

公开(公告)号：US20240174605A1

公开(公告)日：2024-05-30

申请号：US18279985

申请日：2022-03-01

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Yanan ZHANG ,  Dehui ZHANG

IPC: C07C311/37 ,  A61K31/167 ,  A61K31/18 ,  A61K31/381 ,  A61K31/40 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/496 ,  A61P25/28 ,  C07C237/42 ,  C07D213/40 ,  C07D213/75 ,  C07D213/76 ,  C07D213/81 ,  C07D213/82 ,  C07D277/56 ,  C07D295/16 ,  C07D333/38 ,  C07D401/12 ,  C07D417/12

CPC classification number: C07C311/37 ,  A61K31/167 ,  A61K31/18 ,  A61K31/381 ,  A61K31/40 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4453 ,  A61K31/4545 ,  A61K31/496 ,  A61P25/28 ,  C07C237/42 ,  C07D213/40 ,  C07D213/75 ,  C07D213/76 ,  C07D213/81 ,  C07D213/82 ,  C07D277/56 ,  C07D295/16 ,  C07D333/38 ,  C07D401/12 ,  C07D417/12 ,  C07C2601/02

Abstract: The present disclosure provides novel arylsulfonamide compounds as embodiments of the present disclosure. The compounds are believed to be orexin receptor agonists, useful for the treatment of diseases and conditions caused by reduced activity of orexin.

公开(公告)号：US20210332007A1

公开(公告)日：2021-10-28

申请号：US17369088

申请日：2021-07-07

Applicant: Research Triangle Institute

Inventor： Yanan ZHANG ,  Thuy NGUYEN ,  Nadezhda GERMAN

IPC: C07C275/38 ,  A61P25/30 ,  C07D205/04 ,  C07D207/335 ,  C07D211/38 ,  C07D213/643 ,  C07D215/12 ,  C07D239/26 ,  C07D295/135 ,  C07D333/20 ,  C07D487/08 ,  C07D491/107

Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.