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公开(公告)号：US20120122117A1
公开(公告)日：2012-05-17
申请号：US13145795
申请日：2010-01-22
申请人： David M. Lee , Eric Boilard , Michael H. Gelb , Reuben Gobezie
发明人： David M. Lee , Eric Boilard , Michael H. Gelb , Reuben Gobezie
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , C12Q1/44 , G01N2333/92 , G01N2800/105 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to the use of protein expression profiles of sPLA2 isoforms with clinical relevance to osteoarthritis (OA). In particular, the invention provides methods for diagnosing OA or determining risk factors for development of OA based on expression of sPLA2-IIA.
摘要翻译： 本发明涉及与骨关节炎（OA）具有临床相关性的sPLA2同种型的蛋白质表达谱的用途。 特别地，本发明提供了用于诊断OA或基于sPLA2-IIA表达确定OA发展的危险因素的方法。
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公开(公告)号：US08224579B2
公开(公告)日：2012-07-17
申请号：US11638254
申请日：2006-12-13
申请人： Reuben Gobezie , David M. Lee
发明人： Reuben Gobezie , David M. Lee
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/6887 , G01N33/6893 , G01N2500/00 , G01N2800/105
摘要： The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis (OA). In particular, the invention provides the identity of marker proteins whose expressions are correlated with OA, OA subtype, and/or OA progression. Methods and kits are described for using these protein expression profiles in the study and/or diagnosis of OA, in the determination of the degree of advancement of OA, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that modulate expression of these proteins or nucleic acid molecules encoding these proteins, in particular for the development of disease-modifying OA agents.
摘要翻译： 本发明涉及与骨关节炎（OA）临床相关的蛋白质表达谱的鉴定和应用。 特别地，本发明提供其表达与OA，OA亚型和/或OA进展相关的标记蛋白的身份。 描述了在研究和/或诊断OA中使用这些蛋白质表达谱的方法和试剂盒，以确定OA的进展程度，以及在治疗方案的选择和/或监测中。 本发明还涉及调节这些蛋白质或编码这些蛋白质的核酸分子的表达的药物的筛选，特别是用于发展改变疾病的OA剂。
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公开(公告)号：US08372594B2
公开(公告)日：2013-02-12
申请号：US13145795
申请日：2010-01-22
申请人： David M. Lee , Eric Boilard , Michael H. Gelb , Reuben Gobezie
发明人： David M. Lee , Eric Boilard , Michael H. Gelb , Reuben Gobezie
CPC分类号： G01N33/573 , C12Q1/44 , G01N2333/92 , G01N2800/105 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to the use of protein expression profiles of sPLA2 isoforms with clinical relevance to osteoarthritis (OA). In particular, the invention provides methods for diagnosing OA or determining risk factors for development of OA based on expression of sPLA2-IIA.
摘要翻译： 本发明涉及与骨关节炎（OA）具有临床相关性的sPLA2同种型的蛋白质表达谱的用途。 特别地，本发明提供了用于诊断OA或基于sPLA2-IIA表达确定OA发展的危险因素的方法。
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公开(公告)号：US20120190042A1
公开(公告)日：2012-07-26
申请号：US13145796
申请日：2010-01-22
申请人： Reuben Gobezie , David M. Lee
发明人： Reuben Gobezie , David M. Lee
IPC分类号： G01N33/566 , G01N33/573
CPC分类号： G01N33/6896 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N2800/105
摘要： The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis. In particular, the invention provides the identity of marker proteins whose expressions are correlated with OA, and/or OA progression. Methods and kits are described for using these protein expression profiles in the study and/or diagnosis of OA, in the determination of the degree of advancement of OA, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that modulate expression of these proteins or nucleic acid molecules encoding these proteins, in particular for the development of disease-modifying OA agents.
摘要翻译： 本发明涉及与骨关节炎临床相关的蛋白质表达谱的鉴定和应用。 特别地，本发明提供其表达与OA和/或OA进展相关的标记蛋白的身份。 描述了在研究和/或诊断OA中使用这些蛋白质表达谱的方法和试剂盒，以确定OA的进展程度，以及在治疗方案的选择和/或监测中。 本发明还涉及调节这些蛋白质或编码这些蛋白质的核酸分子的表达的药物的筛选，特别是用于发展改变疾病的OA剂。
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公开(公告)号：US20100292154A1
公开(公告)日：2010-11-18
申请号：US11917661
申请日：2006-06-16
IPC分类号： A61K38/00 , C07H21/04 , C40B40/10 , G01N33/566 , C12Q1/68 , G01N33/573 , G01N33/53 , C40B30/04 , A61P19/02
CPC分类号： G01N33/6893 , G01N2800/105
摘要： The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis (OA). In particular, the invention provides the identity of marker proteins whose expression is correlated with OA and OA progression. Methods and kits are described for using these protein expression profiles in the study and/or diagnosis of OA, in the determination of the degree of advancement of OA, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that modulate expression of these proteins or nucleic acid molecules encoding these proteins, in particular for the development of disease-modifying OA agents.
摘要翻译： 本发明涉及与骨关节炎（OA）临床相关的蛋白质表达谱的鉴定和应用。 特别地，本发明提供了表达与OA和OA进展相关的标记蛋白的身份。 描述了在研究和/或诊断OA中使用这些蛋白质表达谱的方法和试剂盒，以确定OA的进展程度，以及在治疗方案的选择和/或监测中。 本发明还涉及调节这些蛋白质或编码这些蛋白质的核酸分子的表达的药物的筛选，特别是用于发展改变疾病的OA剂。
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公开(公告)号：US20070207480A1
公开(公告)日：2007-09-06
申请号：US11638254
申请日：2006-12-13
申请人： Reuben Gobezie , David Lee
发明人： Reuben Gobezie , David Lee
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/6887 , G01N33/6893 , G01N2500/00 , G01N2800/105
摘要： The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis (OA). In particular, the invention provides the identity of marker proteins whose expressions are correlated with OA, OA subtype, and/or OA progression. Methods and kits are described for using these protein expression profiles in the study and/or diagnosis of OA, in the determination of the degree of advancement of OA, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that modulate expression of these proteins or nucleic acid molecules encoding these proteins, in particular for the development of disease-modifying OA agents.
摘要翻译： 本发明涉及与骨关节炎（OA）临床相关的蛋白质表达谱的鉴定和应用。 特别地，本发明提供其表达与OA，OA亚型和/或OA进展相关的标记蛋白的身份。 描述了在研究和/或诊断OA中使用这些蛋白质表达谱的方法和试剂盒，以确定OA的进展程度，以及在治疗方案的选择和/或监测中。 本发明还涉及调节这些蛋白质或编码这些蛋白质的核酸分子的表达的药物的筛选，特别是用于发展改变疾病的OA剂。
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