公开(公告)号：US20210405060A1

公开(公告)日：2021-12-30

申请号：US17161505

申请日：2021-01-28

申请人： Revolution Medicines, Inc.

发明人： Gregory L. VERDINE ,  M. James NICHOLS ,  Sharon A. TOWNSON ,  Uddhav Kumar SHIGDEL ,  Seung-Joo LEE ,  Dylan T. STILES ,  Neville J. ANTHONY

IPC分类号： G01N33/68 ,  C07K1/13 ,  C07K5/02 ,  C07K7/64 ,  C12Q1/533 ,  G01N33/566 ,  C07K5/062 ,  C07K1/08 ,  C07K5/083

摘要： The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins.

公开(公告)号：US20240044876A1

公开(公告)日：2024-02-08

申请号：US18128799

申请日：2023-03-30

申请人： Revolution Medicines, Inc.

发明人： Gregory L. VERDINE ,  David W. WHITE ,  David M. ARMISTEAD ,  Deborah J. PALESTRANT ,  Brian Y. CHOW ,  Chris K. VARMA ,  Mathew Edward SOWA

IPC分类号： G01N33/53 ,  C40B30/04 ,  G01N33/68

CPC分类号： G01N33/5308 ,  C40B30/04 ,  G01N33/68 ,  G01N33/6848 ,  G01N2500/04

摘要： Disclosed herein are methods for identifying novel drug candidates.

公开(公告)号：US20220082556A1

公开(公告)日：2022-03-17

申请号：US17129571

申请日：2020-12-21

申请人： Revolution Medicines, Inc.

发明人： Gregory L. VERDINE ,  David W. WHITE ,  David M. ARMISTEAD ,  Deborah J. PALESTRANT ,  Brian Y. CHOW ,  Chris K. VARMA ,  Mathew Edward SOWA

IPC分类号： G01N33/53 ,  C40B30/04 ,  G01N33/68

摘要： Disclosed herein are methods for identifying novel drug candidates.