公开(公告)号：US20120004160A1

公开(公告)日：2012-01-05

申请号：US13202569

申请日：2010-02-18

申请人： Richard Antonius Jozef Janssen ,  Anton De Groot ,  Annemarie Nicolette Lekkerkerker ,  Eric Charles Meldrum ,  Nicola Thompson ,  Marion Catherine Dickson ,  Keith Paul Ray ,  Susan Heather Boyce

发明人： Richard Antonius Jozef Janssen ,  Anton De Groot ,  Annemarie Nicolette Lekkerkerker ,  Eric Charles Meldrum ,  Nicola Thompson ,  Marion Catherine Dickson ,  Keith Paul Ray ,  Susan Heather Boyce

IPC分类号： A61K38/00 ,  C12Q1/02 ,  C40B30/04 ,  A61K31/7088 ,  C07H21/04 ,  A61P17/06 ,  A61P31/04 ,  A61P19/02 ,  A61P37/08 ,  A61P37/02 ,  A61P41/00 ,  A61P11/06 ,  G01N33/53 ,  A61P1/00

CPC分类号： A61K31/7088 ,  A61K38/177 ,  A61K38/43 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/12 ,  C12N2330/31 ,  C12N2330/51 ,  G01N33/5055

摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the inhibition of the activation of macrophages. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by activation of macrophages including infections, allograft reactions, inflammation, allergic and autoimmune diseases, metabolic disease, cardiovascular disease, tissue injury, and cancer.

摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致抑制巨噬细胞的活化。 此外，本发明涉及用于治疗特征为活化巨噬细胞，包括感染，同种异体移植反应，炎症，过敏性和自身免疫性疾病，代谢疾病，心血管疾病，组织损伤和癌症的病症的组合物和方法。

公开(公告)号：US20110306655A1

公开(公告)日：2011-12-15

申请号：US13202567

申请日：2010-02-18

申请人： Richard Antonius Jozef Janssen ,  Anton De Groot ,  Annemarie Nicolette Lekkerkerker ,  Eric Charles Meldrum ,  Nicola Thompson ,  Dilniya Fattah

发明人： Richard Antonius Jozef Janssen ,  Anton De Groot ,  Annemarie Nicolette Lekkerkerker ,  Eric Charles Meldrum ,  Nicola Thompson ,  Dilniya Fattah

IPC分类号： A61K31/713 ,  C40B30/04 ,  C07H21/02 ,  A61P35/00 ,  A61P29/00 ,  A61P37/06 ,  A61P37/08 ,  C40B30/06 ,  A61P31/00

CPC分类号： A61K31/713 ,  C12N15/1136 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/12

摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the inhibition of the maturation of dendritic cells. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by maturation of dendritic cells including infections, allograft reactions, inflammation, allergic and autoimmune diseases, and cancer.

摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致树突细胞成熟的抑制。 此外，本发明涉及其用于治疗以树突状细胞成熟为特征的病症的组合物和方法，包括感染，同种异体移植反应，炎症，过敏性和自身免疫性疾病以及癌症。

公开(公告)号：US20120035245A1

公开(公告)日：2012-02-09

申请号：US13202566

申请日：2010-02-18

申请人： Richard Antonius Jozef Janssen ,  Anton De Groot ,  Annemarie Nicolette Lekkerkerker ,  Eric Charles Meldrum ,  Nicola Thompson

发明人： Richard Antonius Jozef Janssen ,  Anton De Groot ,  Annemarie Nicolette Lekkerkerker ,  Eric Charles Meldrum ,  Nicola Thompson

IPC分类号： A61K31/7088 ,  G01N21/78 ,  C40B30/04 ,  C07H21/00 ,  A61P37/08 ,  A61P29/00 ,  A61P19/02 ,  A61P1/00 ,  A61P17/06 ,  C07H21/02 ,  A61P11/06 ,  C40B30/06 ,  A61P37/00

CPC分类号： G01N33/5047 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14

摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the stabilization of mast cells, in particular that inhibit mast cell degranulation. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by mast cell degranulation and/or inflammation, including allergic rhinitis.

摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致肥大细胞的稳定化，特别是抑制肥大细胞脱粒。 此外，本发明涉及其用于治疗以肥大细胞脱粒和/或炎症为特征的病症的组合物和方法，包括过敏性鼻炎。

公开(公告)号：US10048250B2

公开(公告)日：2018-08-14

申请号：US15669213

申请日：2017-08-04

申请人： Richard Antonius Jozef Janssen ,  Annemarie Nicolette Lekkerkerker ,  Thomas Van Es ,  Johannes Melchior Petrus Stallen

发明人： Richard Antonius Jozef Janssen ,  Annemarie Nicolette Lekkerkerker ,  Thomas Van Es ,  Johannes Melchior Petrus Stallen

IPC分类号： G01N33/50 ,  C07K16/28 ,  C12N15/113 ,  C07K16/40

摘要： The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic conditions. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic conditions. The invention further provides in vitro methods for reduction or inhibition of macrophage differentiation into alternatively-activated macrophages (M2).

公开(公告)号：US20050037001A1

公开(公告)日：2005-02-17

申请号：US10856272

申请日：2004-05-28

申请人： Wilfred Thomas Germeraad ,  Ton Logtenberg ,  Annemarie Nicolette Lekkerkerker

发明人： Wilfred Thomas Germeraad ,  Ton Logtenberg ,  Annemarie Nicolette Lekkerkerker

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K47/48 ,  A61P9/10 ,  A61P25/28 ,  A61P31/20 ,  A61P35/00 ,  A61P37/00 ,  C07K14/47 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  C07K19/00 ,  C12N15/62 ,  C12N15/85

CPC分类号： C07K16/00 ,  A61K39/00 ,  A61K47/6849 ,  C07K14/4748 ,  C07K16/30 ,  C07K16/3007 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/30

摘要： A conjugate for targeting antigen-presenting cells, including at least one antigenic moiety conjugated to a targeting moiety that is capable of binding to a cell surface structure of an antigen-presenting cell, wherein the conjugate is capable of being internalized and processed by the antigen-presenting cells such as to cause processed antigenic moiety fragments thereof to be presented via MHC class I and MHC class II molecules of the antigen-presenting cell, to a nucleic acid sequence including, a nucleic acid sequence encoding the antigenic moiety and a nucleic acid sequence encoding the targeting moiety, to a host cell to a method for producing a conjugate, and for generating an antigen-presenting cell capable of eliciting an immune response to such antigen-presenting cell, to a pharmaceutical composition comprising a conjugate or an antigen-presenting cell and their use for vaccination, and as a medicament.

摘要翻译： 用于靶向抗原呈递细胞的缀合物，包括与能够结合抗原呈递细胞的细胞表面结构的靶向部分缀合的至少一个抗原部分，其中所述缀合物能够被所述抗原内化和加工 将抗原呈递细胞的MHC I类和II类分子的经处理的抗原部分片段提供给核酸序列，所述核酸序列包括编码抗原部分的核酸序列和核酸 编码靶向部分的序列，宿主细胞到产生缀合物的方法，以及用于产生能够引起对这种抗原呈递细胞的免疫应答的抗原呈递细胞，包含缀合物或抗原决定簇的药物组合物， 呈递细胞及其用于疫苗接种的药物。