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1.发明授权Methods for identifying and compounds useful for increasing the functional activity and cell surface expression of CF-associated mutant cystic fibrosis transmembrane conductance regulator 失效用于鉴定和用于增加CF相关突变型囊性纤维化跨膜传导调节物的功能活性和细胞表面表达的化合物的方法公开(公告)号：US08765376B2
公开(公告)日：2014-07-01
申请号：US13063333
申请日：2009-09-10
申请人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Tessari
发明人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Tessari
IPC分类号： A61K31/70 , A61K31/7088 , A61P1/16 , C12N15/11 , G01N33/68 , C07H21/02 , C12Q1/68 , C07H21/04
CPC分类号： G01N33/5041 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12N2330/31 , C12N2330/51 , C12Q1/6883 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/382
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF-associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致蛋白质细胞转运的调节，特别是CF相关突变型囊性纤维变性跨膜电导调节剂（CFTR）的调节。 此外，本发明涉及其用于治疗以ER相关蛋白错误折叠为特征的病症的组合物和方法，以及包括囊性纤维化（CF）在内的疾病相关蛋白的异常细胞运送。
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2.发明申请METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION 审中-公开识别和化合物的方法用于诊断和治疗涉及炎症的疾病公开(公告)号：US20120035245A1
公开(公告)日：2012-02-09
申请号：US13202566
申请日：2010-02-18
申请人： Richard Antonius Jozef Janssen , Anton De Groot , Annemarie Nicolette Lekkerkerker , Eric Charles Meldrum , Nicola Thompson
发明人： Richard Antonius Jozef Janssen , Anton De Groot , Annemarie Nicolette Lekkerkerker , Eric Charles Meldrum , Nicola Thompson
IPC分类号： A61K31/7088 , G01N21/78 , C40B30/04 , C07H21/00 , A61P37/08 , A61P29/00 , A61P19/02 , A61P1/00 , A61P17/06 , C07H21/02 , A61P11/06 , C40B30/06 , A61P37/00
CPC分类号： G01N33/5047 , A61K31/7105 , A61K31/713 , C12N15/1138 , C12N2310/11 , C12N2310/14
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the stabilization of mast cells, in particular that inhibit mast cell degranulation. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by mast cell degranulation and/or inflammation, including allergic rhinitis.
摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致肥大细胞的稳定化，特别是抑制肥大细胞脱粒。 此外，本发明涉及其用于治疗以肥大细胞脱粒和/或炎症为特征的病症的组合物和方法，包括过敏性鼻炎。
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公开(公告)号：US10048250B2
公开(公告)日：2018-08-14
申请号：US15669213
申请日：2017-08-04
申请人： Richard Antonius Jozef Janssen , Annemarie Nicolette Lekkerkerker , Thomas Van Es , Johannes Melchior Petrus Stallen
发明人： Richard Antonius Jozef Janssen , Annemarie Nicolette Lekkerkerker , Thomas Van Es , Johannes Melchior Petrus Stallen
IPC分类号： G01N33/50 , C07K16/28 , C12N15/113 , C07K16/40
摘要： The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic conditions. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic conditions. The invention further provides in vitro methods for reduction or inhibition of macrophage differentiation into alternatively-activated macrophages (M2).
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4.发明申请METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR INCREASING THE FUNCTIONAL ACTIVITY AND CELL SURFACE EXPRESSION OF CF-ASSOCIATED MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 失效用于鉴定和化合物的方法用于增加CF相关突变体CYSTIC FIBROSIS TRANSMEMBRARE CONDUCTANCE REGULATOR的功能活性和细胞表面表达公开(公告)号：US20110245322A1
公开(公告)日：2011-10-06
申请号：US13063333
申请日：2009-09-10
申请人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Tessari
发明人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Tessari
IPC分类号： A61K31/713 , G01N33/68 , C40B30/04 , C07H21/02 , C07H21/00 , C07H21/04 , A61K31/7088 , A61P11/06 , A61P29/00 , A61P11/00 , A61P25/16 , A61P25/28 , A61P3/08 , A61P1/16 , A61P3/10
CPC分类号： G01N33/5041 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12N2330/31 , C12N2330/51 , C12Q1/6883 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/382
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF-associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致蛋白质细胞转运的调节，特别是CF相关突变型囊性纤维变性跨膜电导调节剂（CFTR）的调节。 此外，本发明涉及其用于治疗以ER相关蛋白错误折叠为特征的病症的组合物和方法，以及包括囊性纤维化（CF）在内的疾病相关蛋白的异常细胞运送。
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5.发明申请METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION 审中-公开识别和化合物的方法用于诊断和治疗涉及炎症的疾病公开(公告)号：US20110306655A1
公开(公告)日：2011-12-15
申请号：US13202567
申请日：2010-02-18
申请人： Richard Antonius Jozef Janssen , Anton De Groot , Annemarie Nicolette Lekkerkerker , Eric Charles Meldrum , Nicola Thompson , Dilniya Fattah
发明人： Richard Antonius Jozef Janssen , Anton De Groot , Annemarie Nicolette Lekkerkerker , Eric Charles Meldrum , Nicola Thompson , Dilniya Fattah
IPC分类号： A61K31/713 , C40B30/04 , C07H21/02 , A61P35/00 , A61P29/00 , A61P37/06 , A61P37/08 , C40B30/06 , A61P31/00
CPC分类号： A61K31/713 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/12
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the inhibition of the maturation of dendritic cells. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by maturation of dendritic cells including infections, allograft reactions, inflammation, allergic and autoimmune diseases, and cancer.
摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致树突细胞成熟的抑制。 此外，本发明涉及其用于治疗以树突状细胞成熟为特征的病症的组合物和方法，包括感染，同种异体移植反应，炎症，过敏性和自身免疫性疾病以及癌症。
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6.发明申请MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开分子靶向和化合物及其鉴别方法，有助于治疗神经病变性疾病公开(公告)号：US20110077283A1
公开(公告)日：2011-03-31
申请号：US12865281
申请日：2009-02-03
申请人： David Frederik Fischer , Richard Antonius Jozef Janssen , Remko De Pril , Desiré Maria Petronella Catharina Van Steenhoven , Seung Kwak , David S. Howland , Ethan Signer
发明人： David Frederik Fischer , Richard Antonius Jozef Janssen , Remko De Pril , Desiré Maria Petronella Catharina Van Steenhoven , Seung Kwak , David S. Howland , Ethan Signer
IPC分类号： A61K31/713 , G01N33/53 , C40B30/04 , C07H21/02 , A61P25/00
CPC分类号： G01N33/6896 , C12N15/86 , C12N2710/10343 , G01N2500/04 , G01N2500/10 , G01N2800/2835
摘要： The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation, and/or altering huntingtin protein conformation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and protein aggregation diseases more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntington's disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these
摘要翻译： 本发明涉及用于鉴定能够抑制突变型亨廷蛋白蛋白，抑制或降低多聚谷氨酰胺诱导的蛋白质聚集和/或改变亨廷顿蛋白质构象的试剂的方法和测定法，该抑制可用于预防，改善和/或治疗 神经变性疾病和蛋白质聚集疾病。 特别地，本发明提供用于鉴定用于预防和/或治疗亨廷顿氏病的药剂的方法和测定。 本发明提供了基于这些的多肽和核酸TARGET和siRNA序列
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7.发明申请Methods for Identifying and Compounds Useful for Increasing the Functional Activity and Cell Surface Expression of CF-Associated Mutant Cystic Fibrosis Transmembrance Conductance Regulator 审中-公开用于增加CF相关突变体囊性纤维化跨膜电导调节剂的功能活性和细胞表面表达的鉴定和化合物的方法公开(公告)号：US20140256790A1
公开(公告)日：2014-09-11
申请号：US14282090
申请日：2014-05-20
申请人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Angela Tessari
发明人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Angela Tessari
IPC分类号： G01N33/50 , C12N15/113 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/5041 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12N2330/31 , C12N2330/51 , C12Q1/6883 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/382
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF-associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致蛋白质细胞转运的调节，特别是CF相关突变型囊性纤维变性跨膜电导调节剂（CFTR）的调节。 此外，本发明涉及其用于治疗以ER相关蛋白错误折叠为特征的病症的组合物和方法，以及包括囊性纤维化（CF）在内的疾病相关蛋白的异常细胞运送。
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8.发明申请公开(公告)号：US20180045713A1
公开(公告)日：2018-02-15
申请号：US15669213
申请日：2017-08-04
申请人： Richard Antonius Jozef JANSSEN , Annemarie Nicolette LEKKERKERKER , Thomas VAN ES , Johannes Melchior Petrus STALLEN
发明人： Richard Antonius Jozef JANSSEN , Annemarie Nicolette LEKKERKERKER , Thomas VAN ES , Johannes Melchior Petrus STALLEN
IPC分类号： G01N33/50 , C07K16/28 , C12N15/113 , C07K16/40
CPC分类号： G01N33/5055 , C07K16/2869 , C07K16/40 , C12N15/113 , C12N2310/14 , C12N2310/531
摘要： The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic conditions. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic conditions. The invention further provides in vitro methods for reduction or inhibition of macrophage differentiation into alternatively-activated macrophages (M2).
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9.发明申请METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION 审中-公开识别和化合物的方法用于诊断和治疗涉及炎症的疾病公开(公告)号：US20120004160A1
公开(公告)日：2012-01-05
申请号：US13202569
申请日：2010-02-18
申请人： Richard Antonius Jozef Janssen , Anton De Groot , Annemarie Nicolette Lekkerkerker , Eric Charles Meldrum , Nicola Thompson , Marion Catherine Dickson , Keith Paul Ray , Susan Heather Boyce
发明人： Richard Antonius Jozef Janssen , Anton De Groot , Annemarie Nicolette Lekkerkerker , Eric Charles Meldrum , Nicola Thompson , Marion Catherine Dickson , Keith Paul Ray , Susan Heather Boyce
IPC分类号： A61K38/00 , C12Q1/02 , C40B30/04 , A61K31/7088 , C07H21/04 , A61P17/06 , A61P31/04 , A61P19/02 , A61P37/08 , A61P37/02 , A61P41/00 , A61P11/06 , G01N33/53 , A61P1/00
CPC分类号： A61K31/7088 , A61K38/177 , A61K38/43 , C12N15/111 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12N2330/31 , C12N2330/51 , G01N33/5055
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the inhibition of the activation of macrophages. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by activation of macrophages including infections, allograft reactions, inflammation, allergic and autoimmune diseases, metabolic disease, cardiovascular disease, tissue injury, and cancer.
摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致抑制巨噬细胞的活化。 此外，本发明涉及用于治疗特征为活化巨噬细胞，包括感染，同种异体移植反应，炎症，过敏性和自身免疫性疾病，代谢疾病，心血管疾病，组织损伤和癌症的病症的组合物和方法。
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