公开(公告)号：US20240083910A1

公开(公告)日：2024-03-14

申请号：US18257003

申请日：2021-12-14

申请人： Richard BERGER ,  Christopher Douglas COX ,  Brendan M. CROWLEY ,  Marc LABROLI ,  Michael Aaron PLOTKIN ,  Izzat Tiedje RAHEEM ,  Deyou SHA ,  Anthony SHAW ,  Jason W. SKUDLAREK ,  Ling TONG ,  Merck Sharp & Dohme LLC

发明人： Richard Thaddeus Berger, JR. ,  Christopher Douglas Cox ,  Brendan M. Crowley ,  Marc Labroli ,  Michael Aaron Plotkin ,  Izzat Tiedje Raheem ,  Deyou Sha ,  Anthony W. Shaw ,  Jason W. Skudlarek ,  Ling Tong

IPC分类号： C07D498/04 ,  A61K31/444 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61P31/22 ,  C07D401/14 ,  C07D519/00

CPC分类号： C07D498/04 ,  A61K31/444 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61P31/22 ,  C07D401/14 ,  C07D519/00

摘要： The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

公开(公告)号：US20240067657A1

公开(公告)日：2024-02-29

申请号：US18258903

申请日：2021-12-21

申请人： Kira A. ARMACOST ,  Richard Thaddeus BERGER ,  Andrew J. COOKE ,  Christopher Douglas COX ,  Brendan M. CROWLEY ,  Marc LABROLI ,  Michael Aaron PLOTKIN ,  Izzat Tiedje RAHEEM ,  Anthony W. SHAW ,  Kelly-Ann S. SCHLEGEL ,  Jason W. SKUDLAREK ,  Ling TONG ,  Merck Sharp & Dohme LLC

发明人： Kira A. Armacost ,  Richard Thaddeus Berger, Jr. ,  Andrew J. Cooke ,  Christopher Douglas Cox ,  Brendan M. Crowley ,  Marc Labroli ,  Michael Aaron Plotkin ,  Izzat Tiedje Raheem ,  Anthony W. Shaw ,  Kelly-Ann S. Schlegel ,  Jason W. Skudlarek ,  Ling Tong

IPC分类号： C07D498/04 ,  A61K31/517 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D519/00

CPC分类号： C07D498/04 ,  A61K31/517 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D519/00

摘要： The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

公开(公告)号：US20240059693A1

公开(公告)日：2024-02-22

申请号：US18256997

申请日：2021-12-14

申请人： Merck Sharp & Dohme LLC

发明人： Ronald K. Chang ,  Andrew J. Cooke, JR. ,  Christopher Douglas Cox ,  Marc Labroli ,  Izzat Tiedje Raheem ,  Jack D. Scott ,  Jeffrey W. Schubert ,  Jason W. Skudlarek ,  Zheng Tan ,  Ling Tong

IPC分类号： C07D487/04 ,  C07D519/00 ,  C07D403/14 ,  C07D403/06 ,  C07D413/14 ,  A61K31/517 ,  A61P31/22

CPC分类号： C07D487/04 ,  C07D519/00 ,  C07D403/14 ,  C07D403/06 ,  C07D413/14 ,  A61K31/517 ,  A61P31/22

摘要： The present invention relates to novel Fused Bicyclic Pyrazole Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and R6 are as defined herein. The present invention also relates to compositions comprising at least one Fused Bicyclic Pyrazole Derivative, and methods of using the Fused Bicyclic Pyrazole Derivatives for treating or preventing a herpesvirus infection in a patient.