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1.发明公开公开(公告)号：US20240083910A1
公开(公告)日：2024-03-14
申请号：US18257003
申请日：2021-12-14
申请人： Richard BERGER , Christopher Douglas COX , Brendan M. CROWLEY , Marc LABROLI , Michael Aaron PLOTKIN , Izzat Tiedje RAHEEM , Deyou SHA , Anthony SHAW , Jason W. SKUDLAREK , Ling TONG , Merck Sharp & Dohme LLC
发明人： Richard Thaddeus Berger, JR. , Christopher Douglas Cox , Brendan M. Crowley , Marc Labroli , Michael Aaron Plotkin , Izzat Tiedje Raheem , Deyou Sha , Anthony W. Shaw , Jason W. Skudlarek , Ling Tong
IPC分类号： C07D498/04 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61P31/22 , C07D401/14 , C07D519/00
CPC分类号： C07D498/04 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61P31/22 , C07D401/14 , C07D519/00
摘要： The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.
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2.发明公开公开(公告)号：US20240067657A1
公开(公告)日：2024-02-29
申请号：US18258903
申请日：2021-12-21
申请人： Kira A. ARMACOST , Richard Thaddeus BERGER , Andrew J. COOKE , Christopher Douglas COX , Brendan M. CROWLEY , Marc LABROLI , Michael Aaron PLOTKIN , Izzat Tiedje RAHEEM , Anthony W. SHAW , Kelly-Ann S. SCHLEGEL , Jason W. SKUDLAREK , Ling TONG , Merck Sharp & Dohme LLC
发明人： Kira A. Armacost , Richard Thaddeus Berger, Jr. , Andrew J. Cooke , Christopher Douglas Cox , Brendan M. Crowley , Marc Labroli , Michael Aaron Plotkin , Izzat Tiedje Raheem , Anthony W. Shaw , Kelly-Ann S. Schlegel , Jason W. Skudlarek , Ling Tong
IPC分类号： C07D498/04 , A61K31/517 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D519/00
CPC分类号： C07D498/04 , A61K31/517 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D519/00
摘要： The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.
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公开(公告)号：US20240050378A1
公开(公告)日：2024-02-15
申请号：US18254898
申请日：2021-12-01
IPC分类号： A61K9/51 , A61K31/7088
CPC分类号： A61K9/5123 , A61K9/5146 , A61K31/7088
摘要： The present disclosure provides, among other things, lipid nanoparticle formulations that include monoester cationic lipids. The present invention also provides compositions that include monoester cationic lipid nanoparticles and nucleic acids. The present disclosure also provides lipid nanoparticles encapsulating agents. The present disclosure further provides methods of producing lipid nanoparticles with encapsulated nucleic acids.
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4.发明公开公开(公告)号：US20240059693A1
公开(公告)日：2024-02-22
申请号：US18256997
申请日：2021-12-14
发明人： Ronald K. Chang , Andrew J. Cooke, JR. , Christopher Douglas Cox , Marc Labroli , Izzat Tiedje Raheem , Jack D. Scott , Jeffrey W. Schubert , Jason W. Skudlarek , Zheng Tan , Ling Tong
IPC分类号： C07D487/04 , C07D519/00 , C07D403/14 , C07D403/06 , C07D413/14 , A61K31/517 , A61P31/22
CPC分类号： C07D487/04 , C07D519/00 , C07D403/14 , C07D403/06 , C07D413/14 , A61K31/517 , A61P31/22
摘要： The present invention relates to novel Fused Bicyclic Pyrazole Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and R6 are as defined herein. The present invention also relates to compositions comprising at least one Fused Bicyclic Pyrazole Derivative, and methods of using the Fused Bicyclic Pyrazole Derivatives for treating or preventing a herpesvirus infection in a patient.
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公开(公告)号：US20230077499A1
公开(公告)日：2023-03-16
申请号：US17783870
申请日：2020-12-16
发明人： Kira A. Armacost , Andrew John Cooke , Robert Patrick Hayes , Marc A. Labroli , Michael Aaron Plotkin , Izzat Tiedje Raheem , Jeffrey W. Schubert , David M. Tellers
IPC分类号： A61K31/4439 , C07D413/06 , C07D413/14 , A61K31/517 , A61K31/538 , A61K31/4725 , A61K31/4709 , A61P31/22 , A61K45/06
摘要： The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, and R4 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.
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