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1.发明授权Method and apparatus for making concentrated plasma and/or tissue sealant 有权用于制备浓缩等离子体和/或组织密封剂的方法和装置
公开(公告)号：US6063297A
公开(公告)日：2000-05-16
申请号：US128189
申请日：1998-08-03
IPC分类号： A61K35/14 , A61L24/10 , A61M1/36 , B01D61/18 , B01D63/16 , B01D67/00 , B04B5/04 , C07K14/745 , B01D21/26 , B01D61/14
CPC分类号： B01D67/0093 , A61L24/106 , A61M1/3693 , A61M1/3696 , B01D61/18 , B01D63/16 , B04B5/0442 , B01D2323/30 , B04B2005/0478
摘要： An inexpensive device with a disposable cartridge for preparing tissue sealant is disclosed. The device is particularly applicable to stat preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate (from the device) with a solution of calcium and thrombin is also disclosed. Preparation in the operating room of 5 cc sealant from 50 cc patient blood requires less than 15 minutes and only one simple operator step. There is no risk of tracking error because processing can be done in the operating room. Chemicals added may be limited to anticoagulant (e.g., citrate) and calcium chloride. The disposable cartridge may fit in the palm of the hand and is hermetically sealed to eliminate possible exposure to patient blood and ensure sterility. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods.Antifibrinolytic agents (such as aprotinin) are not necessary because the tissue sealant contains high concentrations of natural inhibitors of fibrinolysis from the patient's blood. The tissue sealant also contains patient platelets and additional factors not present in available fibrin sealants that promote wound healing.
摘要翻译： 公开了一种具有用于制备组织密封剂的一次性盒的廉价装置。 该装置特别适用于自体组织密封胶的状态制备。 还公开了一种密封组织的方法，其中在将富含血小板的血浆浓缩物（来自该装置）与钙和凝血酶的溶液混合之后立即施加组织密封剂。 在手术室内从50cc患者血液制备5cc密封胶需要少于15分钟，只有一个简单的操作步骤。 没有跟踪错误的风险，因为可以在手术室进行处理。 加入的化学物质可能限于抗凝血剂（如柠檬酸盐）和氯化钙。 一次性药筒可以装配在手掌中并被密封，以消除患者血液的可能暴露并确保不育。 粘合剂和拉伸强度与用沉淀法制成的合并的血液纤维蛋白密封剂相当或优于其他。 抗纤维蛋白溶解剂（如抑肽酶）不是必需的，因为组织密封剂含有高浓度的患者血液中的纤维蛋白溶解天然抑制剂。 组织密封剂还含有患者血小板和不存在于促进伤口愈合的可用纤维蛋白密封剂中的另外的因素。
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公开(公告)号：US6132396A
公开(公告)日：2000-10-17
申请号：US128374
申请日：1998-08-03
CPC分类号： A61B17/00491 , A61B2017/00495 , A61M5/315 , B05C17/00516
摘要： A device and method for applying a fibrinogen-based tissue sealant to seamlessly connect human or animal tissues or organ parts, to seal wounds, stop bleeding and the like by mixing fibrin or fibrinogen with blood clot-promoting coagulation factors are disclosed. The device includes two cylindrical compartments for separately containing the separate fluid components of the sealant preparation, which are simultaneously displaced from the respective compartments by plungers commonly depressable with the same effective strokes. The plungers may be depressed directly or by a common mechanism (e.g., rack and pinion) for accurately controlling the rate of dispensing fluid. The cylindrical compartments are of the same or different cross-sectional area and are arranged either concentrically or side-by-side. The device further includes structure for merging the two fluid components within an outer sleeve housing an inner needle. The sleeve and needle contain conduits for the flow of the two fluid sealant components as they are expressed from the respective compartments. Also disclosed are a convenient device for filling the two compartments, structure for mixing the fluid components, and for atomizing the effluent sealant fluid stream (i.e., spraying).
摘要翻译： 公开了一种用于通过将纤维蛋白或纤维蛋白原与血块促进凝血因子混合来应用基于纤维蛋白原的组织密封剂来使人或动物组织或器官部分无缝连接以密封伤口，止血等的装置和方法。 该装置包括两个圆柱形隔室，用于分别容纳密封剂制剂的分开的流体组分，这些分离的流体组分通过同样有效冲程通常可压下的柱塞从相应的隔室同时移位。 柱塞可以直接地或通过用于精确地控制分配流体的速率的公共机构（例如，齿条和小齿轮）来压下。 圆柱形隔室具有相同或不同的横截面积，并且同心地或并排布置。 该装置还包括用于在容纳内针的外套筒内合并两个流体部件的结构。 套筒和针头包含用于两个流体密封剂组件的流动的导管，因为它们从相应的隔室表达。 还公开了一种用于填充两个隔室的便利装置，用于混合流体组分的结构，以及用于雾化流出物密封剂流体流（即，喷雾）。
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3.发明授权Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change 失效可回收的生物人造植入物具有允许氧的快速扩散和对生理变化的快速生物反应的尺寸
公开(公告)号：US5855613A
公开(公告)日：1999-01-05
申请号：US542506
申请日：1995-10-13
CPC分类号： A61K9/0024 , A61F2/022 , A61L27/20 , A61L27/36 , A61L27/38
摘要： Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology. Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
摘要翻译： 描述了生物人造植入物及其制造和使用的方法，特别是生物人造胰腺。 特别地，植入物可以是包围细胞的薄片，可以在延长的时间段内完全生物相容，并且可能不诱导纤维化。 含高密度细胞的薄片优选是完全可回收的，并且具有允许通过营养物和氧气的快速扩散维持最佳组织存活力的尺寸，并且还允许胰岛素和/或其它生物活性剂在分解速率方面的快速变化 改变生理学。 包含在生物人造植入物中的活细胞，组织，药物，药物和/或酶的植入物可以进行治疗和/或预防疾病。
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4.发明授权RETRIEVABLE BIOARTIFICIAL IMPLANTS HAVING DIMENSIONS ALLOWING RAPID DIFFUSION OF OXYGEN AND RAPID BIOLOGICAL RESPONSE TO PHYSIOLOGICAL CHANGE, PROCESSES FOR THEIR MANUFACTURE, AND METHODS FOR THEIR USE 失效具有尺寸的可回收生物植入物允许氧气的快速扩张和对生理变化的快速生物反应，其制造方法及其使用方法公开(公告)号：US06372244B1
公开(公告)日：2002-04-16
申请号：US09648050
申请日：2000-08-25
IPC分类号： A61F1300
摘要： Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology. Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
摘要翻译： 描述了生物人造植入物及其制造和使用的方法，特别是生物人造胰腺。 特别地，植入物可以是包围细胞的薄片，可以在延长的时间段内完全生物相容，并且可能不诱导纤维化。 含高密度细胞的薄片优选是完全可回收的，并且具有允许通过营养物和氧气的快速扩散维持最佳组织存活力的尺寸，并且还允许胰岛素和/或其它生物活性剂在分解速率方面的快速变化 改变生理学。 包含在生物人造植入物中的活细胞，组织，药物，药物和/或酶的植入物可以进行治疗和/或预防疾病。
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5.发明授权Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change, processes for their manufacture, and methods for their use 有权可回收的生物人造植入物具有允许氧的快速扩散和对生理变化的快速生物反应的尺寸，其制造方法及其使用方法
公开(公告)号：US6165225A
公开(公告)日：2000-12-26
申请号：US128188
申请日：1998-08-03
摘要： Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology. Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.
摘要翻译： 描述了生物人造植入物及其制造和使用的方法，特别是生物人造胰腺。 特别地，植入物可以是包围细胞的薄片，可以在延长的时间段内完全生物相容，并且可能不诱导纤维化。 含高密度细胞的薄片优选是完全可回收的，并且具有允许通过营养物和氧气的快速扩散维持最佳组织存活力的尺寸，并且还允许胰岛素和/或其它生物活性剂在分解速率方面的快速变化 改变生理学。 包含在生物人造植入物中的活细胞，组织，药物，药物和/或酶的植入物可以进行治疗和/或预防疾病。
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公开(公告)号：US06214338B1
公开(公告)日：2001-04-10
申请号：US09558080
申请日：2000-04-25
IPC分类号： A01N6300
CPC分类号： B01D67/0093 , A61L24/106 , A61M1/3693 , B01D61/18 , B01D63/16 , B01D2323/30 , B04B5/0442 , B04B2005/0478
摘要： A plasma concentrate comprising one of platelets and platelet releasate and from 5 to 400 mg/ml of fibrinogen. The concentrate further includes a physiologically acceptable carrier comprising water and physiologically acceptable inorganic and organic ions at a physiologically acceptable concentration. The fibrinogen in the concentrate is not significantly denatured. A method for processing blood is further provided.
摘要翻译： 一种血浆浓缩物，其包含血小板和血小板释放物之一和5至400mg / ml的纤维蛋白原。 浓缩物还包括生理上可接受的载体，其包含生理上可接受的浓度的水和生理上可接受的无机和有机离子。 浓缩物中的纤维蛋白原不显着变性。 还提供了一种处理血液的方法。
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公开(公告)号：US5814022A
公开(公告)日：1998-09-29
申请号：US595936
申请日：1996-02-06
CPC分类号： A61B17/00491 , A61B2017/00495 , A61M5/315 , B05C17/00516
摘要： A device and method for applying a fibrinogen-based tissue sealant to seamlessly connect human or animal tissues or organ parts, to seal wounds, stop bleeding and the like by mixing fibrin or fibrinogen with blood clot-promoting coagulation factors are disclosed. The device includes two cylindrical compartments for separately containing the separate fluid components of the sealant preparation, which are simultaneously displaced from the respective compartments by means of plungers commonly depressable with the same effective strokes. The plungers may be depressed directly or by means of a common mechanism (e.g., rack and pinion) for accurately controlling the rate of dispensing fluid. The cylindrical compartments are of the same or different cross-sectional area and are arranged either concentrically or side-by-side. The device further includes a means for merging the two fluid components within an outer sleeve housing an inner needle. The sleeve and needle contain conduits for the flow of the two fluid sealant components as they are expressed from the respective compartments. Also disclosed are a convenient means of filling the two compartments, a means for mixing the fluid components, and for atomizing the effluent sealant fluid stream (i.e., spraying).
摘要翻译： 公开了一种用于通过将纤维蛋白或纤维蛋白原与血块促进凝血因子混合来应用基于纤维蛋白原的组织密封剂来使人或动物组织或器官部分无缝连接以密封伤口，止血等的装置和方法。 该装置包括两个圆柱形隔室，用于分别容纳密封剂制剂的分开的流体组分，这些分离的流体组分通过通常可以用相同的有效冲程压下的柱塞从相应的隔间同时移位。 柱塞可以直接地或通过用于精确地控制分配流体速率的公共机构（例如，齿条和小齿轮）来压下。 圆柱形隔室具有相同或不同的横截面积，并且同心地或并排布置。 该装置还包括用于在容纳内针的外套筒内并入两个流体部件的装置。 套筒和针头包含用于两个流体密封剂组件的流动的导管，因为它们从相应的隔室表达。 还公开了填充两个隔室的方便手段，用于混合流体组分的装置和用于雾化流出物密封剂流体流（即，喷雾）。
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公开(公告)号：US5788662A
公开(公告)日：1998-08-04
申请号：US736862
申请日：1996-10-22
IPC分类号： A61K35/14 , A61L24/10 , A61M1/36 , B01D61/18 , B01D63/16 , B01D67/00 , B04B5/04 , C07K14/745 , A61K35/16 , B01D61/24
CPC分类号： B01D67/0093 , A61L24/106 , A61M1/3693 , A61M1/3696 , B01D61/18 , B01D63/16 , B04B5/0442 , B01D2323/30 , B04B2005/0478
摘要： An inexpensive device with a disposable cartridge for preparing tissue sealant is disclosed. The device is particularly applicable to stat preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate (from the device) with a solution of calcium and thrombin is also disclosed. Preparation in the operating room of 5 cc sealant from 50 cc patient blood requires less than 15 minutes and only one simple operator step. There is no risk of tracking error because processing can be done in the operating room. Chemicals added may be limited to anticoagulant (e.g., citrate) and calcium chloride. The disposable cartridge may fit in the palm of the hand and is hermetically sealed to eliminate possible exposure to patient blood and ensure sterility. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods. Antifibrinolytic agents (such as aprotinin) are not necessary because the tissue sealant contains high concentrations of natural inhibitors of fibrinolysis from the patient's blood. The tissue sealant also contains patient platelets and additional factors not present in available fibrin sealants that promote wound healing.
摘要翻译： 公开了一种具有用于制备组织密封剂的一次性盒的廉价装置。 该装置特别适用于自体组织密封胶的状态制备。 还公开了一种密封组织的方法，其中在将富含血小板的血浆浓缩物（来自该装置）与钙和凝血酶的溶液混合之后立即施加组织密封剂。 在手术室内从50cc患者血液制备5cc密封胶需要少于15分钟，只有一个简单的操作步骤。 没有跟踪错误的风险，因为可以在手术室进行处理。 加入的化学物质可能限于抗凝血剂（如柠檬酸盐）和氯化钙。 一次性药筒可以装配在手掌中并被密封，以消除患者血液的可能暴露并确保不育。 粘合剂和拉伸强度与用沉淀法制成的合并的血液纤维蛋白密封剂相当或优于其他。 抗纤维蛋白溶解剂（如抑肽酶）不是必需的，因为组织密封剂含有高浓度的患者血液中的纤维蛋白溶解天然抑制剂。 组织密封剂还含有患者血小板和不存在于促进伤口愈合的可用纤维蛋白密封剂中的另外的因素。
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9.发明授权Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant 失效用于制备浓缩等离子体和/或组织密封剂的等离子体浓缩物和组织密封剂方法和装置
公开(公告)号：US5585007A
公开(公告)日：1996-12-17
申请号：US351010
申请日：1994-12-07
IPC分类号： A61K35/14 , A61L24/10 , A61M1/36 , B01D61/18 , B01D63/16 , B01D67/00 , B04B5/04 , C07K14/745 , B01D33/15 , A61K35/16 , A61M1/14 , B01D33/27
CPC分类号： B01D67/0093 , A61L24/106 , A61M1/3693 , A61M1/3696 , B01D61/18 , B01D63/16 , B04B5/0442 , B01D2323/30 , B04B2005/0478
摘要： An inexpensive device with a disposable cartridge for preparing tissue sealant is disclosed. The device is particularly applicable to star preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate (from the device) with a solution of calcium and thrombin is also disclosed. Preparation in the operating room of 5 cc sealant from 50 cc patient blood requires less than 15 minutes and only one simple operator step. There is no risk of tracking error because processing can be done in the operating room. Chemicals added may be limited to anticoagulant (e.g., citrate) and calcium chloride. The disposable cartridge may fit in the palm of the hand and is hermetically sealed to eliminate possible exposure to patient blood and ensure sterility. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods. Antifibrinolytic agents (such as aprotinin) are not necessary because the tissue sealant contains high concentrations of natural inhibitors of fibrinolysis from the patient's blood. The tissue sealant also contains patient platelets and additional factors not present in available fibrin sealants that promote wound healing.
摘要翻译： 公开了一种具有用于制备组织密封剂的一次性盒的廉价装置。 该装置特别适用于自体组织密封剂的星形制剂。 还公开了一种密封组织的方法，其中在将富含血小板的血浆浓缩物（来自该装置）与钙和凝血酶的溶液混合之后立即施加组织密封剂。 在手术室内从50cc患者血液制备5cc密封胶需要少于15分钟，只有一个简单的操作步骤。 没有跟踪错误的风险，因为可以在手术室进行处理。 加入的化学物质可能限于抗凝血剂（如柠檬酸盐）和氯化钙。 一次性药筒可以装配在手掌中并被密封，以消除患者血液的可能暴露并确保不育。 粘合剂和拉伸强度与用沉淀法制成的合并的血液纤维蛋白密封剂相当或优于其他。 抗纤维蛋白溶解剂（如抑肽酶）不是必需的，因为组织密封剂含有高浓度的患者血液中的纤维蛋白溶解天然抑制剂。 组织密封剂还含有患者血小板和不存在于促进伤口愈合的可用纤维蛋白密封剂中的另外的因素。
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公开(公告)号：US08596470B2
公开(公告)日：2013-12-03
申请号：US13400188
申请日：2012-02-20
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator system operable to use centrifugation to fractionate a multiple component material, such as a suspension including blood, comprises a buoy. The buoy can be carried in a separation container and has a tuned density that is configured to reach an equilibrium position in the multiple component material. A guide surface is carried on a buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
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