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公开(公告)号:US20050090448A1
公开(公告)日:2005-04-28
申请号:US10937912
申请日:2004-09-10
申请人: Richard Johnson , Shelley Maves
发明人: Richard Johnson , Shelley Maves
CPC分类号: C07K14/472
摘要: The present invention relates to compositions, including pharmaceutical compositions that inhibit complement activation, and contain amino acid sequences X1-X2-X3-W-E-X4-X5-X6 and/or Z1-C1-Z2-P-Z3-Z4-C2-Z5 as described. The invention further relates to methods of inhibiting complement activation in vivo or ex vivo by administering a pharmaceutical composition as described herein.
摘要翻译: 本发明涉及组合物,包括抑制补体活化的药物组合物,并含有氨基酸序列X 1 -X 2 -X 3 - 5×6×6×6和/或Z 1 -C 1 SUB > -Z 2 -ZZ 3 -Z 4 -Z 2 -Z 5 >如所述。 本发明还涉及通过施用如本文所述的药物组合物来抑制体内或体外补体活化的方法。
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公开(公告)号:US20050090447A1
公开(公告)日:2005-04-28
申请号:US10938088
申请日:2004-09-10
申请人: Richard Johnson , Shelley Maves
发明人: Richard Johnson , Shelley Maves
IPC分类号: A61K38/08 , A61K47/48 , A61L15/32 , A61L26/00 , A61L29/00 , A61P37/04 , C07K14/47 , C07K7/06
CPC分类号: A61L26/0047 , A61K38/08 , A61K47/64 , A61L15/32 , C07K14/472
摘要: The present invention relates to compositions, including pharmaceutical compositions that promote complement activation, and contain a polypeptide X1-C-X2-X3-X4-X5-X6-X7-X8-C-X9 as described. The invention further relates to a method of promoting complement activation in a patient by administering a pharmaceutical composition as described herein. Further provided are a wound dressing and an anti-tumor cell antigen antibody formulation containing pharmaceutical compositions of the present invention.
摘要翻译: 本发明涉及组合物,包括促进补体活化的药物组合物,并且含有多肽X 1 -CX 2 -X 3 -X 4→5→5→6→-X 7→-X 8 -CX 如上所述。 本发明还涉及通过施用本文所述的药物组合物促进患者补体活化的方法。 还提供了包含本发明的药物组合物的伤口敷料和抗肿瘤细胞抗原抗体制剂。
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