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公开(公告)号：US20100234305A1
公开(公告)日：2010-09-16
申请号：US12784343
申请日：2010-05-20
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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公开(公告)号：US06773714B2
公开(公告)日：2004-08-10
申请号：US10373400
申请日：2003-02-24
IPC分类号： A61K900
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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3.发明申请公开(公告)号：US20100226954A1
公开(公告)日：2010-09-09
申请号：US12784304
申请日：2010-05-20
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
摘要翻译： 本发明涉及适合用作控释植入物的可流动组合物。 可流动组合物包括至少基本上不溶于水性介质或体液的可生物降解的热塑性聚酯。 可流动组合物还包括生物相容的极性非质子溶剂。 生物相容的极性非质子溶剂可混溶于水性介质或体液中。 可流动组合物还包括醋酸亮丙瑞林。
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公开(公告)号：US06565874B1
公开(公告)日：2003-05-20
申请号：US09711758
申请日：2000-11-13
IPC分类号： A61F200
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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公开(公告)号：US09254307B2
公开(公告)日：2016-02-09
申请号：US12784343
申请日：2010-05-20
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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公开(公告)号：US08486455B2
公开(公告)日：2013-07-16
申请号：US12784304
申请日：2010-05-20
IPC分类号： A61K9/08
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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