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公开(公告)号：US20100234305A1
公开(公告)日：2010-09-16
申请号：US12784343
申请日：2010-05-20
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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公开(公告)号：US06773714B2
公开(公告)日：2004-08-10
申请号：US10373400
申请日：2003-02-24
IPC分类号： A61K900
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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3.发明申请公开(公告)号：US20100226954A1
公开(公告)日：2010-09-09
申请号：US12784304
申请日：2010-05-20
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
摘要翻译： 本发明涉及适合用作控释植入物的可流动组合物。 可流动组合物包括至少基本上不溶于水性介质或体液的可生物降解的热塑性聚酯。 可流动组合物还包括生物相容的极性非质子溶剂。 生物相容的极性非质子溶剂可混溶于水性介质或体液中。 可流动组合物还包括醋酸亮丙瑞林。
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公开(公告)号：US06565874B1
公开(公告)日：2003-05-20
申请号：US09711758
申请日：2000-11-13
IPC分类号： A61F200
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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公开(公告)号：US09254307B2
公开(公告)日：2016-02-09
申请号：US12784343
申请日：2010-05-20
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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公开(公告)号：US08486455B2
公开(公告)日：2013-07-16
申请号：US12784304
申请日：2010-05-20
IPC分类号： A61K9/08
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
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公开(公告)号：US06261583B1
公开(公告)日：2001-07-17
申请号：US09123723
申请日：1998-07-28
IPC分类号： A61K31765
CPC分类号： A61K9/0024
摘要： The invention provides an implant composition for sustained delivery of a biologically active agent. The implant composition includes a biologically active agent, a thermoplastic polymer, an organic liquid and a small amount of an aqueous medium. The thermoplastic polymer is insoluble in water so that the implant composition has the form of a substantially homogeneous pliable, moldable solid.
摘要翻译： 本发明提供用于持续递送生物活性剂的植入物组合物。 植入物组合物包括生物活性剂，热塑性聚合物，有机液体和少量水性介质。 热塑性聚合物不溶于水，使得植入物组合物具有基本均匀的柔软的可模制固体的形式。
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8.发明授权Controlled release liquid delivery compositions with low initial drug burst 有权具有低初始药物爆发的控制释放液体递送组合物公开(公告)号：US06630155B1
公开(公告)日：2003-10-07
申请号：US09643289
申请日：2000-08-22
IPC分类号： A61F200
CPC分类号： A61K9/0024
摘要： The invention provides a controlled release polymeric composition which includes a base polymer or copolymer, an organic solvent, a polymeric controlled release additive, and a biologically active agent. The polymeric controlled release additive reduces the initial burst of biologically active agent released from the polymeric composition as it is solidifying to form the solid implant. The controlled release additive is preferably a poly(lactide-co-glycolide)/polyethylene glycol block copolymer.
摘要翻译： 本发明提供一种控释聚合物组合物，其包含基础聚合物或共聚物，有机溶剂，聚合物控释添加剂和生物活性剂。 当聚合物组合物固化以形成固体植入物时，聚合物控制释放添加剂减少从聚合物组合物释放的生物活性剂的初始爆发。 控释添加剂优选为聚（丙交酯 - 共 - 乙交酯）/聚乙二醇嵌段共聚物。
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公开(公告)号：US6143314A
公开(公告)日：2000-11-07
申请号：US181355
申请日：1998-10-28
IPC分类号： A61K47/30 , A61K9/00 , A61K9/08 , A61K31/167 , A61K31/706 , A61K45/00 , A61F2/00
CPC分类号： A61K9/0024
摘要： The invention provides a controlled release polymeric composition which includes a base polymer or copolymer, an organic solvent, a polymeric controlled release additive, and a biologically active agent. The polymeric controlled release additive reduces the initial burst of biologically active agent released from the polymeric composition as it is solidifying to form the solid implant. The controlled release additive is preferably a poly(lactide-co-glycolide)/polyethylene glycol block copolymer.
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10.发明授权公开(公告)号：US08017144B2
公开(公告)日：2011-09-13
申请号：US12257803
申请日：2008-10-24
申请人： Francis Dumont , Richard L. Dunn , Scott A. Jeffers , Richard W. Korsmeyer , Mei Li , Vishwas M. Paralkar , Mingxing Zhou
发明人： Francis Dumont , Richard L. Dunn , Scott A. Jeffers , Richard W. Korsmeyer , Mei Li , Vishwas M. Paralkar , Mingxing Zhou
IPC分类号： A61F2/02
CPC分类号： A61K9/0024 , A61K31/20 , A61K31/44
摘要： The present invention is directed to an improved system for controlled release of a bone growth promoting compound and to a flowable composition for its formation. The flowable composition is composed of a bone growth promoting compound, a thermoplastic polymer and an organic solvent. The flowable composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of a bone growth promoting compound to certain tissues.
摘要翻译： 本发明涉及一种用于骨生长促进化合物和用于其形成的可流动组合物的控制释放的改进系统。 可流动组合物由骨生长促进化合物，热塑性聚合物和有机溶剂组成。 可流动组合物能够形成可生物降解和/或生物腐蚀性微孔固体聚合物基质。 该基质可用作用于将骨生长促进化合物递送至某些组织的患者（人和动物）中的植入物。
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