公开(公告)号：US4863442A

公开(公告)日：1989-09-05

申请号：US85392

申请日：1987-08-14

申请人： Richard M. DeMello ,  Robert J. Ham ,  Michael Lang ,  Gerry D. Ouellette ,  Andrea T. Slater ,  Frederick W. Trombley, III

发明人： Richard M. DeMello ,  Robert J. Ham ,  Michael Lang ,  Gerry D. Ouellette ,  Andrea T. Slater ,  Frederick W. Trombley, III

IPC分类号： A61M25/08 ,  A61L29/04 ,  A61L29/08 ,  A61M25/00 ,  B29C41/14 ,  B29C41/20 ,  B29C57/00 ,  B29C65/02 ,  B29C70/76

CPC分类号： A61M25/001 ,  A61L29/041 ,  A61L29/085 ,  A61M25/0069 ,  A61M25/008 ,  B29C41/20 ,  B29C57/00 ,  B29C65/02 ,  B29C66/5344 ,  B29C70/76 ,  A61M2025/0081 ,  A61M25/0012 ,  A61M25/005 ,  A61M25/0108 ,  B29C2793/0081 ,  B29C41/14 ,  B29C66/71 ,  B29L2031/7542

摘要： A guide catheter having a tubular body with a wire-braided Teflon core and a polyurethane jacket. The distal end of the jacket is removed from the core, and a soft polyurethane tip is applied to the core over the region where the jacket has been removed. The tip overlaps the core for approximately two millimeters and extends distally approximately two millimeters beyond the distal end of the core. The tip may be applied to the core as a separate tube bonded to it or be built up on the core by repeatedly dipping the top in a polyurethane slurry, or be molded onto the distal end of the core.

公开(公告)号：US08961435B2

公开(公告)日：2015-02-24

申请号：US13586236

申请日：2012-08-15

申请人： Richard M. DeMello

发明人： Richard M. DeMello

IPC分类号： A61M25/09

CPC分类号： A61M25/09 ,  A61M2025/09083

摘要： A coaxial guidewire for use in accessing smaller vessels within a patient's body, consists of an inner core wire and an outer hollow wire. The distal end of the inner core wire tapers and supports a spring coil. The core wire, including the spring coil, fits within a 25-gauge needle that is used to locate an artery of the patient. When the needle is removed over the inner core wire, the outer hollow wire, having a distal end that tapers to the outer diameter of the spring coil, fits over the inner wire and is advanced until the distal end of the outer wire meets the spring coil of the core wire. A dilator and introducer sheath combination may then be fed over the assembled coaxial guidewire. When the distal end of the sheath is in the desired position, the dilator and the coaxial guidewire are removed.

摘要翻译： 用于访问患者体内的较小容器的同轴导丝由内芯线和外部中空线组成。 内芯线的远端锥形并支撑弹簧线圈。 包括弹簧线圈的芯线安装在用于定位患者动脉的25号针中。 当针在内芯线上移除时，具有与弹簧线圈的外径成锥形的远端的外部中空线装配在内部线材上并且前进直到外部线缆的远端与弹簧 线芯线芯。 然后可以在组装的同轴导丝上进给扩张器和导引器鞘组合。 当鞘的远端处于所需位置时，扩张器和同轴导丝被移除。

公开(公告)号：US06695836B1

公开(公告)日：2004-02-24

申请号：US09609410

申请日：2000-07-03

申请人： Richard M. DeMello ,  Maureen A. Finlayson

发明人： Richard M. DeMello ,  Maureen A. Finlayson

IPC分类号： A61B1804

CPC分类号： A61B18/1492 ,  A61B2017/00092 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61B2018/1435 ,  A61B2090/036 ,  A61B2218/002

摘要： A device and method for treating tissue at a treatment site. The device and method include supplying controlled energy to a heating portion of the device positioned within a tissue wall at the treatment site. The size of the heating portion and energy supplied provides for ablation of the tissue to form a cavity within the tissue wall without ablating the surfaces of the tissue wall. Treatment fluid can then be supplied through the device to the cavity to supplement growth of blood vessels or retard such growth at the treatment site. The device can also be used to create an injury zone at a treatment site without ablating tissue, wherein the injury zone can be injected with treatment fluid. The device and method has use anywhere within the body, especially in the regions of the heart.

摘要翻译： 用于治疗部位处理组织的装置和方法。 该装置和方法包括将受控的能量提供给位于治疗部位的组织壁内的装置的加热部分。 加热部分的尺寸和供应的能量提供组织的消融以在组织壁内形成空腔，而不会烧蚀组织壁的表面。 然后可以将处理液通过装置供应到空腔以补充血管的生长或在治疗部位延缓这种生长。 该装置还可用于在治疗部位创建损伤区，而不会烧伤组织，其中可以用治疗液注射损伤区域。 该装置和方法已经在身体内的任何地方使用，特别是在心脏的区域中。

公开(公告)号：US20100131000A1

公开(公告)日：2010-05-27

申请号：US12275822

申请日：2008-11-21

申请人： Richard M. DeMello ,  Jonathan R. DeMello ,  Richard R. Heuser ,  Maureen A. Finlayson

发明人： Richard M. DeMello ,  Jonathan R. DeMello ,  Richard R. Heuser ,  Maureen A. Finlayson

IPC分类号： A61B17/221

CPC分类号： A61B17/221 ,  A61B2017/00367 ,  A61B2017/2215 ,  Y10T29/49826

摘要： This invention provides a device and controllably expansive tool tip for thrombus removal. According to one embodiment, the controllably expansive thrombus removal tool tip (e.g., a screen and/or mesh) may be collapsed by pushing on an actuating handle, and then advanced into a balloon or guiding catheter until a distal end of device has reached the thrombus. The tool tip is then expanded by pulling the actuating handle backward; and the radially extended (expanded) tool tip is moved to receive and substantially surround (e.g., encompass) the thrombus. The tool tip may then be collapsed again by pushing on the actuating handle to engage (tighten around) the thrombus, and the device may be withdrawn from a patient's body through the vascular system with the thrombus engaged by the tool tip.

摘要翻译： 本发明提供了用于血栓去除的装置和可控制的膨胀工具尖端。 根据一个实施例，可控膨胀的血栓去除工具尖端（例如，筛网和/或网孔）可以通过推动致动手柄而折叠，然后前进到气囊或引导导管中，直到装置的远端到达 血栓。 然后通过向后拉动致动手柄来扩大工具尖端; 并且径向延伸（扩大）的工具尖端被移动以接收和基本上围绕（例如，包围）血栓。 然后可以通过推动致动手柄使工具尖端折叠以接合（紧固）血栓，并且可以通过血管系统将装置从患者的身体抽出，其中血栓由工具尖端接合。

公开(公告)号：US5460187A

公开(公告)日：1995-10-24

申请号：US270034

申请日：1994-07-01

申请人： James B. Daigle ,  Richard M. DeMello ,  Bruce W. Flight

发明人： James B. Daigle ,  Richard M. DeMello ,  Bruce W. Flight

IPC分类号： A61M25/00 ,  A61B5/00 ,  A61M25/01 ,  A61M25/09

CPC分类号： A61M25/09 ,  A61M2025/09166 ,  A61M2025/09175

摘要： A guidewire adapted to be inserted into a vascular vessel or into a catheter that is to be inserted into a vascular vessel or the like. The guidewire comprises a coil of flexible radiotransparent wire having a proximal section and a distal section. The proximal section is formed of a coil of wire having abutting turns and distal section is formed by the same coil of wire with the turns of wire being spaced from each other. A layer of radiopaque material of predetermined length is disposed in a predetermined location on the distal section, the interior of the layer being interstitially disposed within the outer surface of the coil. A hemispherical tip is disposed at the distal end of the distal section. A small braze is made at the juncture between the proximal section and the distal section to prevent spreading of the coils from the abutting relationship in the proximal end of said guidewire.

摘要翻译： 一种适于插入血管容器或插入血管容器等的导管中的导丝。 导线包括具有近端部分和远端部分的柔性无线电透射线圈。 近侧部分由具有邻接匝的线圈形成，并且远端部分由相同的线圈线形成，线的匝彼此间隔开。 具有预定长度的不透射线材料层设置在远端部分上的预定位置，该层的内部间隙地设置在线圈的外表面内。 半球形尖端设置在远端部分的远端。 在近端部分和远端部分之间的接合部处形成小的铜焊，以防止线圈从所述导丝的近端处的邻接关系扩散。

公开(公告)号：US5253653A

公开(公告)日：1993-10-19

申请号：US786061

申请日：1991-10-31

申请人： James B. Daigle ,  Richard M. DeMello ,  Bruce W. Flight

发明人： James B. Daigle ,  Richard M. DeMello ,  Bruce W. Flight

IPC分类号： A61M25/00 ,  A61B5/00 ,  A61M25/01 ,  A61M25/09 ,  A61M25/095

CPC分类号： A61M25/09 ,  A61M2025/09091 ,  A61M2025/09175 ,  A61M25/0108

摘要： A guidewire assembly for measuring the size of occlusions in blood vessels which includes a guidewire having a flexible, distal end disposable in a blood vessel. The guidewire has a core wire disposed within it which extends to the distal tip. A linear array of radiopaque markers is disposed adjacent the distal tip of the core wire. The markers are spaced from each other at predetermined distances, whereby to enable the user to accurately measure the size and diameter of occlusions in blood vessels using radiological techniques.

摘要翻译： 一种用于测量血管中的闭塞尺寸的导丝组件，其包括具有在血管中一次性的柔性远端的导丝。 导线具有设置在其内的芯线，其延伸到远侧末端。 不透射线标记的线性阵列设置在芯线的远端附近。 标记物以预定距离彼此间隔开，从而使得使用者能够使用放射技术精确地测量血管中的闭塞的尺寸和直径。

公开(公告)号：US20130046203A1

公开(公告)日：2013-02-21

申请号：US13586236

申请日：2012-08-15

申请人： Richard M. DeMello

发明人： Richard M. DeMello

IPC分类号： A61M25/09

CPC分类号： A61M25/09 ,  A61M2025/09083

摘要： A coaxial guidewire for use in accessing smaller vessels within a patient's body, consists of an inner core wire and an outer hollow wire. The distal end of the inner core wire tapers and supports a spring coil. The core wire, including the spring coil, fits within a 25-gauge needle that is used to locate an artery of the patient. When the needle is removed over the inner core wire, the outer hollow wire, having a distal end that tapers to the outer diameter of the spring coil, fits over the inner wire and is advanced until the distal end of the outer wire meets the spring coil of the core wire. A dilator and introducer sheath combination may then be fed over the assembled coaxial guidewire. When the distal end of the sheath is in the desired position, the dilator and the coaxial guidewire are removed.

摘要翻译： 用于访问患者体内的较小容器的同轴导丝由内芯线和外部中空线组成。 内芯线的远端锥形并支撑弹簧线圈。 包括弹簧线圈的芯线安装在用于定位患者动脉的25号针中。 当针在内芯线上移除时，具有与弹簧线圈的外径成锥形的远端的外部中空线装配在内部线材上并且前进直到外部线缆的远端与弹簧 线芯线芯。 然后可以在组装的同轴导丝上进给扩张器和导引器鞘组合。 当鞘的远端处于所需位置时，扩张器和同轴导丝被移除。

公开(公告)号：US20080228209A1

公开(公告)日：2008-09-18

申请号：US12098201

申请日：2008-04-04

申请人： Richard M. DeMello ,  Jonathan R. DeMello ,  Richard R. Heuser ,  Maureen A. Finlayson ,  Jon Burkhardt ,  Craig Parker

发明人： Richard M. DeMello ,  Jonathan R. DeMello ,  Richard R. Heuser ,  Maureen A. Finlayson ,  Jon Burkhardt ,  Craig Parker

IPC分类号： A61B17/22

CPC分类号： A61B17/32056 ,  A61B17/221 ,  A61B2017/00867 ,  A61B2017/22034 ,  A61B2017/22035 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/2217

摘要： This invention provides a small diameter snare device and device for thrombus removal consisting of a hollow, elongate, thin-walled outer sheath. A single central core wire extends through the entire length of the sheath. The outer diameter of the core wire is sized close to the inner diameter of the sheath while allowing for axial sliding, in order to maximize the support to the body portion of the snare device. A tool tip or “capture segment” at the distal end of the sheath and core wire can be controllably expanded to engage a thrombus and remove the thrombus from the blood vessel.

摘要翻译： 本发明提供了一种用于血栓消除的小直径圈套装置和装置，其包括中空的，细长的薄壁外护套。 单个中心芯线延伸穿过护套的整个长度。 芯线的外径尺寸接近护套的内径，同时允许轴向滑动，以便最大限度地提供对圈套装置的主体部分的支撑。 护套和芯线的远端处的工具尖端或“捕获段”可以可控地扩张以接合血栓并从血管中移除血栓。

公开(公告)号：US06554842B2

公开(公告)日：2003-04-29

申请号：US09803308

申请日：2001-03-09

申请人： Richard R. Heuser ,  Richard M. DeMello

发明人： Richard R. Heuser ,  Richard M. DeMello

IPC分类号： A61F1100

CPC分类号： A61B17/32056 ,  A61B17/221 ,  A61B90/39 ,  A61B2017/2212 ,  A61B2090/3954

摘要： A small-diameter surgical snare device that is capable of fitting through existing balloon or guiding catheters includes metal tubing along a section of a core wire. The distal end of the core wire connects to one or more snare wires that form the snaring loop. The distal end of the snaring loop supports a radiopaque coil or collar that makes the end of the loop visible under fluoroscopy. The snaring loop may consist of one or two wires or an overlap of a tapered end of the core wire. A radiopaque coil is attached to a distal end of the metal tubing, to provide flexibility and visibility to a distal region of the device. Alternatively, a polyimide tube and a short radiopaque marker may be included at a distal end of the metal tubing. The polyimide tube fits inside of the metal tubing, to add strength and torsion control to the distal region of the device, while the radiopaque marker adds visibility. In all embodiments, a shrink tube is fit over the radiopaque coil or marker that is supported by the distal end of the metal tubing, to ensure that the coil does not stretch when the snaring loop is extended during use.

摘要翻译： 能够通过现有气囊或引导导管装配的小口径手术圈套装置包括沿芯线部分的金属管。 芯线的远端连接到形成缠绕环的一个或多个圈套线。 缠绕环的远端支持不透射线圈或环，使得环的末端在荧光透视下可见。 缠绕环可以由一条或两条线或芯线的锥形端的重叠组成。 不透射线圈附接到金属管的远端，以向装置的远侧区域提供灵活性和可见性。 或者，可以在金属管的远端包括聚酰亚胺管和短的不透射线的标记。 聚酰亚胺管装配在金属管道的内部，以增加设备远端区域的强度和扭力控制，而不透射线的标记增加了可视性。 在所有实施例中，收缩管装配在由金属管的远端支撑的不透射线圈或标记上，以确保线圈在使用期间在缠绕环延伸时不拉伸。

公开(公告)号：US06544197B2

公开(公告)日：2003-04-08

申请号：US09778566

申请日：2001-02-07

申请人： Richard M. DeMello

发明人： Richard M. DeMello

IPC分类号： A61B500

CPC分类号： A61M25/09 ,  A61M25/09033 ,  A61M2025/09083 ,  A61M2025/09091 ,  A61M2025/09141

摘要： A composite guidewire includes a solid central core of super elastic material and one or more core overlays of non-super elastic material. A coupling tube fits over the proximal end of the core, and a coil, which may be radiopaque, fits over the distal end of the core and attaches to a distal end of the coupling tube. A flat safety wire that is positioned between the distal portion of the coupling tube and the core also attaches to the distal end of the tube. The safety wire extends the length of the coil and attaches to both the distal and the proximal ends of the coil. The guidewire's proximal end may be a non-super elastic core extension shaped at its distal end to overlap and mechanically inter-lock with a proximal end of the core and the coil and safety wire may extend beyond the distal end of the core.

摘要翻译： 复合导丝包括超弹性材料的实心中心芯和非超弹性材料的一个或多个芯覆层。 耦合管装配在芯的近端上，并且可以是不透射线的线圈装配在芯的远端上并且附接到耦合管的远端。 位于联接管的远端部分和芯之间的扁平安全线也附接到管的远端。 安全线延伸线圈的长度并且连接到线圈的远端和近端两端。 导丝的近端可以是在其远端处成形的非超弹性芯延伸部，以与芯的近端重叠并机械地相互锁定，并且线圈和安全线可以延伸超过芯的远端。