专利检索 ap:("Richard Martin Jacobson" OR "Mark Joseph Mulvihill" OR "Changling Liu" OR "Xiaonan Liu") AND inv:"Mark Joseph Mulvihill" 第 1 页

1.

发明授权
Substituted triazoles imidazoles and pyrazoles as herbicides 失效
标题翻译：取代的三唑咪唑和吡唑作为除草剂

公开(公告)号：US06258751B1

公开(公告)日：2001-07-10

申请号：US09593096

申请日：2000-06-13

申请人： Richard Martin Jacobson , Mark Joseph Mulvihill , Changling Liu , Xiaonan Liu

发明人： Richard Martin Jacobson , Mark Joseph Mulvihill , Changling Liu , Xiaonan Liu

IPC分类号： A01N43653

CPC分类号： C07D231/12 , A01N43/653 , C07D233/56 , C07D249/08

摘要： The present invention relates to novel heterocyclic compounds and their agronomically suitable salts, methods for the use of these compounds in controlling unwanted plant species, and the use of herbicidal compositions containing these compounds. In particular, the present invention pertains to substituted and unsubstituted triazoles, imidazoles and pyrazoles linked to a heterocyclic substituted benzene group. Such compounds are useful as pre-emergent and post-emergent herbicides.

摘要翻译： 本发明涉及新的杂环化合物及其农艺学上适用的盐，这些化合物在控制不想要的植物物种中的应用方法，以及含有这些化合物的除草组合物的用途。特别地，本发明涉及与杂环取代的苯基连接的取代和未取代的三唑，咪唑和吡唑。这些化合物可用作芽前和芽后除草剂。

2.

发明申请
6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors 失效
标题翻译： 6,6-双环取代杂双环蛋白激酶抑制剂

公开(公告)号：US20120077979A1

公开(公告)日：2012-03-29

申请号：US13308694

申请日：2011-12-01

申请人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun

发明人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun

IPC分类号： C07D487/04 , C07F5/02

CPC分类号： C07F5/025 , C07D471/04 , C07D487/04

摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

摘要翻译： 其中X 1，X 2，X 3，X 4，X 5，X 6，X 7，R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶，并且可用于治疗和/或预防过度增生性疾病如癌症，炎症，牛皮癣，过敏/哮喘，免疫系统的疾病和状况，中枢神经系统的疾病和状况。

3.

发明授权
Fused bicyclic mTOR inhibitors 有权
标题翻译：融合双环mTOR抑制剂

公开(公告)号：US07700594B2

公开(公告)日：2010-04-20

申请号：US11599663

申请日：2006-11-15

申请人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard

发明人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard

IPC分类号： C07D487/04 , C07D401/14 , C07D403/04 , A61K31/53 , A61K31/4523 , A61K35/00

CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14

摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。

4.

发明申请
6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors 有权

公开(公告)号：US20090118499A1

公开(公告)日：2009-05-07

申请号：US12244947

申请日：2008-10-03

申请人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun

发明人： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun

IPC分类号： C07D487/04

CPC分类号： C07F5/025 , C07D471/04 , C07D487/04

摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

5.

发明授权
Fused bicyclic mTOR inhibitors 有权
标题翻译：融合双环mTOR抑制剂

公开(公告)号：US08796455B2

公开(公告)日：2014-08-05

申请号：US13767947

申请日：2013-02-15

申请人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard

发明人： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard

IPC分类号： C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/5025 , A61P19/02 , A61P35/00

CPC分类号： C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14

摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.

摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。

6.

发明授权
Imidazotriazines as protein kinase inhibitors 失效
标题翻译：咪唑三嗪作为蛋白激酶抑制剂

公开(公告)号：US07741324B2

公开(公告)日：2010-06-22

申请号：US11185599

申请日：2005-07-20

申请人： Andrew Philip Crew , Mark Joseph Mulvihill , Douglas Scott Werner

发明人： Andrew Philip Crew , Mark Joseph Mulvihill , Douglas Scott Werner

IPC分类号： C07D487/04 , C07D487/12 , A61K31/53 , A61K35/00

CPC分类号： C07D487/04

摘要： Compounds of the formula and pharmaceuticaly acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.

摘要翻译： 其中Q1和R1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶，并且可用于治疗和/或预防通过抑制酪氨酸激酶对治疗作出反应的各种疾病和病症。

7.

发明授权
Substituted thienol[2,3-d]pyrimidines as kinase inhibitors 失效
标题翻译：取代的噻吩并[2,3-d]嘧啶作为激酶抑制剂

公开(公告)号：US07566721B2

公开(公告)日：2009-07-28

申请号：US11498975

申请日：2006-08-03

申请人： Qun-Sheng Ji , Mark Joseph Mulvihill , Arno G. Steinig , Qinghua Weng

发明人： Qun-Sheng Ji , Mark Joseph Mulvihill , Arno G. Steinig , Qinghua Weng

IPC分类号： A61K31/519 , C07D495/04 , A61P35/04 , A61P31/22 , A61P11/06 , A61P19/02

CPC分类号： C07D495/04

摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

摘要翻译： 其中X 1，X 2，X 3和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶，并且可用于治疗和/或预防过度增殖性疾病如癌症，炎症，牛皮癣，过敏/哮喘，免疫系统的疾病和状况，中枢神经系统的疾病和状况。