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    Cationic substituted benzofurans as antimicrobial agents
    1.
    发明申请
    Cationic substituted benzofurans as antimicrobial agents 审中-公开
    阳离子取代的苯并呋喃作为抗微生物剂

    公开(公告)号：US20080221191A1

    公开(公告)日：2008-09-11

    申请号：US11982229

    申请日：2007-10-31

    申请人： Richard R. Tidwell ,  Karl Werbovetz ,  Scott Gary Franzblau ,  Svetlana Bakunova ,  Stanislav Bakunov

    发明人： Richard R. Tidwell ,  Karl Werbovetz ,  Scott Gary Franzblau ,  Svetlana Bakunova ,  Stanislav Bakunov

    IPC分类号： A61K31/4178 ,  C07D307/78 ,  A61K31/343 ,  C07D407/02 ,  A61P31/04

    CPC分类号： C07D307/80

    摘要： A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense, a Trypanosoma cruzi, and Plasmodium falciparum, and fungal pathogens, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.

    摘要翻译： 一种通过向受试者施用有效量的阳离子取代的苯并呋喃化合物来治疗有需要的受试者的结核分枝杆菌感染的方法。 治疗微生物感染的方法，包括原生动物病原体的感染，例如杜氏利什曼原虫，罗非鱼锥虫，克氏锥虫和恶性疟原虫，以及真菌病原体，例如白色念珠菌，烟曲霉和新型隐球酵母，需要的受试者 其通过向受试者施用有效量的阳离子取代的苯并呋喃化合物。 合成新型阳离子取代苯并呋喃化合物和新化合物本身的方法。

    Process for the synthesis of bis-aryl diamidoxime compounds
    10.
    发明授权
    Process for the synthesis of bis-aryl diamidoxime compounds 失效
    双芳基二肟化合物的合成方法

    公开(公告)号：US07071338B2

    公开(公告)日：2006-07-04

    申请号：US10722085

    申请日：2003-11-25

    申请人： David W. Boykin ,  Mariappan Anbazhagan ,  Richard R. Tidwell

    发明人： David W. Boykin ,  Mariappan Anbazhagan ,  Richard R. Tidwell

    IPC分类号： C07D207/335 ,  C07D307/52 ,  C07D333/22

    CPC分类号： C07D307/54

    摘要： Bis-aryl diamidoxime compounds, such as 2,5-bis [4-hydroxy and 4-O-alkylamidinophenyl] furans, can be prepared from 2,5-bis tri-alkylstannanes via a one step palladium-catalyzed cross reaction. Bis-aryl diamidoxime compounds, such as 2,5-bis [4-hydroxy and 4-O-alkylamidinophenyl]furans, are useful as therapeutic compounds. The disclosed process is scalable, simpler, more economic and more feasible than other presently known methods of preparing 2,5-bis [4-hydroxy and 4-O-alkylamidinophenyl]furans and other bis-aryl diamidoxime compounds.

    摘要翻译： 双芳基二肟化合物，如2,5-双[4-羟基和4-O-烷基脒基苯基]呋喃，可以通过一步钯催化的交叉反应由2,5-双三烷基锡烷制备。 双芳基二肟化合物，例如2,5-双[4-羟基和4-O-烷基脒基苯基]呋喃，可用作治疗化合物。 所公开的方法比其它目前已知的制备2,5-双[4-羟基和4-O-烷基脒基苯基]呋喃和其它双芳基二肟基化合物的方法是可扩展的，更简单的，更经济的和更可行的。