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    Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents
    8.
    发明授权
    Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents 失效

    公开(公告)号：US07256203B2

    公开(公告)日：2007-08-14

    申请号：US10721525

    申请日：2003-11-25

    申请人： David W. Boykin ,  Richard R. Tidwell ,  Mohamed A. Ismail ,  Reto Brun

    发明人： David W. Boykin ,  Richard R. Tidwell ,  Mohamed A. Ismail ,  Reto Brun

    IPC分类号： A61K31/44 ,  C07D401/02

    CPC分类号： C07D307/38 ,  C07D307/54 ,  C07D333/08 ,  C07D405/04 ,  C07D405/14 ,  C07D407/04 ,  C07D407/14 ,  C07D409/04 ,  C07D409/14

    摘要： A compound of Formula (I): wherein: X is selected from the group consisting of O, S, and NR17, where R17 is hydrogen or lower alkyl; A and Y are CH, N, NR17, O, or S; C1 and C2 are each C or N, wherein C1 and C2 are the same or different; D1 and D2 are each C or N, wherein D1 and D2 are the same or different; B and Z are CH, N, or NR17, provided that B, Z, or both B and Z are not present when A, Y, or both A and Y are O, S, or NR17; R13, R14, R1 and R8 can be present or absent, and when present are selected from the group consisting of H, lower alkyl, halogen, alkoxyl, aryloxyl, aralkoxy and hydroxyl; R15 and Rare selected from the group consisting of H, lower alkyl, halogen, alkoxyl, aryloxyl, aralkoxy and hydroxyl; R3 and R6 are each independently selected from the group consisting of H, hydroxy, lower alkyl, cycloalkyl, aryl, aralkyl, alkoxyl, hydroxycycloalkyl, alkoxycycloalkyl, hydroxyalkyl, aminoalkyl, acyloxy, acetoxy, and alkylaminoalkyl; and R2, R4, R5 and R7 are each independently selected from the group consisting of H, lower alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl, or R2 and R4 together or R5 and R7 together represent a C2 to C10 alkyl, hydroxyalkyl, or alkylene, or R3 and R4 together or R6 and R7 together are: wherein n is a number from 1 to 3, and R9 is H or —CONHR10NR11R12, wherein R10 is lower alkyl and R11 and R12 are each independently selected from the group consisting of H and lower alkyl.