-
公开(公告)号：US06955640B2
公开(公告)日：2005-10-18
申请号：US09967469
申请日：2001-09-28
CPC分类号： A61N5/1002 , A61N2005/1003
摘要： An apparatus and method for brachytherapy. One method includes locating a region of cardiac tissue having a relatively large probability of originating or transmitting electrical signals which result in arrhythmic activity and irradiating the region of cardiac tissue to reduce the amount of arrhythmic activity. Irradiating can include regulating protein expression of myocardial cells, killing myocardial cells, ablating myocardial cells, irradiating sleeves of atrial muscle that extend from a left atrial wall around the pulmonary veins, and/or creating lesions that block electrical conduction through myocardial tissue. Locating the region can include locating a foci of an atrial arrhythmia or locating the foci adjacent a pulmonary vein.
摘要翻译： 近距离放射治疗的装置和方法。 一种方法包括定位具有导致心律失常活动并且照射心脏组织区域以减少心律不齐活动量的起始或发射电信号的较大概率的心脏组织区域。 辐射可以包括调节心肌细胞的蛋白质表达，杀死心肌细胞，消融心肌细胞，照射从肺静脉周围的左心房壁延伸的心房肌套，和/或产生阻断心肌组织导电的损伤。 定位该区域可以包括定位心房心律失常的焦点或者定位邻近肺静脉的灶。
-
公开(公告)号：US07493162B2
公开(公告)日：2009-02-17
申请号：US10160269
申请日：2002-05-31
IPC分类号： A61N1/00
CPC分类号： A61F2/958 , A61B18/1492 , A61B2018/00375 , A61N5/1002
摘要： An apparatus and method for treating atrial fibrillation is described that uses a vascular stent deployed within the pulmonary veins of the left atrium. The stent may be used alone or in combination with chemical, thermal, electrical, or radioactive energy sources to ablate myocardial tissue residing in the pulmonary veins. The targeted myocardial tissue in the pulmonary veins will have been identified as the source of initiation and/or sustenance of atrial fibrillation. Ablation therapy using the pulmonary venous stent stops discharges from ectopic foci in the vein or alternatively stops impulses from reaching the left atrium. The deployed stent can then be left in place to prevent stenosis of the vein.
摘要翻译： 描述了一种用于治疗房颤的装置和方法，其使用部署在左心房的肺静脉内的血管支架。 支架可以单独使用或与化学，热，电或放射能源组合使用，以消融存在于肺静脉中的心肌组织。 肺静脉中的靶向心肌组织将被确定为心房颤动的起始和/或维持的来源。 使用肺静脉支架的消融治疗可以阻止静脉中异位灶的排出，或者停止脉冲到达左心房。 然后将部署的支架置于适当位置以防止静脉狭窄。
-
公开(公告)号：US06635056B2
公开(公告)日：2003-10-21
申请号：US09974465
申请日：2001-10-09
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2018/00702 , A61B2018/00791 , A61B2018/1407 , A61B2018/1467
摘要： Power signals having controllable peak-to-peak amplitudes are provided to electrode sets so that during a first period of time, a first amplitude signal is provided to a first electrode set and a second amplitude signal is provided to a second electrode set. The first amplitude is greater than the second amplitude and bipolar current flows from the first electrode set to the second electrode set. During a second period of time, a third amplitude signal is provided to the first electrode set and a fourth amplitude signal is provided to the second electrode set. The third amplitude is less than the fourth amplitude and the current flows from the second electrode set to the first electrode set. Alternating first and second periods of time establish repetitive bipolar current flow between electrode sets. The addition of a backplate establishes unipolar current flow.
摘要翻译： 具有可控的峰 - 峰幅度的功率信号被提供给电极组，使得在第一时间段期间，第一振幅信号被提供给第一电极组，并且第二振幅信号被提供给第二电极组。 第一幅度大于第二幅度，双极电流从第一电极组流到第二电极组。 在第二时间段期间，向第一电极组提供第三幅度信号，并将第四振幅信号提供给第二电极组。 第三振幅小于第四振幅，电流从第二电极组流向第一电极组。 交替的第一和第二时间段在电极组之间建立重复的双极电流。 背板的添加建立了单极电流。
-
4.发明申请METHOD AND APPARATUS FOR USING ATRIAL DISCRIMINATION ALGORITHMS TO DETERMINE OPTIMAL PACING THERAPY AND THERAPY TIMING 审中-公开方法和装置用于确定最佳治疗方案和治疗时间的ATRIAL DISRIMINATION ALGORITHMS公开(公告)号：US20100305639A1
公开(公告)日：2010-12-02
申请号：US12836784
申请日：2010-07-15
申请人： Victor T. Chen , David S. Wood , Milton M. Morris
发明人： Victor T. Chen , David S. Wood , Milton M. Morris
CPC分类号： A61N1/3622
摘要： A system and method which employs atrial discrimination algorithms to distinguish between different atrial arrhythmias occurring in a patient for selecting an optimal pacing therapy corresponding to the type of arrhythmia identified. In response to the detection of an atrial rate above the atrial tracking rate, discrimination criteria are applied to a detected atrial activity signal to distinguish between different types of supraventricular tachycardia, such as fast atrial flutter and other atrial flutter at a relatively slower rate, which may be occurring in the patient. The pacer is controlled to provide pacing therapy to a heart in a manner corresponding to the type of supraventricular tachycardia identified. The output of an atrial discrimination algorithm may be tracked and the trend thereof used to improve therapy timing. Various embodiments are disclosed herein.
摘要翻译： 一种使用心房辨别算法来区分患者发生的不同心房心律不齐的系统和方法，用于选择对应于确定的心律失常类型的最佳起搏治疗。 响应于心房率高于心房跟踪率的检测，将鉴别标准应用于检测到的心房活动信号，以区别不同类型的室上性心动过速，例如以较慢速率的快速心房扑动和其他心房扑动，其中 可能发生在患者身上。 控制起搏器以对应于所鉴定的室上性心动过速类型的方式向心脏提供起搏治疗。 可以跟踪心房辨别算法的输出，并且其趋势用于改善治疗时机。 本文公开了各种实施例。
-
5.发明授权Ablation system and method having multiple-sensor electrodes to assist in assessment of electrode and sensor position and adjustment of energy levels 有权消融系统和方法具有多个传感器电极，以帮助评估电极和传感器位置以及调节能级公开(公告)号：US06752804B2
公开(公告)日：2004-06-22
申请号：US09752782
申请日：2000-12-28
IPC分类号： A61B1804
CPC分类号： A61B18/1492 , A61B2017/00101 , A61B2018/0016 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797
摘要： A catheter carries a plurality of electrodes, each with multiple thermal sensors attached and is used to position the electrodes proximal biological tissue. A processor responsive to each of the thermal sensors determines the temperature at the thermal-sensor/electrode junction. A display provides a graphic representation of the temperatures of the thermal-sensor/electrode junctions. An exemplary representation is a bar graph having the temperature of one thermal sensor at one end and the temperature of another thermal sensor at the other end. The length of the bar graph combined with the position of the bar graph relative to a temperature range region provides an indication of the position of the thermal-sensor/electrode junctions relative to the biological tissue. The processor also monitors the spread between the sensor temperatures and compares it to a threshold value. Base on the result of the comparison, the processor controls the power applied to the electrode.
摘要翻译： 导管携带多个电极，每个具有多个热传感器，并且用于将电极定位在生物组织的近端。 响应于每个热传感器的处理器确定热传感器/电极结处的温度。 显示器提供热传感器/电极接头的温度的图示。 示例性表示是具有一端的一个热传感器的温度和另一端的另一个热传感器的温度的条形图。 条形图的长度与条形图相对于温度范围区域的位置相结合提供热传感器/电极接头相对于生物组织的位置的指示。 处理器还监控传感器温度之间的差异，并将其与阈值进行比较。 基于比较的结果，处理器控制施加到电极的电力。
-
6.发明授权Method and apparatus for using atrial discrimination algorithms to determine optimal pacing therapy and therapy timing 有权使用心房辨别算法确定最佳起搏治疗和治疗时机的方法和装置公开(公告)号：US06978177B1
公开(公告)日：2005-12-20
申请号：US09712600
申请日：2000-11-14
申请人： Victor T. Chen , David S. Wood , Milton M. Morris
发明人： Victor T. Chen , David S. Wood , Milton M. Morris
CPC分类号： A61N1/3622
摘要： A system and method which employs atrial discrimination algorithms to distinguish between different atrial arrhythmias occurring in a patient for selecting an optimal pacing therapy corresponding to the type of arrhythmia identified. The invention may be implemented in a bradycardia pacemaker or other implantable cardiac device. In response to the detection of an atrial rate above the atrial tracking rate, discrimination criteria are applied to a detected atrial activity signal to distinguish between different types of supraventricular tachycardia, such as fast atrial flutter and other atrial flutter at a relatively slower rate, which may be occurring in the patient. The discrimination criteria may be, for example, rate-based or morphology based. The pacer is controlled to provide pacing therapy to a heart in a manner corresponding to the type of supraventricular tachycardia identified. For example, antitachycardia pacing may be provided to the heart in response to the detection of a relatively lower rate supraventricular tachycardia/other atrial flutter, whereas another pacing control, e.g., ventricular pacing, such as ventricular rate regulation or Rate Smoothing, may be applied if a more rapid rate supraventricular tachycardia/fast atrial flutter is identified. The output of an atrial discrimination algorithm may be tracked and the trend thereof used to improve therapy timing.
摘要翻译： 一种使用心房辨别算法来区分患者发生的不同心房心律不齐的系统和方法，用于选择对应于确定的心律失常类型的最佳起搏治疗。 本发明可以在心动过缓起搏器或其他可植入的心脏装置中实现。 响应于心房率高于心房跟踪率的检测，将鉴别标准应用于检测到的心房活动信号，以区别不同类型的室上性心动过速，例如以较慢速率的快速心房扑动和其他心房扑动，其中 可能发生在患者身上。 歧视标准可以是例如基于速率或基于形态的。 控制起搏器以对应于所鉴定的室上性心动过速类型的方式向心脏提供起搏治疗。 例如，可以响应于检测相对较低的室上性心动过速/其他心房扑动而向心脏提供抗心动过速起搏，而可以应用另一起搏控制，例如心室起搏，例如心室速率调节或速率平滑 如果确定更快速的室上性心动过速/快速心房扑动。 可以跟踪心房辨别算法的输出，并且其趋势用于改善治疗时机。
-
7.发明授权公开(公告)号：US06582429B2
公开(公告)日：2003-06-24
申请号：US09902038
申请日：2001-07-10
申请人： Mohan Krishnan , Wade A. Bowe , David S. Wood , Jeffrey A. Hall
发明人： Mohan Krishnan , Wade A. Bowe , David S. Wood , Jeffrey A. Hall
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2018/00065 , A61B2018/00083 , A61B2018/00113 , A61B2018/00136 , A61B2018/1467
摘要： A surface covering including a primary layer of a porous polymer structure and a secondary surface covering one or both of a metallic element layer and a hydrophilic layer is positioned over the surface of an ablation electrode. The pores of the surface covering are sized such that blood platelets are prevented from contacting the surface of the electrode while physiological fluid is allowed to pass through and contact the electrode surface to hereby provide a conduction path for current from the electrodes. The surface covering may further include an electrically non-conductive and thermally conductive portion positioned over another portion of the electrode to prevent alternate or non-intended site ablations.
摘要翻译： 包括多孔聚合物结构的主层和覆盖金属元素层和亲水层中的一个或两个的次表面的表面覆盖物位于消融电极的表面上。 表面覆盖物的孔的尺寸使得防止血小板接触电极的表面，同时允许生理流体通过并接触电极表面，从而提供来自电极的电流的传导路径。 表面覆盖物还可以包括位于电极的另一部分上的非导电和导热部分，以防止交替或非预期的部位消融。
-
公开(公告)号：US07209783B2
公开(公告)日：2007-04-24
申请号：US10123897
申请日：2002-04-16
申请人： Chris Fellows , Wade A. Bowe , David S. Wood
发明人： Chris Fellows , Wade A. Bowe , David S. Wood
CPC分类号： A61F2/82 , A61B18/1492 , A61B2018/00214 , A61B2018/00375
摘要： An apparatus and method for treating atrial fibrillation with ablation therapy in which a stent is deployed within a pulmonary vein and tissue surrounding the stent is ablated with radiofrequency energy to stop discharges from ectopic foci in the vein from reaching the left atrium. The deployed stent can then be left in place to prevent stenosis of the vein as well as allowing repeat ablation procedures as needed.
摘要翻译： 一种用消融治疗来治疗房颤的装置和方法，其中支架被部署在肺静脉内并且支架周围的组织被射频能量消融以阻止静脉中异位灶的排出物到达左心房。 然后将部署的支架置于适当位置以防止静脉狭窄以及根据需要允许重复消融手术。
-
公开(公告)号：US06755824B2
公开(公告)日：2004-06-29
申请号：US10123830
申请日：2002-04-15
申请人： Mudit K. Jain , Milton M. Morris , Jeffrey A. Hall , Gregory P. Walcott , Bruce KenKnight , David S. Wood
发明人： Mudit K. Jain , Milton M. Morris , Jeffrey A. Hall , Gregory P. Walcott , Bruce KenKnight , David S. Wood
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2218/002
摘要： An ablation catheter stores a platelet inhibitor substance within a plurality of pockets or recesses of its shaft. The substance is adapted to elute upon contact with biological fluid. In the pocket configuration, the platelet inhibitor substance is in a capsule positioned within the pocket. In the recess configuration, the platelet inhibitor substance is in a hydrogel or silicone-based porous/semi-porous matrix positioned within the recess. Elution of the platelet inhibitor substance prevents or at least substantially minimizes the adhesion of blood platelets on the catheter surface during ablation. In another configuration, the catheter includes an internal lumen network having apertures terminating at the surface of the shaft. The lumen communicates with a source of platelet inhibitor fluid that is forced through the lumen by a variable pump.
摘要翻译： 消融导管将血小板抑制剂物质存储在其轴的多个口袋或凹槽内。 该物质适于在与生物液体接触时洗脱。 在口袋结构中，血小板抑制物质位于口袋内的胶囊中。 在凹陷结构中，血小板抑制剂物质是位于凹陷内的水凝胶或硅酮基多孔/半多孔基体。 血小板抑制剂物质的洗脱防止或至少基本上最小化在消融期间血小板在导管表面上的粘附。 在另一种构造中，导管包括内孔管网，其具有终止于轴表面处的孔。 管腔与血小板抑制剂流体源连通，该血小板抑制剂流体通过可变泵被迫通过内腔。
-
10.发明授权公开(公告)号：US06730078B2
公开(公告)日：2004-05-04
申请号：US10127622
申请日：2002-04-22
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00726 , A61B2018/128 , A61B2018/1435
摘要： A first power output with a first frequency is provided to a first set of electrodes while a second power output with a second frequency, different then the first frequency, is provided to a second set of electrodes. Power outputs are provided to electrodes so adjacent electrodes receive power outputs with different frequencies, thereby establishing a voltage potential between adjacent electrodes and bipolar current flow. The frequencies of the power outputs are selected such that the resultant waveform indicative of the magnitude of the amplitude difference between the outputs has a period short enough to avoid stimulation of excitable muscular and cardiac tissue. Periodic frequency switching between the first and second power output provides uniform current flow between the electrodes over a given period of time. The addition of a backplate establishes unipolar current flow.
摘要翻译： 具有第一频率的第一功率输出被提供给第一组电极，而具有与第一频率不同的第二频率的第二功率输出提供给第二组电极。 功率输出提供给电极，所以相邻的电极接收具有不同频率的功率输出，由此建立相邻电极之间的电压电位和双极电流。 选择功率输出的频率，使得指示输出之间的幅度差大小的合成波形具有足够短的时间段，以避免可激发的肌肉和心脏组织的刺激。 在第一和第二功率输出之间的周期性频率切换在给定的时间段内提供在电极之间均匀的电流流动。 背板的添加建立了单极电流。
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.023 秒)
