公开(公告)号：US6117859A

公开(公告)日：2000-09-12

申请号：US407244

申请日：1999-09-28

申请人： Richard T. Evans ,  Robert A. Coburn ,  Robert J. Genco ,  Joseph A. Dunn

发明人： Richard T. Evans ,  Robert A. Coburn ,  Robert J. Genco ,  Joseph A. Dunn

IPC分类号： A61K9/107 ,  A61K31/167 ,  A61K31/63

CPC分类号： A61K31/609 ,  A61K31/167 ,  A61K9/1075

摘要： A method of treating chronic inflammation in a mammal is disclosed which comprises contacting the affected area with an amount sufficient to ameliorate the inflammatory condition, of a compound of the following formula: ##STR1## wherein Z is a substituted phenyl ring, R is an alkylsulfonyl group of 1-20 carbon atoms, and X is selected from the group consisting of --CN, --NO.sub.2, --H, halogen, lower alkyl and lower haloalkyl.

摘要翻译： 公开了一种治疗哺乳动物慢性炎症的方法，其包括使受影响的区域与足以改善炎性病症的量接触下式的化合物：其中Z是取代的苯环，R是1的烷基磺酰基 -20个碳原子，X选自-CN，-NO 2，-H，卤素，低级烷基和低级卤代烷基。

公开(公告)号：US5958911A

公开(公告)日：1999-09-28

申请号：US963751

申请日：1997-11-04

申请人： Richard T. Evans ,  Robert A. Coburn ,  Robert A. Genco ,  Joseph A. Dunn

发明人： Richard T. Evans ,  Robert A. Coburn ,  Robert A. Genco ,  Joseph A. Dunn

IPC分类号： A61K9/107 ,  A61K31/167 ,  A61K31/615

CPC分类号： A61K31/609 ,  A61K31/167 ,  A61K9/1075

摘要： A method of treating inflammation in a mammal, which comprises contacting the affected area with an amount sufficient to ameliorate the inflammatory condition, of a compound of the following formula ##STR1## in a pharmaceutically acceptable carrier containing a detergent, where Z is a substituted phenyl, R is a substituted or unsubstituted alkylsulfonyl group from 1 to 20 carbon atoms and X is --CN, --NO.sub.2, --H, halogen, lower alkyl or lower haloalkyl radical.

摘要翻译： 一种治疗哺乳动物的炎症的方法，其包括使受影响的区域与足以改善炎性病症的量接触下式化合物在含有洗涤剂的药学上可接受的载体中，其中Z是取代的苯基，R是 取代或未取代的碳原子数1〜20的烷基磺酰基，X为-CN，-NO 2，-H，卤素，低级烷基或低级卤代烷基。

公开(公告)号：US06532784B1

公开(公告)日：2003-03-18

申请号：US09786404

申请日：2001-04-02

申请人： Joseph A. Dunn ,  William P. Warkentin ,  Edward Elizondo

发明人： Joseph A. Dunn ,  William P. Warkentin ,  Edward Elizondo

IPC分类号： B21D915

CPC分类号： B21D26/053 ,  B21D37/18 ,  C10M101/02 ,  C10M101/025 ,  C10M105/525 ,  C10M109/02 ,  C10M2205/163 ,  C10M2207/2815 ,  C10M2211/083 ,  C10M2213/00 ,  C10M2219/044 ,  C10M2223/00 ,  C10M2227/00 ,  C10N2240/402 ,  C10N2240/405 ,  C10N2250/04 ,  C10N2260/04 ,  C10N2260/06

摘要： A process of mechanical hydroforming, in which a hollow tube is caused to expand against the interior surface of a die that surrounds the tube by hydraulic pressure applied to a liquid that fills the interior of the tube, is improved by coating the part of the exterior surface of the tube that comes into contact with the die surface against which it expands with a wax that is solid at normal room temperature but can be maintained fully melted and in contact with air, without showing any visible evidence of decomposition, at a temperature that is at least 75 degrees C. Preferably, the wax is applied to the surface to be hydroformed by spraying from melt onto the surface while the latter is maintained above the melt temperature of the wax. Shortly after the wax has been thus applied to the surface, the wax is cooled until it solidifies. Most preferably, the wax is an “oxidized hydrocarbon” wax that is about 95% hydrocarbon and 5% straight chain carboxylic acids and contains a wide variety of molecular weights of both hydrocarbons and carboxylic acids.

摘要翻译： 一种机械液压成型方法，其中使中空管通过施加到填充管内部的液体的液压而围绕管的模具的内表面膨胀，通过涂覆外部的一部分而得到改善 与模具表面接触的管的表面，其与其在正常室温下为固体的蜡膨胀，但是可以保持完全熔化并与空气接触，而不显示任何明显的分解迹象，温度在 至少为75摄氏度。优选地，蜡通过从熔体喷射到表面上而被施加到待加氢成形的表面上，同时将蜡保持在蜡的熔融温度以上。 在将蜡施加到表面之后不久，将蜡冷却直到其固化。 最优选地，蜡是约95％烃和5％直链羧酸的“氧化烃”蜡，并且含有各种各样的烃和羧酸的分子量。