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公开(公告)号：US06407288B1
公开(公告)日：2002-06-18
申请号：US09969071
申请日：2001-10-02
IPC分类号： C07C23365
CPC分类号： C07C255/60 , C07C235/84
摘要： The present invention discloses novel naphthylsalicylanilides of the general formula wherein W is a substituted or unsubstituted naphthyl ring. The substitution on W includes replacing one or more —H with —OH, alkyl, O-alkyl, branched alkyl, or cycloalkyl, containing 1-6 carbon atoms or combinations thereof. Y is a substituted or unsubstituted phenyl ring or substituted or unsubstituted naphthyl ring. The substitution for Y includes replacement of one or more —H atoms with CN, CF3, NO2, methoxy, benzoyl, phenoxy, phenoxymethyl or combinations thereof. These compounds are useful as antibacterial against gram negative and gram positive bacteria and as antiinflammatory agents.
摘要翻译： 本发明公开了通式为W的取代或未取代的萘基萘基新的萘磺酰苯胺。 在W上的取代包括用含1-6个碳原子的-OH，烷基，O-烷基，支链烷基或环烷基取代一个或多个-H或其组合。 Y是取代或未取代的苯基环或取代或未取代的萘基环。 取代Y包括用CN，CF 3，NO 2，甲氧基，苯甲酰基，苯氧基，苯氧基甲基或其组合取代一个或多个-H原子。 这些化合物可用作抗革兰氏阴性和革兰氏阳性菌和抗炎剂的抗菌剂。
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2.发明授权Novel 5-alkylsulfonylsalicylanilides and microbiocidal compositions for controlling the growth of microorganisms 失效用于控制微生物生长的新型5-烷基磺酰基水杨酰胺和杀微生物组合物
公开(公告)号：US4939132A
公开(公告)日：1990-07-03
申请号：US723080
申请日：1985-04-15
IPC分类号： A61K31/60 , A61K8/46 , A61K8/69 , A61K31/165 , A61K31/18 , A61P1/02 , A61P31/04 , A61Q11/00 , C07C67/00 , C07C233/12 , C07C233/65 , C07C313/00 , C07C317/46 , C07C323/65
摘要： This invention relates to new 5-alkylsulfonylsalicylanilides and methods for their use. More particularly, the invention relates to compounds of the formula: ##STR1## Wherein Z is a substituted or unsubstituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a substituted or unsubstituted alkylsulfonyl group of from 1 to 20 carbon atoms including substitutents; and X is a radical selected from the group consisting of --CN, --NO.sub.2, --H, halogen, lower alkyl or lower haloalkyl.The above compounds and compositions containing them are effective antiseptics against a wide range of microorganisms, especially bacteria, and are surprisingly highly effective against microorganisms, particularly S. mutans, prevalent in dental plaque.
摘要翻译： 本发明涉及新的5-烷基磺酰基水杨酰胺及其使用方法。 更具体地说，本发明涉及下式的化合物：其中Z是取代或未取代的6至30个碳原子的苯环，包括取代基，R是1至20个碳原子的取代或未取代的烷基磺酰基，包括 替代品 X为选自-CN，-NO 2，-H，卤素，低级烷基或低级卤代烷基的基团。 上述含有它们的化合物和组合物是广泛的微生物，特别是细菌的有效的防腐剂，并且对于在牙菌斑中普遍存在的微生物，特别是变形链球菌，令人惊奇地高度有效。
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公开(公告)号：US4358443A
公开(公告)日：1982-11-09
申请号：US176419
申请日：1980-08-08
IPC分类号： A01N37/40 , A61K8/42 , A61K8/69 , A61Q11/00 , C07C65/40 , C07C233/12 , A01N37/36 , C07C103/29
摘要： The composition comprises certain 5-alkylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: ##STR1## Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, and R is a substituted or unsubstituted n-alkyl or phenyl group of from 4 to 30 carbon atoms including substituents.The preferred compositions of the invention have a partition coefficient greater than 4 and the substituted moieties in the phenyl ring of the Z group have a combined overall electron withdrawing effect on the phenyl ring of the Z group.The method of the invention comprises contacting a microorganism affected by the above composition with a sufficient concentration of the above composition for a sufficient time to inhibit the growth of the microorganism.The above compositions are effective antiseptics against a wide range of microorganisms, especially bacteria, and the compositions surprisingly are effective against microorganisms prevalent in dental plaque.
摘要翻译： 该组合物包含某些5-烷基水杨酰胺，更具体地包括由以下通式所包括的化合物：其中Z是含有6至30个碳原子的取代苯环，包括取代基，R是取代或未取代的正烷基 或含有4-30个碳原子的苯基，包括取代基。 本发明的优选组合物具有大于4的分配系数，并且Z基团的苯环中的取代部分在Z基团的苯环上具有组合的总吸电子效应。 本发明的方法包括使受上述组合物影响的微生物与足够浓度的上述组合物接触足够的时间以抑制微生物的生长。 上述组合物是针对广泛的微生物，特别是细菌的有效的防腐剂，并且该组合物令人惊奇地对于牙菌斑中普遍存在的微生物是有效的。
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公开(公告)号：US20100063474A1
公开(公告)日：2010-03-11
申请号：US12555554
申请日：2009-09-08
IPC分类号： A61M5/31
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/2033 , A61M5/2053 , A61M5/31511 , A61M2005/31598
摘要： The present invention relates to a mixing syringe device for delivering a medicament or medical composition to a site of interest. The mixing syringe device generally includes a multi-chambered open lumen and optionally a sectioned plunger. The open lumen has at least two longitudinally oriented chambers within the interior of the lumen, and the optional sectioned plunger has at least two longitudinally oriented extensions corresponding in configuration to the at least two longitudinally oriented chambers of the open lumen and configured to be reciprocatably disposed in the chambers of the open lumen. Each compartment of the lumen is configured to store a medicament component or medical composition component in its interior. In certain embodiments, each compartment is sealed at one end by a movable stopper mechanism and sealed at the other end by a sealing mechanism capable of temporarily or otherwise opening. Methods of use are also provided.
摘要翻译： 本发明涉及用于将药物或医疗组合物输送到感兴趣的部位的混合注射器装置。 混合注射器装置通常包括多室开口腔和可选地分段柱塞。 开放的内腔在内腔的内部具有至少两个纵向定向的腔室，并且任选的分段柱塞具有至少两个纵向定向的延伸部，其构造与开放腔的至少两个纵向定向腔相对应，并被构造成可往复运动地设置 在开放的腔的腔室。 管腔的每个隔室被构造成在其内部存储药物成分或医用组合物成分。 在某些实施例中，每个隔室在一端通过可移动止动机构密封，并在另一端通过能够暂时或以其他方式打开的密封机构密封。 还提供了使用方法。
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5.发明授权
公开(公告)号：US4287191A
公开(公告)日：1981-09-01
申请号：US140098
申请日：1980-04-14
IPC分类号： A61K31/60 , A01N37/36 , A61K8/42 , A61K8/69 , A61K31/165 , A61P1/02 , A61P31/04 , A61Q11/00 , C07C65/40 , C07C233/12 , C07C101/74 , C07C119/02
摘要： The composition comprises certain 5-acylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: ##STR1## Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a substituted or unsubstituted alkyl or phenyl group of from 2 to 30 carbon atoms including substituents and M is a radical selected from the group consisting of --C.dbd.N,--F,--NO.sub.2,--H, lower alkyl or lower haloalkyl.The preferred compositions of the invention have a partition coefficient greater than 4 and the substituted moieties in the phenyl ring of the Z group have a combined overall electron withdrawing effect on the phenyl ring of the Z group.The method of the invention comprises contacting the microorganism with a sufficient concentration of the above composition for a sufficient time to inhibit the growth of the microorganism.The above compositions are effective antiseptics against a wide range of microorganisms, especially bacteria, and the compositions surprisingly are especially effective against microorganisms prevalent in dental plaque.
摘要翻译： 该组合物包含某些5-酰基水杨酰苯胺，更具体地包括由以下通式所包括的化合物：其中Z是包含取代基的6至30个碳原子的取代苯环，R是取代或未取代的烷基或苯基 包括2至30个碳原子，包括取代基，M是选自-C = N，-F，-NO 2，-H，低级烷基或低级卤代烷基的基团。 本发明的优选组合物具有大于4的分配系数，并且Z基团的苯环中的取代部分在Z基团的苯环上具有组合的总吸电子效应。 本发明的方法包括使足够浓度的上述组合物的微生物接触足够的时间以抑制微生物的生长。 上述组合物是针对广泛的微生物，特别是细菌的有效的防腐剂，并且该组合物令人惊奇地对抗牙菌斑中普遍存在的微生物特别有效。
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公开(公告)号：US07178659B2
公开(公告)日：2007-02-20
申请号：US11031731
申请日：2005-01-07
IPC分类号： B65G47/54
CPC分类号： B65G47/54 , B65G2201/025 , B65G2201/0264
摘要： An novel apparatus and technique may be used to induct articles onto a conveyor comprising at least one conveyor belt that moves articles along a first path that extends in a first direction. The apparatus may be used to move an article along a second path that extends in a second direction, which is transverse to the first direction, to a first position above but not in contact with the at least one conveyor belt. After the article has been moved to the first position above but not in contact with the at least one conveyor belt, the apparatus may be used to move the article onto the at least one conveyor belt.
摘要翻译： 可以使用新颖的装置和技术将物品引导到输送机上，该输送机包括沿着沿第一方向延伸的第一路径移动物品的至少一个输送带。 该装置可以用于沿着沿与第一方向横切的第二方向延伸到第二位置的第二路径移动物品到上述第一位置，但不与该至少一个传送带接触。 在物品已经移动到上面的第一位置而不与至少一个传送带接触之后，该设备可以用于将物品移动到至少一个传送带上。
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公开(公告)号：US06907978B2
公开(公告)日：2005-06-21
申请号：US10701823
申请日：2003-11-05
CPC分类号： B65G47/54 , B65G2201/025 , B65G2201/0264
摘要： An novel apparatus and technique may be used to induct articles onto a conveyor comprising at least one conveyor belt that moves articles along a first path that extends in a first direction. The apparatus may be used to move an article along a second path that extends in a second direction, which is transverse to the first direction, to a first position above but not in contact with the at least one conveyor belt. After the article has been moved to the first position above but not in contact with the at least one conveyor belt, the apparatus may be used to move the article onto the at least one conveyor belt.
摘要翻译： 可以使用新颖的装置和技术将物品引导到输送机上，该输送机包括沿着沿第一方向延伸的第一路径移动物品的至少一个输送带。 该装置可以用于沿着沿与第一方向横切的第二方向延伸到第二位置的第二路径移动物品到上述第一位置，但不与该至少一个传送带接触。 在物品已经移动到上面的第一位置而不与至少一个传送带接触之后，该设备可以用于将物品移动到至少一个传送带上。
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8.发明授权
公开(公告)号：US5958911A
公开(公告)日：1999-09-28
申请号：US963751
申请日：1997-11-04
IPC分类号： A61K9/107 , A61K31/167 , A61K31/615
CPC分类号： A61K31/609 , A61K31/167 , A61K9/1075
摘要： A method of treating inflammation in a mammal, which comprises contacting the affected area with an amount sufficient to ameliorate the inflammatory condition, of a compound of the following formula ##STR1## in a pharmaceutically acceptable carrier containing a detergent, where Z is a substituted phenyl, R is a substituted or unsubstituted alkylsulfonyl group from 1 to 20 carbon atoms and X is --CN, --NO.sub.2, --H, halogen, lower alkyl or lower haloalkyl radical.
摘要翻译： 一种治疗哺乳动物的炎症的方法，其包括使受影响的区域与足以改善炎性病症的量接触下式化合物在含有洗涤剂的药学上可接受的载体中，其中Z是取代的苯基，R是 取代或未取代的碳原子数1〜20的烷基磺酰基，X为-CN，-NO 2，-H，卤素，低级烷基或低级卤代烷基。
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公开(公告)号：US5432055A
公开(公告)日：1995-07-11
申请号：US72067
申请日：1993-06-02
CPC分类号： C12Q1/689
摘要： The present invention relates to novel compositions comprising P. gingivalis specific oligonucleotides which are useful as primers to amplify particular regions of the genome of P. gingivalis during enzymatic nucleic acid amplification. The invention also provides a method for the detection of P. gingivalis, which may be present in a clinical specimen, using the P. gingivalis-specific primers and enzymatic nucleic acid amplification. The present invention also relates to P. gingivalis-specific oligonucleotides which are useful as probes to facilitate detection of the amplified regions of P. gingivalis DNA.
摘要翻译： 本发明涉及包含牙龈卟啉单胞菌特异性寡核苷酸的新型组合物，其可用作扩增酶核酸扩增期间牙龈卟啉单胞菌基因组的特定区域的引物。 本发明还提供了使用牙龈卟啉单胞菌特异性引物和酶促核酸扩增来检测牙龈卟啉单胞菌的方法，其可存在于临床标本中。 本发明还涉及牙龈卟啉单胞菌特异性寡核苷酸，其可用作促进牙龈卟啉单胞菌DNA扩增区域检测的探针。
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公开(公告)号：US08353866B2
公开(公告)日：2013-01-15
申请号：US12555554
申请日：2009-09-08
IPC分类号： A61M37/00
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/2033 , A61M5/2053 , A61M5/31511 , A61M2005/31598
摘要： The present invention relates to a mixing syringe device for delivering a medicament or medical composition to a site of interest. The mixing syringe device generally includes a multi-chambered open lumen and optionally a sectioned plunger. The open lumen has at least two longitudinally oriented chambers within the interior of the lumen, and the optional sectioned plunger has at least two longitudinally oriented extensions corresponding in configuration to the at least two longitudinally oriented chambers of the open lumen and configured to be reciprocatably disposed in the chambers of the open lumen. Each compartment of the lumen is configured to store a medicament component or medical composition component in its interior. In certain embodiments, each compartment is sealed at one end by a movable stopper mechanism and sealed at the other end by a sealing mechanism capable of temporarily or otherwise opening. Methods of use are also provided.
摘要翻译： 本发明涉及用于将药物或医疗组合物输送到感兴趣的部位的混合注射器装置。 混合注射器装置通常包括多室开口腔和可选地分段柱塞。 开放的内腔在内腔的内部具有至少两个纵向定向的腔室，并且任选的分段柱塞具有至少两个纵向定向的延伸部，其构造与开放腔的至少两个纵向定向腔相对应，并被构造成可往复运动地布置 在开放的腔的腔室。 管腔的每个隔室被构造成在其内部存储药物成分或医用组合物成分。 在某些实施例中，每个隔室在一端通过可移动止动机构密封，并在另一端通过能够暂时或以其他方式打开的密封机构密封。 还提供了使用方法。
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