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公开(公告)号：US20050197378A1
公开(公告)日：2005-09-08
申请号：US11005524
申请日：2004-12-06
IPC分类号： A61K20060101 , A61K31/343 , A61K31/4178 , C07D307/87
CPC分类号： C07D307/80
摘要： A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense, a Trypanosoma cruzi, and Plasmodium falciparum, and fungal pathogens, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.
摘要翻译： 一种通过向受试者施用有效量的阳离子取代的苯并呋喃化合物来治疗有需要的受试者的结核分枝杆菌感染的方法。 治疗微生物感染的方法，包括原生动物病原体的感染，例如杜氏利什曼原虫，罗非鱼锥虫，克氏锥虫和恶性疟原虫，以及真菌病原体，例如白色念珠菌，烟曲霉和新型隐球酵母，需要的受试者 其通过向受试者施用有效量的阳离子取代的苯并呋喃化合物。 合成新型阳离子取代苯并呋喃化合物和新化合物本身的方法。
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公开(公告)号：US20080114047A1
公开(公告)日：2008-05-15
申请号：US11982271
申请日：2007-10-31
IPC分类号： A61K31/4178 , A61K31/343 , C07D405/02 , C07D307/02
CPC分类号： C07D307/80
摘要： A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense, a Trypanosoma cruzi, and Plasmodium falciparum, and fungal pathogens, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.
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公开(公告)号：US07417158B2
公开(公告)日：2008-08-26
申请号：US11005524
申请日：2004-12-06
申请人： Richard R. Tidwell , Karl Werbovetz , Scott Gary Franzblau , Svetlana Bakunova , Stanislav Bakunov
发明人： Richard R. Tidwell , Karl Werbovetz , Scott Gary Franzblau , Svetlana Bakunova , Stanislav Bakunov
IPC分类号： C07D307/00 , A61K31/415 , A61K31/34
CPC分类号： C07D307/80
摘要： A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense, a Trypanosoma cruzi, and Plasmodium falciparum, and fungal pathogens, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.
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公开(公告)号：US20080221191A1
公开(公告)日：2008-09-11
申请号：US11982229
申请日：2007-10-31
申请人： Richard R. Tidwell , Karl Werbovetz , Scott Gary Franzblau , Svetlana Bakunova , Stanislav Bakunov
发明人： Richard R. Tidwell , Karl Werbovetz , Scott Gary Franzblau , Svetlana Bakunova , Stanislav Bakunov
IPC分类号： A61K31/4178 , C07D307/78 , A61K31/343 , C07D407/02 , A61P31/04
CPC分类号： C07D307/80
摘要： A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense, a Trypanosoma cruzi, and Plasmodium falciparum, and fungal pathogens, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.
摘要翻译： 一种通过向受试者施用有效量的阳离子取代的苯并呋喃化合物来治疗有需要的受试者的结核分枝杆菌感染的方法。 治疗微生物感染的方法，包括原生动物病原体的感染，例如杜氏利什曼原虫，罗非鱼锥虫，克氏锥虫和恶性疟原虫，以及真菌病原体，例如白色念珠菌，烟曲霉和新型隐球酵母，需要的受试者 其通过向受试者施用有效量的阳离子取代的苯并呋喃化合物。 合成新型阳离子取代苯并呋喃化合物和新化合物本身的方法。
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5.发明申请公开(公告)号：US20060264487A1
公开(公告)日：2006-11-23
申请号：US11415982
申请日：2006-05-02
IPC分类号： A61K31/42 , C07D261/06 , C07D413/02
CPC分类号： C07D261/08 , C07D413/10 , C07D413/14
摘要： Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.
摘要翻译： 描述了新型的阳离子3,5-二苯基异恶唑化合物。 提供了这些新化合物的合成路线。 几种化合物显示体外活性与布鲁斯氏锥虫和恶性疟原虫相当，与呋喃丹相当。 大多数新型化合物对VERO细胞的毒性相对于呋脒更少。
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6.发明授权公开(公告)号：US07951827B2
公开(公告)日：2011-05-31
申请号：US11415982
申请日：2006-05-02
IPC分类号： A61K31/42 , C07D261/06 , C07D413/02
CPC分类号： C07D261/08 , C07D413/10 , C07D413/14
摘要： Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.
摘要翻译： 描述了新型的阳离子3,5-二苯基异恶唑化合物。 提供了这些新化合物的合成路线。 几种化合物显示体外活性与布鲁斯氏锥虫和恶性疟原虫相当，与呋喃丹相当。 大多数新型化合物对VERO细胞的毒性相对于呋脒更少。
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