公开(公告)号：US20070112296A1

公开(公告)日：2007-05-17

申请号：US11643471

申请日：2006-12-21

申请人： Richard Wilson ,  Robert Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Barrere ,  Amy Cohen ,  George Keilman ,  Leonard Oliver ,  Natalya Peskin

发明人： Richard Wilson ,  Robert Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Barrere ,  Amy Cohen ,  George Keilman ,  Leonard Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

公开(公告)号：US20070106203A1

公开(公告)日：2007-05-10

申请号：US11643417

申请日：2006-12-21

申请人： Richard Wilson ,  Robert Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Barrere ,  Amy Cohen ,  George Keilman ,  Leonard Oliver ,  Natalya Peskin

发明人： Richard Wilson ,  Robert Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Barrere ,  Amy Cohen ,  George Keilman ,  Leonard Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

摘要翻译： 用于将超声能量和治疗性化合物递送到患者脉管系统内的治疗部位的导管包括管状体。 管状体具有近端区域和与近端区域相对的远端区域。 导管还包括形成在管状体中的多个流体输送腔。 该导管还包括构造成用于插入管状体的内芯。 内芯包括具有多个扁平区域的细长电导体，每个扁平区域具有第一平坦侧和与第一平坦侧相对的第二平坦侧。 内芯还包括与细长电导体的扁平区域成对安装的多个超声波辐射构件。 第一超声波辐射构件安装到细长电导体的第一平坦侧，并且第二超声波辐射构件安装到细长电导体的第二平坦侧。 导管还包括配置成将驱动信号施加到超声辐射构件的至少两个但是少于全部的控制电子设备。

公开(公告)号：US07727178B2

公开(公告)日：2010-06-01

申请号：US11643471

申请日：2006-12-21

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

公开(公告)号：US08696612B2

公开(公告)日：2014-04-15

申请号：US13431798

申请日：2012-03-27

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61M25/00

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The ultrasonic catheter system comprises a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end, a fluid delivery lumen, at least one ultrasound radiating element positioned in the treatment zone, wiring electrically coupled to the at least one ultrasound radiating element and extending through the tubular body and terminating at a connector, and a control system comprising external circuitry and an isolation pod that is configured to be electrically connected to the connector, the isolation pod being positioned between the tubular body and the external system and comprising an isolation barrier and circuitry for driving the ultrasound radiating element.

摘要翻译： 公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。 超声导管系统包括管状体，其具有位于远端和近端之间的近端，远端和处理区，流体输送腔，位于治疗区中的至少一个超声波辐射元件，电耦合 到所述至少一个超声波辐射元件并且延伸穿过所述管状主体并且终止于连接器，以及包括外部电路的控制系统和被配置为电连接到所述连接器的隔离盒，所述隔离盒位于所述管状 主体和外部系统，并且包括用于驱动超声波辐射元件的隔离屏障和电路。

公开(公告)号：US20120253237A1

公开(公告)日：2012-10-04

申请号：US13431798

申请日：2012-03-27

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61N7/00 ,  A61M25/00

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The ultrasonic catheter system comprises a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end, a fluid delivery lumen, at least one ultrasound radiating element positioned in the treatment zone, wiring electrically coupled to the at least one ultrasound radiating element and extending through the tubular body and terminating at a connector, and a control system comprising external circuitry and an isolation pod that is configured to be electrically connected to the connector, the isolation pod being positioned between the tubular body and the external system and comprising an isolation barrier and circuitry for driving the ultrasound radiating element.

摘要翻译： 公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。 超声导管系统包括管状体，其具有位于远端和近端之间的近端，远端和处理区，流体输送腔，位于治疗区中的至少一个超声波辐射元件，电耦合 到所述至少一个超声波辐射元件并且延伸穿过所述管状主体并且终止于连接器，以及包括外部电路的控制系统和被配置为电连接到所述连接器的隔离盒，所述隔离盒位于所述管状 主体和外部系统，并且包括用于驱动超声波辐射元件的隔离屏障和电路。

公开(公告)号：US08167831B2

公开(公告)日：2012-05-01

申请号：US12762254

申请日：2010-04-16

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The method comprises providing a catheter with a plurality of ultrasound radiating members, wherein the plurality of ultrasound radiating members are allocated into electrical groups comprising more than one ultrasound radiating member. The method further comprises independently driving each group of ultrasonic radiating members, and delivering the therapeutic compound through the catheter to the treatment site.

摘要翻译： 公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。 该方法包括提供具有多个超声辐射构件的导管，其中多个超声辐射构件被分配成包括多于一个超声波辐射构件的电组。 该方法还包括独立地驱动每组超声辐射构件，并将治疗化合物通过导管输送到治疗部位。

公开(公告)号：US07220239B2

公开(公告)日：2007-05-22

申请号：US10309388

申请日：2002-12-03

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

公开(公告)号：US07828762B2

公开(公告)日：2010-11-09

申请号：US11643417

申请日：2006-12-21

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

摘要翻译： 用于将超声能量和治疗性化合物递送到患者脉管系统内的治疗部位的导管包括管状体。 管状体具有近端区域和与近端区域相对的远端区域。 导管还包括形成在管状体中的多个流体输送腔。 该导管还包括构造成用于插入管状体的内芯。 内芯包括具有多个扁平区域的细长电导体，每个扁平区域具有第一平坦侧和与第一平坦侧相对的第二平坦侧。 内芯还包括与细长电导体的扁平区域成对安装的多个超声波辐射构件。 第一超声波辐射构件安装到细长电导体的第一平坦侧，并且第二超声波辐射构件安装到细长电导体的第二平坦侧。 导管还包括配置成将驱动信号施加到超声辐射构件的至少两个但是少于全部的控制电子设备。

公开(公告)号：US07384407B2

公开(公告)日：2008-06-10

申请号：US10309417

申请日：2002-12-03

申请人： Oscar Rodriguez ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Frederick J. Bennett ,  George Keilman ,  Richard R. Wilson ,  Perry Todd Thompson

发明人： Oscar Rodriguez ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Frederick J. Bennett ,  George Keilman ,  Richard R. Wilson ,  Perry Todd Thompson

IPC分类号： A61B17/20

CPC分类号： A61N7/00 ,  A61B17/2202 ,  A61M2025/0034 ,  A61M2025/0039 ,  A61N2007/0078

摘要： An ultrasound catheter adapted for accessing small vessels in the distal anatomy is disclosed. The ultrasound catheter comprises an elongate tubular body formed with a delivery lumen. The flexibility and dimensions of the tubular body allow access to the distal anatomy by advancement over the guidewire. An ultrasound radiating member is provided along the distal end portion of the tubular body for emitting ultrasound energy at a treatment site. A drug solution may also be delivered through the delivery lumen and out an exit port to the treatment site.

摘要翻译： 公开了适于接近远端解剖结构中的小血管的超声导管。 超声导管包括形成有输送腔的细长管状体。 管状体的灵活性和尺寸允许通过导丝进入远端解剖结构。 沿管状体的远端部设置有超声波辐射构件，用于在治疗部位发射超声能量。 药物溶液也可以通过输送腔输送出出口到治疗部位。

公开(公告)号：US20080221506A1

公开(公告)日：2008-09-11

申请号：US12126631

申请日：2008-05-23

申请人： Oscar E. Rodriguez ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Frederick J. Bennett ,  George Keilman ,  Richard R. Wilson ,  Perry Todd Thompson

发明人： Oscar E. Rodriguez ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Frederick J. Bennett ,  George Keilman ,  Richard R. Wilson ,  Perry Todd Thompson

IPC分类号： A61B17/22

CPC分类号： A61N7/00 ,  A61B17/2202 ,  A61M2025/0034 ,  A61M2025/0039 ,  A61N2007/0078

摘要： An ultrasound catheter adapted for accessing small vessels in the distal anatomy is disclosed. The ultrasound catheter comprises an elongate tubular body formed with a delivery lumen. The flexibility and dimensions of the tubular body allow access to the distal anatomy by advancement over the guidewire. An ultrasound radiating member is provided along the distal end portion of the tubular body for emitting ultrasound energy at a treatment site. A drug solution may also be delivered through the delivery lumen and out an exit port to the treatment site.

摘要翻译： 公开了适于接近远端解剖结构中的小血管的超声导管。 超声导管包括形成有输送腔的细长管状体。 管状体的灵活性和尺寸允许通过导丝进入远端解剖结构。 沿管状体的远端部设置有超声波辐射构件，用于在治疗部位发射超声能量。 药物溶液也可以通过输送腔输送出出口到治疗部位。