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1.发明授权Protein having fructosyl valyl histidine oxidase activity, modified protein, and use of the protein or the modified protein 有权具有果糖基缬氨酰基组氨酸氧化酶活性的蛋白质，修饰蛋白质，以及蛋白质或修饰蛋白质的使用公开(公告)号：US08993255B2
公开(公告)日：2015-03-31
申请号：US13123052
申请日：2009-10-06
申请人： Rie Hirao , Masao Kitabayashi , Yoshiaki Nishiya , Hiroki Ishida , Yoji Hata
发明人： Rie Hirao , Masao Kitabayashi , Yoshiaki Nishiya , Hiroki Ishida , Yoji Hata
CPC分类号： G01N33/723 , C12N9/0022 , C12Q1/26
摘要： The present invention provides: a protein having a fructosyl amino acid oxidase activity which protein is useful for measurement of a glycosylated protein (particularly, glycosylated hemoglobin); a modified protein thereof; and use of the protein or the modified protein. The protein of the present invention is, for example, a fructosyl valyl histidine oxidase derived from Phaeosphaeria nodorum, the fructosyl valyl histidine oxidase having excellent thermal stability and substrate specificity and also having a small Km value to fructosyl valyl histidine. This allows a glycosylated protein measuring reagent to be stored in a long time and measurement accuracy of the glycosylated protein measuring reagent to be improved.
摘要翻译： 本发明提供：具有果糖基氨基酸氧化酶活性的蛋白质，该蛋白质可用于糖基化蛋白质（特别是糖基化血红蛋白）的测定。 其改性蛋白质; 并使用蛋白质或修饰的蛋白质。 本发明的蛋白质是例如来源于花粉球形的果糖基缬氨酰基组氨酸氧化酶，具有优异的热稳定性和底物特异性的果糖基缬氨酰基组氨酸氧化酶，并且对于果糖基缬氨酰基组氨酸也具有小的Km值。 这样可以长时间地存储糖基化蛋白质测定试剂，改善糖基化蛋白质测定试剂的测定精度。
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2.发明申请NOVEL PROTEIN HAVING FRUCTOSYL VALYL HISTIDINE OXIDASE ACTIVITY, MODIFIED PROTEIN, AND USE OF THE PROTEIN OR THE MODIFIED PROTEIN 有权具有纤维蛋白胆固醇氧化酶活性，改良蛋白质的蛋白质和蛋白质或改性蛋白质的使用公开(公告)号：US20110195444A1
公开(公告)日：2011-08-11
申请号：US13123052
申请日：2009-10-06
申请人： Rie Hirao , Masao Kitabayashi , Yoshiaki Nishiya , Hiroki Ishida , Yoji Hata
发明人： Rie Hirao , Masao Kitabayashi , Yoshiaki Nishiya , Hiroki Ishida , Yoji Hata
CPC分类号： G01N33/723 , C12N9/0022 , C12Q1/26
摘要： The present invention provides: a protein having a fructosyl amino acid oxidase activity which protein is useful for measurement of a glycosylated protein (particularly, glycosylated hemoglobin); a modified protein thereof; and use of the protein or the modified protein. The protein of the present invention is, for example, a fructosyl valyl histidine oxidase derived from Phaeosphaeria nodorum, the fructosyl valyl histidine oxidase having excellent thermal stability and substrate specificity and also having a small Km value to fructosyl valyl histidine. This allows a glycosylated protein measuring reagent to be stored in a long time and measurement accuracy of the glycosylated protein measuring reagent to be improved.
摘要翻译： 本发明提供：具有果糖基氨基酸氧化酶活性的蛋白质，该蛋白质可用于糖基化蛋白质（特别是糖基化血红蛋白）的测定。 其改性蛋白质; 并使用蛋白质或修饰的蛋白质。 本发明的蛋白质是例如来源于花粉球形的果糖基缬氨酰基组氨酸氧化酶，具有优异的热稳定性和底物特异性的果糖基缬氨酰基组氨酸氧化酶，并且对于果糖基缬氨酰基组氨酸也具有小的Km值。 这样可以长时间地存储糖基化蛋白质测定试剂，改善糖基化蛋白质测定试剂的测定精度。
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