CHEMICAL SYNTHESIS USING UP-CONVERTING PHOSPHOR TECHNOLOGY AND HIGH SPEED FLOW CYTOMETRY
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    发明申请
    CHEMICAL SYNTHESIS USING UP-CONVERTING PHOSPHOR TECHNOLOGY AND HIGH SPEED FLOW CYTOMETRY 审中-公开
    使用UP转换磷酸盐技术和高速流式细胞仪的化学合成

    公开(公告)号:US20130150265A1

    公开(公告)日:2013-06-13

    申请号:US13578177

    申请日:2011-02-09

    IPC分类号: C07H21/04 C07K1/04

    摘要: The invention offers the ability to rapidly synthesize multiple chemical compounds, particularly polymers of varying sequences, in parallel on the surfaces of carrier beads. Tinvention involves attaching up-converting phosphors (UCP's) to beads to create up-converting phosphor-loaded beads (UCP-loaded beads) with unique spectral characteristics. Using a dynamic sorting architecture each bead is cataloged based on its spectral characteristics, assigned a compound or polymer to be synthesized, and subjected to multiple rounds of sorting by a flow cytometer, wherein each round sorts the bead to an appropriate bin for a selected chemical reaction, such as the attachment of a monomeric subunit of the polymer sequence.

    摘要翻译: 本发明提供了在载体珠粒表面上平行地快速合成多种化合物,特别是不同序列的聚合物的能力。 Tinvention包括将上变换荧光体(UCP)附着到珠上以产生具有独特光谱特征的上转换磷光体负载珠(UCP负载珠)。 使用动态分选结构,每个珠粒基于其光谱特征进行编目,分配待合成的化合物或聚合物,并通过流式细胞仪进行多轮分选,其中每个轮将珠粒分选为用于所选化学品的合适的容器 反应,例如聚合物序列的单体亚单位的连接。