公开(公告)号：US20130150265A1

公开(公告)日：2013-06-13

申请号：US13578177

申请日：2011-02-09

申请人： Robert Balog ,  David E. Cooper ,  Steven Crouch-Baker ,  Alexander J. Hallock ,  Georgina Hum ,  Maheen Samad ,  Angel Sanjurjo

发明人： Robert Balog ,  David E. Cooper ,  Steven Crouch-Baker ,  Alexander J. Hallock ,  Georgina Hum ,  Maheen Samad ,  Angel Sanjurjo

IPC分类号： C07H21/04 ,  C07K1/04

CPC分类号： C07H21/04 ,  C07K1/047 ,  G01N15/1459 ,  G01N2015/1488

摘要： The invention offers the ability to rapidly synthesize multiple chemical compounds, particularly polymers of varying sequences, in parallel on the surfaces of carrier beads. Tinvention involves attaching up-converting phosphors (UCP's) to beads to create up-converting phosphor-loaded beads (UCP-loaded beads) with unique spectral characteristics. Using a dynamic sorting architecture each bead is cataloged based on its spectral characteristics, assigned a compound or polymer to be synthesized, and subjected to multiple rounds of sorting by a flow cytometer, wherein each round sorts the bead to an appropriate bin for a selected chemical reaction, such as the attachment of a monomeric subunit of the polymer sequence.

摘要翻译： 本发明提供了在载体珠粒表面上平行地快速合成多种化合物，特别是不同序列的聚合物的能力。 Tinvention包括将上变换荧光体（UCP）附着到珠上以产生具有独特光谱特征的上转换磷光体负载珠（UCP负载珠）。 使用动态分选结构，每个珠粒基于其光谱特征进行编目，分配待合成的化合物或聚合物，并通过流式细胞仪进行多轮分选，其中每个轮将珠粒分选为用于所选化学品的合适的容器 反应，例如聚合物序列的单体亚单位的连接。

公开(公告)号：US06490011B1

公开(公告)日：2002-12-03

申请号：US09216408

申请日：1998-12-18

申请人： David E. Cooper ,  Kevin M. Egle ,  Warren J. Hartmann ,  Francis B. Huck, Jr.

发明人： David E. Cooper ,  Kevin M. Egle ,  Warren J. Hartmann ,  Francis B. Huck, Jr.

IPC分类号： H04N564

CPC分类号： G09F9/00

摘要： A display device convertible between a cave configuration and a wall configuration. The present display device includes a first display module having a display screen including first and second opposite peripheral edges and a first video projector for displaying an image on the display screen. The display device includes a second display module having a display screen including a peripheral edge and a second video projector for displaying an image on the display screen, and a third display module having a display screen including a peripheral edge and a third video projector for displaying an image on the display screen, wherein the second and third display modules are positionable with the respective peripheral edges of the display screens thereof in abutting relation to the display screen of the first display module with all of the display screens generally coplanar in the wall configuration, and wherein the second and third display modules are positionable with the respective peripheral edges of the display screens thereof in abutting relation to the display screen of the first display module and the display screens of the second and third display modules angularly related to the display screen of the first display module in the cave configuration.

摘要翻译： 可在洞穴配置和墙壁配置之间转换的显示设备。 本显示装置包括具有包括第一和第二相对外围边缘的显示屏的第一显示模块和用于在显示屏上显示图像的第一视频投影仪。 显示装置包括：第二显示模块，具有包括外围边缘的显示屏幕和用于在显示屏幕上显示图像的第二视频投影仪;以及第三显示模块，具有包括外围边缘的显示屏幕和用于显示的第三视频投影仪 显示屏上的图像，其中第二和第三显示模块可与其显示屏的相应外围边缘定位成与第一显示模块的显示屏幕邻接，其中所有显示屏幕在壁配置中大致共面 并且其中所述第二和第三显示模块可与其显示屏的相应外围边缘定位成与第一显示模块的显示屏幕相邻的关系以及与显示屏幕成角度相关的第二和第三显示模块的显示屏幕 的第一个显示模块在洞穴配置中。

公开(公告)号：US06312914B1

公开(公告)日：2001-11-06

申请号：US09690828

申请日：2000-10-18

申请人： Keith W. Kardos ,  R. Sam Niedbala ,  Jarrett Lee Burton ,  David E. Cooper ,  David A. Zarling ,  Michel J. Rossi ,  Norman A. Peppers ,  James Kane ,  Gregory W. Faris ,  Mark J. Dyer ,  Steve Y. Ng ,  Luke V. Schneider

发明人： Keith W. Kardos ,  R. Sam Niedbala ,  Jarrett Lee Burton ,  David E. Cooper ,  David A. Zarling ,  Michel J. Rossi ,  Norman A. Peppers ,  James Kane ,  Gregory W. Faris ,  Mark J. Dyer ,  Steve Y. Ng ,  Luke V. Schneider

IPC分类号： C12Q168

CPC分类号： G01N21/6452 ,  B01J2219/00315 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00707 ,  B82Y15/00 ,  C12Q1/6816 ,  C12Q1/6818 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6454 ,  G01N33/533 ,  G01N33/542 ,  G01N33/582 ,  G01N33/588 ,  G01N2015/149 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  C12Q2563/00 ,  C12Q2563/107 ,  C12Q2537/143

摘要： The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.

摘要翻译： 本发明提供了通过用上转换标记标记探针分子来进行分析物例如生物大分子和其它分析物的敏感检测的方法，组合物和装置。 上变换标签吸收来自照明源的辐射并以一个或多个更高频率发射辐射，提供增强的信噪比和基本消除背景样品自发荧光。 方法，组合物和装置适用于多种分析物的敏感检测和各种临床和环境取样技术。

公开(公告)号：US5572031A

公开(公告)日：1996-11-05

申请号：US344765

申请日：1994-11-23

申请人： David E. Cooper ,  Jan E. ver der Laan ,  Haris Riris ,  Clinton B. Carlisle

发明人： David E. Cooper ,  Jan E. ver der Laan ,  Haris Riris ,  Clinton B. Carlisle

IPC分类号： G01D3/036 ,  G01J3/28 ,  G01J3/433 ,  G01N21/39 ,  G01D21/02 ,  G01N21/00

CPC分类号： G01D3/0365 ,  G01J3/4338 ,  G01N21/39 ,  G01J2003/2866

摘要： RF modulation spectroscopy of a near-infrared tunable laser diode source is used to determine the oxygen concentration in a sample medium. A reference cell containing a known concentration of oxygen is used to calibrate the apparatus as well as to lock the laser on an oxygen absorption line. The temperature of the reference cell is monitored from which the pressure in the reference cell can be determined. Both the temperature and the pressure in the sample cell are monitored, either directly using independent transducers or indirectly using spectroscopic techniques. The oxygen content of the sample is determined, correcting for both temperature and pressure effects.

摘要翻译： 使用近红外可调激光二极管源的RF调制光谱来确定样品介质中的氧浓度。 使用含有已知浓度的氧的参比细胞来校准装置以及将激光器锁定在氧吸收线上。 监测参考电池的温度，从中可以确定参考电池中的压力。 监测样品池中的温度和压力，直接使用独立的换能器或间接使用光谱技术。 确定样品的氧含量，校正温度和压力的影响。

公开(公告)号：US5469143A

公开(公告)日：1995-11-21

申请号：US370637

申请日：1995-01-10

申请人： David E. Cooper

发明人： David E. Cooper

IPC分类号： G08B21/06 ,  G08B21/00

CPC分类号： G08B21/06

摘要： A sleep awakening device awakens drivers of motor vehicles who are falling asleep while driving. The sleep awakening device includes a pair of eyeglasses and a control unit electrically connected thereto to provide both visual and audible warnings to alert a driver who is falling asleep. The pair of eyeglasses include a sensing lever that is in constant contact with one of the driver's upper eyelid muscles. Downward motion of the eyelid moves the sensing lever downward and actuates a microswitch that is coupled to the sensing lever. The microswitch in turn actuates circuitry located in the control unit to turn on a light each time the driver closes his eyelid. The circuitry includes a time delay relay that initiates an audible signal if the eyelid remains closed for a preset period of time. A normal blink of a driver's eye does not produce an audible alarm. However, if the driver's eyelid fails to open in a predetermined time, the audible alarm will sound. As soon as the driver's eyelid opens, a yellow caution light and the audible alarm are reset. Normal eye blinks produce illumination of the yellow caution light in view of the driver, thereby assuring the driver that the sleep awakening device is functioning properly.

摘要翻译： 睡眠觉醒装置唤醒驾驶时入睡的汽车司机。 睡眠觉醒装置包括一对眼镜和与其连接的控制单元，以提供视觉和听觉警告以警告正在入睡的驾驶员。 一对眼镜包括与驾驶员的上眼睑肌肉不断接触的传感杆。 眼皮的向下运动将感测杆向下移动并致动耦合到感测杆的微动开关。 微动开关又驱动位于控制单元中的电路，以在每次驾驶员关闭眼睑时打开灯。 该电路包括一个延时继电器，如果眼睑保持关闭一段预设的时间，该延时继电器启动一个可听见的信号。 驾驶员的正常眨眼不会产生声音报警。 但是，如果驾驶员的眼睑在预定时间内未能打开，则会发出声音报警。 一旦驾驶员的眼睑打开，一个黄色的警告灯和声音报警器被复位。 鉴于驾驶员，正常的眼睛闪烁会产生黄色警告灯的照明，从而确保驾驶员睡眠觉醒装置正常工作。

公开(公告)号：US5317156A

公开(公告)日：1994-05-31

申请号：US827209

申请日：1992-01-29

申请人： David E. Cooper ,  Clinton B. Carlisle ,  Haris Riris

发明人： David E. Cooper ,  Clinton B. Carlisle ,  Haris Riris

IPC分类号： G01N21/35 ,  G01N21/39

CPC分类号： G01N21/39 ,  G01N2021/399 ,  G01N21/031 ,  G01N21/359

摘要： RF modulation spectroscopy of a near infrared laser diode source is used to determine the amount of a target substance in a breath sample. In this type of modulation the laser output is modulated to produce sidebands displaced from the laser carrier by the modulation frequency. The modulated beam is passed through a gas sample which differentially absorbs the sidebands, the result of which is the conversion of some of the laser frequency modulation into amplitude modulation which is subsequently detected using a broadband photodetector. In certain tests, the target substance is a particular isotope, whose concentration is measured as an isotope ratio. In order to measure the presence of first and second isotopic species, provision is made to provide laser illumination at characteristic wavelengths for absorption lines for the first and second isotopic species of the gas. This may sometimes be accomplished using a single laser diode and scanning at least one of its operating parameters in order to achieve one of the wavelength difference. Alternatively, first and second laser diodes operating at the first and second wavelengths are used.

摘要翻译： 使用近红外激光二极管源的RF调制光谱来确定呼吸样品中目标物质的量。 在这种类型的调制中，激光输出被调制以产生从激光载体偏移调制频率的边带。 调制光束通过差分吸收边带的气体样品，其结果是将一些激光频率调制转换成幅度调制，随后使用宽带光电探测器检测。 在某些测试中，目标物质是特定的同位素，其浓度以同位素比率测量。 为了测量第一和第二同位素物种的存在，提供了为特征波长提供用于气体的第一和第二同位素物种的吸收线的激光照明。 有时可以使用单个激光二极管实现这一点，并且扫描其操作参数中的至少一个，以便实现波长差之一。 或者，使用以第一和第二波长工作的第一和第二激光二极管。

公开(公告)号：US06664533B1

公开(公告)日：2003-12-16

申请号：US09488453

申请日：2000-01-20

申请人： Jan E. van der Laan ,  David E. Cooper ,  Russell E. Warren ,  Sylvie Carlisle

发明人： Jan E. van der Laan ,  David E. Cooper ,  Russell E. Warren ,  Sylvie Carlisle

IPC分类号： H01J4014

CPC分类号： G01N21/538 ,  G01J3/433 ,  G01N21/39 ,  G01N2021/1793

摘要： This specification discloses a method and apparatus for the mobile and remote detection of a gas, such as methane, in the atmosphere. The apparatus includes a TDL based Light Detection and Ranging (LIDAR) driven at carrier frequency lying within the absorption line of the gas. The apparatus also drives the TDL with a modulation frequency to generate upper and lower sidebands in the output of the TDL and with a low ramp frequency to sweep the output of the TDL across twice the width of the pressure-broadened absorption line of the gas, preferably the first overtone absorption line in the case of methane detection. The apparatus include reference and calibration cells or chambers, and includes a light collector and detectors to detect the quantity and modulation of the light that passes the reference or calibration cells and that is received by the apparatus after reflection back toward the apparatus from an uncooperative target. The apparatus further includes a signal processor that applies a derivative spectroscopy technique, such as frequency modulation spectroscopy or wavelength modulation spectroscopy, to determine the presence of the gas in the atmosphere.

摘要翻译： 本说明书公开了一种用于在大气中移动和远程检测诸如甲烷的气体的方法和装置。 该装置包括在位于气体的吸收线内的载波频率下驱动的基于TDL的光检测和测距（LIDAR）。 该装置还驱动具有调制频率的TDL，以在TDL的输出中产生上边带和下边带，并具有低斜坡频率，以扫过TDL的输出跨过气体的加压扩大吸收线的两倍宽度， 在甲烷检测的情况下，优选地是第一泛音吸收线。 该装置包括参考和校准单元或室，并且包括光收集器和检测器，用于检测通过参考或校准单元的光的数量和调制，并且在从不合作的目标反射回设备之后由设备接收 。 该装置还包括信号处理器，其应用衍生光谱技术，例如频率调制光谱或波长调制光谱，以确定气体在大气中的存在。

公开(公告)号：US06631019B1

公开(公告)日：2003-10-07

申请号：US09610312

申请日：2000-07-05

申请人： Pajo Vujkovic-Cvijin ,  David E. Cooper

发明人： Pajo Vujkovic-Cvijin ,  David E. Cooper

IPC分类号： H04B1004

CPC分类号： H04J14/02 ,  H01S3/1303 ,  H01S5/026 ,  H01S5/06825 ,  H01S5/4025 ,  H04B10/506 ,  H04B10/572

摘要： A high performance reconfigurable DWDM transmitter incorporates discrete optical components placed in v grooves etched in a substrate. Direct wavelength monitoring can be achieved with wavelength modulation locking applied independently to a gas absorption line and to etalon fringes. A set of equally-spaced wavelengths may be provided by a set of lasers, or a single laser can be used for a number of fixed frequencies.

摘要翻译： 高性能可重新配置的DWDM发射器将分散的光学元件放置在蚀刻在衬底中的v沟槽中。 可以通过独立地应用于气体吸收线和标准具条纹的波长调制锁定来实现直接波长监测。 一组等间隔的波长可以由一组激光器提供，或者单个激光器可以用于多个固定频率。

公开(公告)号：US06621531B2

公开(公告)日：2003-09-16

申请号：US10262708

申请日：2002-10-02

申请人： David E. Cooper ,  Kevin M. Egle ,  Warren J. Hartmann ,  Francis B. Huck, Jr.

发明人： David E. Cooper ,  Kevin M. Egle ,  Warren J. Hartmann ,  Francis B. Huck, Jr.

IPC分类号： H04N564

CPC分类号： G09F9/00

摘要： A method for converting a wall configuration of a display device to a cave configuration, the display device including a first display module having a display screen including first and second opposite peripheral edges and means for displaying an image on the display screen, a second display module having a display screen including a peripheral edge and means for displaying an image on the display screen, and a third display model having a display screen including a peripheral edge and means for displaying an image on the display screen. Additionally the invention includes a method for converting a cave configuration of a display device to a wall configuration.

摘要翻译： 一种用于将显示装置的墙壁配置转换为洞穴配置的方法，所述显示装置包括具有包括第一和第二相对外围边缘的显示屏的第一显示模块和用于在所述显示屏上显示图像的装置，第二显示模块 具有包括外围边缘的显示屏幕和用于在显示屏幕上显示图像的装置，以及具有包括外围边缘的显示屏幕的第三显示模型和用于在显示屏幕上显示图像的装置。 另外本发明还包括一种用于将显示装置的洞穴配置转换成墙壁配置的方法。

公开(公告)号：US06504225B1

公开(公告)日：2003-01-07

申请号：US09837358

申请日：2001-04-18

申请人： Michael McCarthy ,  David E. Cooper ,  Denise C. Sale

发明人： Michael McCarthy ,  David E. Cooper ,  Denise C. Sale

IPC分类号： H01L2900

CPC分类号： H01L22/34

摘要： Various embodiments of a circuit device for detecting the presence of unwanted conductor structures in insulation structure seams and methods of making the same are provided. In one aspect, a circuit device is provided that includes an insulating structure positioned on a substrate and a first conductor structure that has a first member positioned on the insulating structure. A second conductor structure is provided that has a second member positioned on the insulating structure. The second member projects toward the first conductor structure and the first member projects toward the second conductor structure, but the first and second conductor structures are not in physical contact. A current flowing between the first and second conductor structures when a bias is applied between the first and second conductor structures is indicative of a third conductor structure present on the insulating structure and contacting the first and second members.

摘要翻译： 提供了用于检测绝缘结构接缝中不需要的导体结构的存在的电路装置的各种实施例及其制造方法。 一方面，提供一种电路装置，其包括位于基板上的绝缘结构和具有位于绝缘结构上的第一构件的第一导体结构。 提供了第二导体结构，其具有位于绝缘结构上的第二构件。 第二个构件向第一导体结构突出，第一个构件向第二导体结构突出，但是第一和第二导体结构没有物理接触。 当在第一和第二导体结构之间施加偏压时，在第一和第二导体结构之间流动的电流表示存在于绝缘结构上并与第一和第二构件接触的第三导体结构。