公开(公告)号：US20050095676A1

公开(公告)日：2005-05-05

申请号：US10913944

申请日：2004-08-06

申请人： Nabil El Tayar ,  Robert Campbell ,  Christie Kelton ,  Chaomei He ,  Susan Kiernan

发明人： Nabil El Tayar ,  Robert Campbell ,  Christie Kelton ,  Chaomei He ,  Susan Kiernan

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/59 ,  C07K16/26 ,  A61K38/22 ,  C07H21/04 ,  C07K14/565

CPC分类号： C07K14/575 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/59 ,  C07K16/26 ,  C07K2317/34

摘要： The present invention provides novel isolated ARP/BRP polynucleotides and the membrane-associated or secreted polypeptides encoded by the ARP/BRP polynucleotides. Also provided are ARP and BRP protein multimers. Further provided are the antibodies that immunospecifically bind to a ARP/BRP polypeptide or any derivative, variant, mutant or fragment of the ARP/BRP polypeptide, a ARP/BRP multimer polynucleotide or antibody. The invention additionally provides methods in which the ARP/BRP polypeptide, multimer, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, e.g. reproductive disorder, as well as to other uses.

摘要翻译： 本发明提供新的分离的ARP / BRP多核苷酸和由ARP / BRP多核苷酸编码的膜相关或分泌的多肽。 还提供了ARP和BRP蛋白多聚体。 还提供免疫特异性结合ARP / BRP多肽或ARP / BRP多肽的任何衍生物，变体，突变体或片段，ARP / BRP多聚体多核苷酸或抗体的抗体。 本发明还提供了其中使用ARP / BRP多肽，多聚体，多核苷酸和抗体来检测和治疗广泛的病理状态的方法，例如， 生殖障碍，以及其他用途。

公开(公告)号：US20050069914A1

公开(公告)日：2005-03-31

申请号：US10811081

申请日：2004-03-25

申请人： Robert Campbell ,  Christie Kelton ,  Chaomei He ,  Susan Kiernan ,  Nabil El Tayar

发明人： Robert Campbell ,  Christie Kelton ,  Chaomei He ,  Susan Kiernan ,  Nabil El Tayar

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/59 ,  C07K16/26 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C07K14/575 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/59 ,  C07K16/26 ,  C07K2317/34

摘要： The present invention provides novel isolated ARP/BRP polynucleotides and the membrane-associated or secreted polypeptides encoded by the ARP/BRP polynucleotides. Also provided are ARP and BRP protein multimers. Further provided are the antibodies that immunospecifically bind to a ARP/BRP polypeptide or any derivative, variant, mutant or fragment of the ARP/BRP polypeptide, a ARP/BRP multimer polynucleotide or antibody. The invention additionally provides methods in which the ARP/BRP polypeptide, multimer, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, e.g. reproductive disorder, as well as to other uses.