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公开(公告)号：US20090298175A1
公开(公告)日：2009-12-03
申请号：US12404943
申请日：2009-03-16
CPC分类号： C12N15/85 , A61K31/575 , C07C49/727 , C07C49/753 , C07J9/00 , C07K14/70567 , C07K2319/715 , C12N2830/002
摘要： The present invention relates to steroidal ligands for use in nuclear receptor-based inducible gene expression systems. The invention further relates to methods of modulating the expression of genes of interest with a system containing one or more nuclear receptor complexes and one or more steroidal ligands. Further aspects include ligand compositions including therapeutic compositions.
摘要翻译： 本发明涉及用于基于核受体的诱导型基因表达系统的甾体配体。 本发明还涉及用含有一种或多种核受体复合物和一种或多种甾体配体的系统调节感兴趣的基因表达的方法。 其它方面包括包括治疗组合物的配体组合物。
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公开(公告)号：US08536354B2
公开(公告)日：2013-09-17
申请号：US12404943
申请日：2009-03-16
IPC分类号： A61K31/575 , C07J9/00
CPC分类号： C12N15/85 , A61K31/575 , C07C49/727 , C07C49/753 , C07J9/00 , C07K14/70567 , C07K2319/715 , C12N2830/002
摘要： The present invention relates to steroidal ligands for use in nuclear receptor-based inducible gene expression systems. The invention further relates to methods of modulating the expression of genes of interest with a system containing one or more nuclear receptor complexes and one or more steroidal ligands. Further aspects include ligand compositions including therapeutic compositions.
摘要翻译： 本发明涉及用于基于核受体的诱导型基因表达系统的甾体配体。 本发明还涉及用含有一种或多种核受体复合物和一种或多种甾体配体的系统调节感兴趣的基因表达的方法。 其它方面包括包括治疗组合物的配体组合物。
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